{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699995048007680.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1073/pnas.95.25.14869"}},{"identifier":{"@type":"URI","@value":"https://pnas.org/doi/pdf/10.1073/pnas.95.25.14869"}},{"identifier":{"@type":"NAID","@value":"80010874532"}}],"dc:title":[{"@value":"Genome scan of human systemic lupus erythematosus: Evidence for linkage on chromosome 1q in African-American pedigrees"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n            Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by production of autoantibodies against intracellular antigens including DNA, ribosomal P, Ro (SS-A), La (SS-B), and the spliceosome. Etiology is suspected to involve genetic and environmental factors. Evidence of genetic involvement includes: associations with HLA-DR3, HLA-DR2, Fcγ receptors (FcγR) IIA and IIIA, and hereditary complement component deficiencies, as well as familial aggregation, monozygotic twin concordance >20%, λ\n            <jats:sub>s</jats:sub>\n            > 10, purported linkage at 1q41–42, and inbred mouse strains that consistently develop lupus. We have completed a genome scan in 94 extended multiplex pedigrees by using model-based linkage analysis. Potential [log\n            <jats:sub>10</jats:sub>\n            of the odds for linkage (lod) > 2.0] SLE loci have been identified at chromosomes 1q41, 1q23, and 11q14–23 in African-Americans; 14q11, 4p15, 11q25, 2q32, 19q13, 6q26–27, and 12p12–11 in European-Americans; and 1q23, 13q32, 20q13, and 1q31 in all pedigrees combined. An effect for the FcγRIIA candidate polymorphism) at 1q23 (lod = 3.37 in African-Americans) is syntenic with linkage in a murine model of lupus. Sib-pair and multipoint nonparametric analyses also support linkage (\n            <jats:italic>P</jats:italic>\n            < 0.05) at nine loci detected by using two-point lod score analysis (lod > 2.0). Our results are consistent with the presumed complexity of genetic susceptibility to SLE and illustrate racial origin is likely to influence the specific nature of these genetic effects.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380857613168380290","@type":"Researcher","foaf:name":[{"@value":"Kathy L. Moser"}],"jpcoar:affiliationName":[{"@value":"Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613168380302","@type":"Researcher","foaf:name":[{"@value":"Barbara R. Neas"}],"jpcoar:affiliationName":[{"@value":"Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613168380309","@type":"Researcher","foaf:name":[{"@value":"Jane E. Salmon"}],"jpcoar:affiliationName":[{"@value":"Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613168380304","@type":"Researcher","foaf:name":[{"@value":"Hua Yu"}],"jpcoar:affiliationName":[{"@value":"Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613168380288","@type":"Researcher","foaf:name":[{"@value":"Courtney Gray-McGuire"}],"jpcoar:affiliationName":[{"@value":"Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613168380303","@type":"Researcher","foaf:name":[{"@value":"Neeraj Asundi"}],"jpcoar:affiliationName":[{"@value":"Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613168380308","@type":"Researcher","foaf:name":[{"@value":"Gail R. Bruner"}],"jpcoar:affiliationName":[{"@value":"Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613168380293","@type":"Researcher","foaf:name":[{"@value":"Jerome Fox"}],"jpcoar:affiliationName":[{"@value":"Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613168380294","@type":"Researcher","foaf:name":[{"@value":"Jennifer Kelly"}],"jpcoar:affiliationName":[{"@value":"Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613168380291","@type":"Researcher","foaf:name":[{"@value":"Stephanie Henshall"}],"jpcoar:affiliationName":[{"@value":"Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613168380289","@type":"Researcher","foaf:name":[{"@value":"Debra Bacino"}],"jpcoar:affiliationName":[{"@value":"Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613168380310","@type":"Researcher","foaf:name":[{"@value":"Myron Dietz"}],"jpcoar:affiliationName":[{"@value":"Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613168380300","@type":"Researcher","foaf:name":[{"@value":"Robert Hogue"}],"jpcoar:affiliationName":[{"@value":"Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613168380305","@type":"Researcher","foaf:name":[{"@value":"Gerald Koelsch"}],"jpcoar:affiliationName":[{"@value":"Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613168380307","@type":"Researcher","foaf:name":[{"@value":"Lydia Nightingale"}],"jpcoar:affiliationName":[{"@value":"Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613168380301","@type":"Researcher","foaf:name":[{"@value":"Tim