{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699994988635904.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/hep.22106"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhep.22106"}},{"identifier":{"@type":"URI","@value":"https://journals.lww.com/01515467-200803000-00011"}}],"dc:title":[{"@value":"A revisit of prophylactic lamivudine for chemotherapy-associated hepatitis B reactivation in non-Hodgkin's lymphoma: A randomized trial"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec>\n            <jats:title/>\n            <jats:p>\n                                 <jats:bold>Lamivudine is effective to control hepatitis B virus (HBV) reactivation in HBV-carrying cancer patients who undergo chemotherapy, but the optimal treatment protocol remains undetermined. In this study, HBV carriers with newly diagnosed non-Hodgkin's lymphoma (NHL) who underwent chemotherapy were randomized to either prophylactic (P) or therapeutic (T) lamivudine treatment groups. Group P patients started lamivudine from day 1 of the first course of chemotherapy and continued treatment until 2 months after completion of chemotherapy. Group T patients received chemotherapy alone and started lamivudine treatment only if serum alanine aminotransferase (ALT) levels elevated to greater than 1.5-fold of the upper normal limit (ULN). The primary endpoint was incidence of HBV reactivation during the 12 months after starting chemotherapy. During chemotherapy, fewer group P patients had HBV reactivation (11.5% versus 56%,</jats:bold>\n                                 <jats:bold>\n                                    P\n                                 </jats:bold>\n                                 <jats:bold>= 0.001), HBV-related hepatitis (7.7% versus 48%,</jats:bold>\n                                 <jats:bold>\n                                    P\n                                 </jats:bold>\n                                 <jats:bold>= 0.001), or severe hepatitis (ALT more than 10-fold ULN) (0 versus 36%,</jats:bold>\n                                 <jats:bold>\n                                    P\n                                 </jats:bold>\n                                 <jats:bold>< 0.001). No hepatitis-related deaths occurred during protocol treatment. Prophylactic lamivudine use was the only independent predictor of HBV reactivation. After completion of chemotherapy, the incidence of HBV reactivation did not differ between the 2 groups. Two patients, both in group P, died of HBV reactivation–related hepatitis, 173 and 182 days, respectively, after completion of protocol treatment. When compared with an equivalent group of lamivudine-naïve lymphoma patients who underwent chemotherapy, therapeutic use of lamivudine neither reduced the severity of HBV-related hepatitis nor changed the patterns of HBV reactivation.</jats:bold>\n                                 <jats:bold>\n                                    Conclusion:\n                                 </jats:bold>\n                                 <jats:bold>Prophylactic lamivudine use, but not therapeutic use, reduces the incidence and severity of chemotherapy-related HBV reactivation in NHL patients.</jats:bold>\n                              </jats:p>\n          </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699994988635917","@type":"Researcher","foaf:name":[{"@value":"Chiun Hsu"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994988635908","@type":"Researcher","foaf:name":[{"@value":"Chao A. Hsiung"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994988635776","@type":"Researcher","foaf:name":[{"@value":"Ih-Jen Su"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994988635911","@type":"Researcher","foaf:name":[{"@value":"Wei-Shou Hwang"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994988635777","@type":"Researcher","foaf:name":[{"@value":"Ming-Chung Wang"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994988635905","@type":"Researcher","foaf:name":[{"@value":"Sheng-Fung Lin"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994988635910","@type":"Researcher","foaf:name":[{"@value":"Tseng-Hsi Lin"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994988635916","@type":"Researcher","foaf:name":[{"@value":"Hui-Hua Hsiao"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994988635904","@type":"Researcher","foaf:name":[{"@value":"Ji-Hsiung Young"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994988635909","@type":"Researcher","foaf:name":[{"@value":"Ming-Chih Chang"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994988635906","@type":"Researcher","foaf:name":[{"@value":"Yu-Min Liao"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994988635919","@type":"Researcher","foaf:name":[{"@value":"Chi-Cheng Li"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994988635907","@type":"Researcher","foaf:name":[{"@value":"Hung-Bo Wu"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994988635912","@type":"Researcher","foaf:name":[{"@value":"Hwei-Fang Tien"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994988635913","@type":"Researcher","foaf:name":[{"@value":"Tsu-Yi Chao"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994988635914","@type":"Researcher","foaf:name":[{"@value":"Tsang-Wu Liu"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994988635915","@type":"Researcher","foaf:name":[{"@value":"Ann-Lii Cheng"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699994988635918","@type":"Researcher","foaf:name":[{"@value":"Pei-Jer Chen"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"02709139"}],"prism:publicationName":[{"@value":"Hepatology"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2008-03","prism:volume":"47","prism:number":"3","prism:startingPage":"844","prism:endingPage":"853"},"reviewed":"false","dc:rights":["http://doi.wiley.com/10.1002/tdm_license_1.1"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhep.22106"},{"@id":"https://journals.lww.com/01515467-200803000-00011"}],"createdAt":"2008-02-07","modifiedAt":"2024-12-01","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002218323019648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Prevention of hepatitis B virus reactivation in patients receiving immunosuppressive therapy or chemotherapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142633480320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Prophylactic antiviral therapy for hepatitis B virus surface antigen‐positive patients with diffuse large B‐cell lymphoma treated with rituximab‐containing chemotherapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285711733152384","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Screening for and management of hepatitis B virus reactivation in patients treated with anti-B-cell therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168116348928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"JSH Guidelines for the Management of Hepatitis B Virus Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861705572330752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Prophylactic tenofovir alafenamide for hepatitis B virus reactivation and reactivation‐related hepatitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679771619840","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Two cases of acute hepatitis due to hepatitis E virus that are indigenous to Kitakyushu: a case report"},{"@language":"ja","@value":"北九州に土着したE型肝炎ウイルス株による急性肝炎の2例"},{"@value":"B型肝炎治療ガイドライン(第1.1版)"},{"@language":"ja-Kana","@value":"Bガタ カンエン チリョウ ガイドライン(ダイ1.1ハン)"},{"@language":"ja-Kana","@value":"キタキュウシュウ ニ ドチャク シタ Eガタ カンエンウイルスカブ ニ ヨル キュウセイ カンエン ノ 2レイ"},{"@value":"Guidelines for the management of hepatitis B virus 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