{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699995157465600.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1159/000166995"}},{"identifier":{"@type":"URI","@value":"https://www.karger.com/Article/Pdf/166995"}},{"identifier":{"@type":"PMID","@value":"18957871"}}],"dc:title":[{"@value":"Implantation of Dedifferentiated Fat Cells Ameliorates Habu Snake Venom-Induced Chronic Renal Dysfunction in Tenascin-C-Deficient Mice"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p><i>Background/Aims:</i> We established dedifferentiated fat (DFAT) cells from mature adipocytes that differentiate to multiple lineages and have characteristics similar to those of mesenchymal stem cells. In this study, we evaluated the effect of implantation of DFAT cells on habu snake venom (HSV)-induced renal dysfunction in tenascin-C knockout (TC-KO) mice. <i>Methods:</i> Cultured DFAT cells were incubated with PDGF-BB and immunostained with anti-desmin antibody to determine mesenchymal differentiation. HSV was injected, and DFAT cells from GFP mice were implanted in TC-KO mice via the tail vein. Expression of tenascin-C, transforming growth factor-β<sub>1</sub> (TGF-β1), and fibronectin mRNAs in the renal cortex were evaluated by RT-PCR analysis. <i>Results:</i> Cultured DFAT cells showed desmin immunostaining in response to PDGF-BB.HSV injection induced glomerulosclerosis, which was significantly improved by implantation of DFAT cells. Serum BUN increased after HSV injection and was significantly decreased by implantation of DFAT cells. Tenascin-C mRNA was detected in the renal cortex in implanted mice. Expression of TGF-β1 and fibronectin mRNAs increased in the renal cortex after HSV injection, and was significantly decreased by implantation of DFAT cells. <i>Conclusion:</i> DFAT cells may provide a source for cell therapy for severe progressive renal disease.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699995157465473","@type":"Researcher","foaf:name":[{"@value":"Renaguli Nur"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801196947200","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40267050"},{"@type":"NRID","@value":"1000040267050"},{"@type":"NRID","@value":"9000004082931"},{"@type":"NRID","@value":"9000022137554"},{"@type":"NRID","@value":"9000021994532"},{"@type":"NRID","@value":"9000020558760"},{"@type":"NRID","@value":"9000254638741"},{"@type":"NRID","@value":"9000014488836"},{"@type":"NRID","@value":"9000020030917"},{"@type":"NRID","@value":"9000261022320"},{"@type":"NRID","@value":"9000016963109"},{"@type":"NRID","@value":"9000311506136"},{"@type":"NRID","@value":"9000405896063"},{"@type":"NRID","@value":"9000255844396"},{"@type":"NRID","@value":"9000008347417"},{"@type":"NRID","@value":"9000020757526"},{"@type":"NRID","@value":"9000020759600"},{"@type":"NRID","@value":"9000256094416"},{"@type":"NRID","@value":"9000021835146"},{"@type":"NRID","@value":"9000240038117"},{"@type":"NRID","@value":"9000001014431"},{"@type":"NRID","@value":"9000006098918"},{"@type":"NRID","@value":"9000346935816"},{"@type":"NRID","@value":"9000253223464"},{"@type":"NRID","@value":"9000253224774"},{"@type":"NRID","@value":"9000257776394"},{"@type":"NRID","@value":"9000258726985"},{"@type":"NRID","@value":"9000020782223"},{"@type":"NRID","@value":"9000021816179"},{"@type":"NRID","@value":"9000254171225"},{"@type":"NRID","@value":"9000283693784"},{"@type":"NRID","@value":"9000018238440"},{"@type":"NRID","@value":"9000003981064"},{"@type":"NRID","@value":"9000022039022"},{"@type":"NRID","@value":"9000254099335"},{"@type":"NRID","@value":"9000256094329"},{"@type":"NRID","@value":"9000378656358"},{"@type":"NRID","@value":"9000020782962"},{"@type":"NRID","@value":"9000257808514"},{"@type":"NRID","@value":"9000252823243"},{"@type":"NRID","@value":"9000254975855"},{"@type":"NRID","@value":"9000256086862"},{"@type":"NRID","@value":"9000002855565"},{"@type":"NRID","@value":"9000253226047"},{"@type":"NRID","@value":"9000399498190"},{"@type":"NRID","@value":"9000257808779"},{"@type":"NRID","@value":"9000021944389"},{"@type":"NRID","@value":"9000021203143"},{"@type":"NRID","@value":"9000020480551"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0184223"}],"foaf:name":[{"@value":"Noboru Fukuda"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995157465472","@type":"Researcher","foaf:name":[{"@value":"Taro Matsumoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995157465602","@type":"Researcher","foaf:name":[{"@value":"Jumabay Medet"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995157465603","@type":"Researcher","foaf:name":[{"@value":"Koichiro Kano"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995157465604","@type":"Researcher","foaf:name":[{"@value":"Chii Yamamoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995157465474","@type":"Researcher","foaf:name":[{"@value":"Takashi Maruyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995157465475","@type":"Researcher","foaf:name":[{"@value":"Morito Endo"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995157465600","@type":"Researcher","foaf:name":[{"@value":"Koichi Matsumoto"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"16602129"}],"prism:publicationName":[{"@value":"Nephron Experimental Nephrology"}],"dc:publisher":[{"@value":"S. Karger AG"}],"prism:publicationDate":"2008-10-27","prism:volume":"110","prism:number":"3","prism:startingPage":"e91","prism:endingPage":"e98"},"reviewed":"false","dc:rights":["https://www.karger.com/Services/SiteLicenses","https://www.karger.com/Services/SiteLicenses"],"url":[{"@id":"https://www.karger.com/Article/Pdf/166995"}],"createdAt":"2008-10-27","modifiedAt":"2025-04-23","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Knockout","dc:title":"Mice, Knockout"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Adipocytes","dc:title":"Adipocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Tenascin","dc:title":"Tenascin"},{"@id":"https://cir.nii.ac.jp/all?q=Acute%20Kidney%20Injury","dc:title":"Acute Kidney Injury"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Dedifferentiation","dc:title":"Cell Dedifferentiation"},{"@id":"https://cir.nii.ac.jp/all?q=Snake%20Venoms","dc:title":"Snake Venoms"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285706520867840","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Current status of drug therapies for osteoporosis and the search for stem cells adapted for bone regenerative medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707518775936","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Phenotypic and functional properties of feline dedifferentiated fat cells and adipose-derived stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285711821012608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Systematic implantation of dedifferentiated fat cells ameliorated monoclonal antibody 1-22-3-induced glomerulonephritis by immunosuppression with increases in TNF-stimulated gene 6"}]},{"@id":"https://cir.nii.ac.jp/crid/1360286992237579392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Dedifferentiated fat cells in polyglycolic acid-collagen nerve conduits promote rat facial nerve regeneration"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206433354752","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Development of Novel Therapeutic Strategies to Prevent the Development of Kidney Disease"},{"@language":"ja","@value":"腎疾患の進展阻止を目指した新しい治療戦略の開発"},{"@language":"ja-Kana","@value":"ジンシッカン ノ シンテン ソシ オ メザシタ アタラシイ チリョウ センリャク ノ カイハツ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681408560640","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"脱分化脂肪細胞を用いた再生医療"},{"@language":"en","@value":"Regenerative Medicine using Dedifferentiated fat Cells"},{"@value":"平成21年日本大学医学会秋季学術大会 同窓会学術奨励賞受賞講演 脱分化脂肪細胞を用いた再生医療"},{"@language":"ja-Kana","@value":"ヘイセイ 21ネン ニホン ダイガク イガッカイ シュウキ ガクジュツ タイカイ ドウソウカイ ガクジュツ ショウレイショウ ジュショウ コウエン ダツブンカ シボウ サイボウ オ モチイタ サイセイ イリョウ"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1159/000166995"},{"@type":"OPENAIRE","@value":"doi_dedup___::5c8e7754d68f9e523bce34df46d8081e"},{"@type":"CROSSREF","@value":"10.1016/j.tvjl.2013.10.033_references_DOI_Pb6KzCpDGzfj7UHPCUdOgz2c0kh"},{"@type":"CROSSREF","@value":"10.4264/numa.68.315_references_DOI_Pb6KzCpDGzfj7UHPCUdOgz2c0kh"},{"@type":"CROSSREF","@value":"10.4264/numa.69.122_references_DOI_Pb6KzCpDGzfj7UHPCUdOgz2c0kh"},{"@type":"CROSSREF","@value":"10.1007/s12565-013-0208-8_references_DOI_Pb6KzCpDGzfj7UHPCUdOgz2c0kh"},{"@type":"CROSSREF","@value":"10.1186/s13287-015-0069-2_references_DOI_Pb6KzCpDGzfj7UHPCUdOgz2c0kh"},{"@type":"CROSSREF","@value":"10.1016/j.reth.2019.08.004_references_DOI_Pb6KzCpDGzfj7UHPCUdOgz2c0kh"}]}