Shaver"}],"jpcoar:affiliationName":[{"@value":"Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613168380297","@type":"Researcher","foaf:name":[{"@value":"Nabih I. Abdou"}],"jpcoar:affiliationName":[{"@value":"Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613168380292","@type":"Researcher","foaf:name":[{"@value":"Daniel A. Albert"}],"jpcoar:affiliationName":[{"@value":"Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613168380296","@type":"Researcher","foaf:name":[{"@value":"Craig Carson"}],"jpcoar:affiliationName":[{"@value":"Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613168380299","@type":"Researcher","foaf:name":[{"@value":"Michelle Petri"}],"jpcoar:affiliationName":[{"@value":"Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613168380295","@type":"Researcher","foaf:name":[{"@value":"Edward L. Treadwell"}],"jpcoar:affiliationName":[{"@value":"Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613168380306","@type":"Researcher","foaf:name":[{"@value":"Judith A. James"}],"jpcoar:affiliationName":[{"@value":"Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380857613168380298","@type":"Researcher","foaf:name":[{"@value":"John B. Harley"}],"jpcoar:affiliationName":[{"@value":"Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,..."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00278424"},{"@type":"EISSN","@value":"10916490"}],"prism:publicationName":[{"@value":"Proceedings of the National Academy of Sciences"}],"dc:publisher":[{"@value":"Proceedings of the National Academy of Sciences"}],"prism:publicationDate":"1998-12-08","prism:volume":"95","prism:number":"25","prism:startingPage":"14869","prism:endingPage":"14874"},"reviewed":"false","url":[{"@id":"https://pnas.org/doi/pdf/10.1073/pnas.95.25.14869"}],"createdAt":"2002-07-26","modifiedAt":"2022-04-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285706278737152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A trans-ethnic genetic study of rheumatoid arthritis identified FCGR2A as a candidate common risk factor in Japanese and European populations"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168404888704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Identification of Therapeutic Targets for Quiescent, Chemotherapy-Resistant Human Leukemia Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206442565248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Forefront of medical science and medical care.  Genetic analysis of collagen disease."},{"@value":"医学と医療の最前線　　こう原病の遺伝子解析"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206446264320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"6.膠原病の概念"},{"@language":"ja-Kana","@value":"コウゲンビョウ ノ ガイネン"},{"@language":"en","@value":"[Progress in the study of allergy and collagen disease in the last 100 years: Concept of collagen disease]."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679626734464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"ゲノム解析によるリウマチ性疾患の病因・病態解明へのアプローチ"},{"@language":"en","@value":"[Elucidation of the etiology and pathophysiology of rheumatic diseases by genomic study]."}]},{"@id":"https://cir.nii.ac.jp/crid/1570009750174048640","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"日本人全身性エリテマトーデスにおけるFcγ受容体遺伝子群多型の関連"},{"@language":"en","@value":"Association of Fcγ receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261549229698048","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"全身性エリテマトーデス"},{"@language":"en","@value":"Systemic Lupus Erythematosus"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105975676112896","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"T-cell receptor ζmRNA with an alternatively spliced 3' untranslated region is generated predominantly in the peripheral blood T cells of systemic lupus erythematosus patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668924839281920","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Molecular genetic analyses of human NKG2C (KLRC2) gene deletion"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950400513695360","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A trans-ethnic genetic study of rheumatoid arthritis identified FCGR2A as a candidate common risk factor in Japanese and European populations"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1073/pnas.95.25.14869"},{"@type":"CIA","@value":"80010874532"},{"@type":"CROSSREF","@value":"10.1007/s10165-011-0467-y_references_DOI_776TT4i0hulA7ab1OaZ7B0xoI1E"},{"@type":"CROSSREF","@value":"10.1126/scitranslmed.3000349_references_DOI_776TT4i0hulA7ab1OaZ7B0xoI1E"}]}