{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994956985216.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1136/oemed-2017-104651"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1136/oemed-2017-104651"}}],"dc:title":[{"@value":"Half-lives of PFOS, PFHxS and PFOA after end of exposure to contaminated drinking water"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec><jats:title>Background</jats:title><jats:p>Municipal drinking water contaminated with perfluorinated alkyl acids had been distributed to one-third of households in Ronneby, Sweden. The source was firefighting foam used in a nearby airfield since the mid-1980s. Clean water was provided from 16 December 2013.</jats:p></jats:sec><jats:sec><jats:title>Objective</jats:title><jats:p>To determine the rates of decline in serum perfluorohexane sulfonate (PFHxS), perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA), and their corresponding half-lives.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Up to seven blood samples were collected between June 2014 and September 2016 from 106 participants (age 4–84 years, 53% female).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Median initial serum concentrations were PFHxS, 277 ng/mL (range 12–1660); PFOS, 345 ng/mL (range 24–1500); and PFOA, 18 ng/mL (range 2.4–92). The covariate-adjusted average rates of decrease in serum were PFHxS, 13% per year (95% CI 12% to 15%); PFOS, 20% per year (95% CI 19% to 22%); and PFOA, 26% per year (95% CI 24% to 28%). The observed data are consistent with a first-order elimination model. The mean estimated half-life was 5.3 years (95% CI 4.6 to 6.0) for PFHxS, 3.4 years (95% CI 3.1 to 3.7) for PFOS and 2.7 years (95% CI 2.5 to 2.9) for PFOA. The interindividual variation of half-life was around threefold when comparing the 5th and 95th percentiles. There was a marked sex difference with more rapid elimination in women for PFHxS and PFOS, but only marginally for PFOA.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The estimated half-life for PFHxS was considerably longer than for PFOS and PFOA. For PFHxS and PFOS, the average half-life is shorter than the previously published estimates. For PFOA the half-life is in line with the range of published estimates.</jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699994956985217","@type":"Researcher","foaf:name":[{"@value":"Ying Li"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994956985221","@type":"Researcher","foaf:name":[{"@value":"Tony Fletcher"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994956985344","@type":"Researcher","foaf:name":[{"@value":"Daniel Mucs"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994956985216","@type":"Researcher","foaf:name":[{"@value":"Kristin Scott"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994956985218","@type":"Researcher","foaf:name":[{"@value":"Christian H Lindh"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994956985219","@type":"Researcher","foaf:name":[{"@value":"Pia Tallving"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994956985220","@type":"Researcher","foaf:name":[{"@value":"Kristina Jakobsson"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13510711"},{"@type":"EISSN","@value":"14707926"}],"prism:publicationName":[{"@value":"Occupational and Environmental Medicine"}],"dc:publisher":[{"@value":"BMJ"}],"prism:publicationDate":"2017-11-13","prism:volume":"75","prism:number":"1","prism:startingPage":"46","prism:endingPage":"51"},"reviewed":"false","url":[{"@id":"https://syndication.highwire.org/content/doi/10.1136/oemed-2017-104651"}],"createdAt":"2017-11-13","modifiedAt":"2020-09-26","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360017280667579776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Sorption of Per- and Polyfluoroalkyl Substances (PFAS) using Polyethylene (PE) microplastics as adsorbent: Grand Canonical Monte Carlo and Molecular Dynamics (GCMC-MD) 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