{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994902674432.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/s0014-5793(01)02236-0"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793%2801%2902236-0"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793(01)02236-0"}},{"identifier":{"@type":"URI","@value":"https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/S0014-5793%2801%2902236-0"}}],"dc:title":[{"@value":"The TIM‐barrel fold: a versatile framework for efficient enzymes"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Recent studies on triosephosphate isomerase (TIM)‐barrel enzymes highlight the remarkable versatility of the TIM‐barrel scaffold. At least 15 distinct enzyme families use this framework to generate the appropriate active site geometry, always at the C‐terminal end of the eight parallel β‐strands of the barrel. Sequence and structure comparisons now suggest that many of the TIM‐barrel enzymes are evolutionarily related. Common structural properties of TIM‐barrel enzymes are discussed.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380021390765477384","@type":"Researcher","foaf:name":[{"@value":"R.K Wierenga"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00145793"},{"@type":"EISSN","@value":"18733468"}],"prism:publicationName":[{"@value":"FEBS Letters"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2001-03-12","prism:volume":"492","prism:number":"3","prism:startingPage":"193","prism:endingPage":"198"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793%2801%2902236-0"},{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793(01)02236-0"},{"@id":"https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/S0014-5793%2801%2902236-0"}],"createdAt":"2002-07-25","modifiedAt":"2023-09-16","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050299693926748160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Molecular Dynamics Simulations Accelerated by GPU for Biological Macromolecules with a Non-Ewald Scheme for Electrostatic Interactions"},{"@value":"Exhaustive comparison and classification of ligand‐binding surfaces in proteins"},{"@value":"Exhaustive comparison and classification of ligand-binding surfaces in proteins"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021390765477504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Primitive purine biosynthesis connects ancient geochemistry to modern metabolism"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567184574729088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Characterization of the mutant β-subunit of β-hexosaminidase for dimer formation responsible for the adult form of Sandhoff disease with the motor neuron disease phenotype"}]},{"@id":"https://cir.nii.ac.jp/crid/1361976069305186176","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Olefin metathesis catalysts embedded in β-barrel proteins: creating artificial metalloproteins for olefin metathesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205104692736","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Validation of Techniques for Structure Prediction and Thermostabilization of a Protein"},{"@language":"ja","@value":"蛋白質の構造予測と安定化のための技術の検証"}]},{"@id":"https://cir.nii.ac.jp/crid/1520573329915210496","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cloning, expression, and characterization of novel GH5 endoglucanases from Thermobifida alba AHK119"}]},{"@id":"https://cir.nii.ac.jp/crid/1521699230257070976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Daidzein reductase of Eggerthella sp. 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