{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699995062562816.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1261/rna.1528909"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1261/rna.1528909"}}],"dc:title":[{"@value":"Small RNAs derived from snoRNAs"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Small nucleolar RNAs (snoRNAs) guide RNA modification and are localized in nucleoli and Cajal bodies in eukaryotic cells. Components of the RNA silencing pathway associate with these structures, and two recent reports have revealed that a human and a protozoan snoRNA can be processed into miRNA-like RNAs. Here we show that small RNAs with evolutionary conservation of size and position are derived from the vast majority of snoRNA loci in animals (human, mouse, chicken, fruit fly), <jats:italic>Arabidopsis</jats:italic>, and fission yeast. In animals, sno-derived RNAs (sdRNAs) from H/ACA snoRNAs are predominantly 20–24 nucleotides (nt) in length and originate from the 3′ end. Those derived from C/D snoRNAs show a bimodal size distribution at ∼17–19 nt and >27 nt and predominantly originate from the 5′ end. SdRNAs are associated with AGO7 in <jats:italic>Arabidopsis</jats:italic> and Ago1 in fission yeast with characteristic 5′ nucleotide biases and show altered expression patterns in fly <jats:italic>loquacious</jats:italic> and <jats:italic>Dicer-2</jats:italic> and mouse <jats:italic>Dicer1</jats:italic> and <jats:italic>Dgcr8</jats:italic> mutants. These findings indicate that there is interplay between the RNA silencing and snoRNA-mediated RNA processing systems, and that sdRNAs comprise a novel and ancient class of small RNAs in eukaryotes.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699995062562821","@type":"Researcher","foaf:name":[{"@value":"Ryan J. Taft"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995062562816","@type":"Researcher","foaf:name":[{"@value":"Evgeny A. Glazov"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995062562818","@type":"Researcher","foaf:name":[{"@value":"Timo Lassmann"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995062562817","@type":"Researcher","foaf:name":[{"@value":"Yoshihide Hayashizaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995062562819","@type":"Researcher","foaf:name":[{"@value":"Piero Carninci"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995062562820","@type":"Researcher","foaf:name":[{"@value":"John S. Mattick"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13558382"},{"@type":"EISSN","@value":"14699001"}],"prism:publicationName":[{"@value":"RNA"}],"dc:publisher":[{"@value":"Cold Spring Harbor Laboratory"}],"prism:publicationDate":"2009-05-27","prism:volume":"15","prism:number":"7","prism:startingPage":"1233","prism:endingPage":"1240"},"reviewed":"false","url":[{"@id":"https://syndication.highwire.org/content/doi/10.1261/rna.1528909"}],"createdAt":"2009-05-28","modifiedAt":"2021-11-21","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360017282214230784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Importin/exportin-mediated nucleocytoplasmic shuttling of cucumber mosaic virus 2b protein is required for 2b’s efficient suppression of RNA silencing"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283690829812224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Poly(A)-Specific Ribonuclease Mediates 3′-End Trimming of Argonaute2-Cleaved Precursor MicroRNAs"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285709519746176","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"SHARAKU: an algorithm for aligning and clustering read mapping profiles of deep sequencing in non-coding RNA processing"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567187481655680","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Generation of a Mouse Model with Down-Regulated U50 snoRNA (SNORD50) Expression and Its Organ-Specific Phenotypic Modulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580230584722432","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Long non-coding RNAs: definitions, functions, challenges and recommendations"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1261/rna.1528909"},{"@type":"CROSSREF","@value":"10.1371/journal.ppat.1010267_references_DOI_KUi5lXnMsOdJNUWx37WBa9Okr6g"},{"@type":"CROSSREF","@value":"10.1093/bioinformatics/btw273_references_DOI_KUi5lXnMsOdJNUWx37WBa9Okr6g"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0072105_references_DOI_KUi5lXnMsOdJNUWx37WBa9Okr6g"},{"@type":"CROSSREF","@value":"10.1038/s41580-022-00566-8_references_DOI_KUi5lXnMsOdJNUWx37WBa9Okr6g"},{"@type":"CROSSREF","@value":"10.1016/j.celrep.2013.09.029_references_DOI_KUi5lXnMsOdJNUWx37WBa9Okr6g"}]}