{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699995199816448.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1146/annurev.immunol.021908.132532"}},{"identifier":{"@type":"URI","@value":"https://www.annualreviews.org/doi/pdf/10.1146/annurev.immunol.021908.132532"}}],"dc:title":[{"@value":"Alternative Activation of Macrophages: An Immunologic Functional Perspective"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Macrophages are innate immune cells with well-established roles in the primary response to pathogens, but also in tissue homeostasis, coordination of the adaptive immune response, inflammation, resolution, and repair. These cells recognize danger signals through receptors capable of inducing specialized activation programs. The classically known macrophage activation is induced by IFN-γ, which triggers a harsh proinflammatory response that is required to kill intracellular pathogens. Macrophages also undergo alternative activation by IL-4 and IL-13, which trigger a different phenotype that is important for the immune response to parasites. Here we review the cellular sources of these cytokines, receptor signaling pathways, and induced markers and gene signatures. We draw attention to discrepancies found between mouse and human models of alternative activation. The evidence for in vivo alternative activation of macrophages is also analyzed, with nematode infection as prototypic disease. Finally, we revisit the concept of macrophage activation in the context of the immune response.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699995199816450","@type":"Researcher","foaf:name":[{"@value":"Fernando O. Martinez"}],"jpcoar:affiliationName":[{"@value":"Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom;,"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995199816448","@type":"Researcher","foaf:name":[{"@value":"Laura Helming"}],"jpcoar:affiliationName":[{"@value":"Institute for Medical Microbiology, Immunology and Hygiene, Technical University Munich, Munich 81675, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995199816449","@type":"Researcher","foaf:name":[{"@value":"Siamon Gordon"}],"jpcoar:affiliationName":[{"@value":"Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom;,"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"07320582"},{"@type":"EISSN","@value":"15453278"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/07320582"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/07320582"}],"prism:publicationName":[{"@value":"Annual Review of Immunology"}],"dc:publisher":[{"@value":"Annual Reviews"}],"prism:publicationDate":"2009-04-01","prism:volume":"27","prism:number":"1","prism:startingPage":"451","prism:endingPage":"483"},"reviewed":"false","url":[{"@id":"https://www.annualreviews.org/doi/pdf/10.1146/annurev.immunol.021908.132532"}],"createdAt":"2008-12-23","modifiedAt":"2023-05-23","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050011251823172480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Gpr137b is an orphan G-protein-coupled receptor associated with M2 macrophage polarization"}]},{"@id":"https://cir.nii.ac.jp/crid/1050282810795487616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Role of IL13RA2 in Sunitinib Resistance in Clear Cell Renal Cell Carcinoma."}]},{"@id":"https://cir.nii.ac.jp/crid/1050301297461548800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss"}]},{"@id":"https://cir.nii.ac.jp/crid/1050304183898510720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors"}]},{"@id":"https://cir.nii.ac.jp/crid/1050845760765724544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Aquaporin-3 potentiates allergic airway inflammation in ovalbumin-induced murine asthma"}]},{"@id":"https://cir.nii.ac.jp/crid/1050856995322700160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Intraepithelial CD163+ macrophages in tongue leukoplakia biopsy: A promising tool for cancer screening"},{"@value":"Intraepithelial CD163<sup>+</sup> macrophages in tongue leukoplakia biopsy: A promising tool for cancer screening"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002216080223744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Constitutive high expression of interleukin-4/13A and GATA-3 in gill and skin of salmonid fishes suggests that these tissues form Th2-skewed immune environments"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002217680953472","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Secreted protein lipocalin‐2 promotes microglial M1 polarization"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002219400219136","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Rapid Host Defense against Aspergillus fumigatus Involves Alveolar Macrophages with a Predominance of Alternatively Activated Phenotype"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002219454825600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Assembly of EDC4 and Dcp1a into Processing Bodies Is Critical for the Translational Regulation of IL-6"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002219689065216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Inflammatory monocytes promote progression of Duchenne muscular dystrophy and can be therapeutically targeted via\n                    <scp>CCR</scp>\n                    2"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004230159036672","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Transplantation of Noncultured Stromal Vascular Fraction Cells of Adipose Tissue Ameliorates Osteonecrosis of the Jaw–Like Lesions in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004231142511616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Periostin in vitreoretinal diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004231260630784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Possible involvement of Toll-like receptor 7 in the development of type 1 autoimmune pancreatitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004231564672128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004231952857344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Chitinase Inhibition Promotes Atherosclerosis in Hyperlipidemic Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232160389888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Astrocytic mobilization of glutathione peroxidase-1 contributes to the protective potential against cocaine kindling behaviors in mice via activation of JAK2/STAT3 signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233458938368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pirfenidone prevents and reverses hepatic insulin resistance and steatohepatitis by polarizing M2 macrophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004236649080832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Immunophenotypical Characterization of Macrophages in Rat Bleomycin-Induced Scleroderma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004239199963392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Characteristics of alveolar macrophages from murine models of OVA-induced allergic airway inflammation and LPS-induced acute airway inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004239510694656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Lactobacillus paracasei KW3110 Prevents Blue Light-Induced Inflammation and Degeneration in the Retina"}]},{"@id":"https://cir.nii.ac.jp/crid/1360005742501962880","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The enhancement of CCL2 and CCL5 by human bone marrow-derived mesenchymal stem/stromal cells might contribute to inflammatory suppression and axonal extension after spinal cord injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168774656768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Laminin Isoforms in Human Dental Pulp: Lymphatic Vessels Express Laminin-332, and Schwann Cell–Associated Laminin-211 Modulates CD163 Expression of M2-like Macrophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168850227200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Role of tumor‐associated macrophages at the invasive front in human colorectal cancer progression"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021390767412480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Downregulation of pattern recognition receptors on macrophages involved in aggravation of endometriosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283690766688256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Transfusion of CD206+ M2 Macrophages Ameliorates Antibody-Mediated Glomerulonephritis in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691773007744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neutrophils negatively regulate induction of mucosal IgA responses after sublingual immunization"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283692108375808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693708275584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"MicroRNA‐33 Deficiency Reduces the Progression of Atherosclerotic Plaque in ApoE\n            <sup>−/−</sup>\n            Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693977146112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Human mesenchymal stem/stromal cells suppress spinal inflammation in mice with contribution of pituitary adenylate cyclase-activating polypeptide (PACAP)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706909427328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Biology of GM3 Ganglioside"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706959211392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Amelogenin induces M2 macrophage polarisation via PGE2/cAMP signalling pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706977159296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Th2-inducing cytokines IL-4 and IL-33 synergistically elicit the expression of transmembrane TNF-α on macrophages through the autocrine action of IL-6"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285709641863808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Macrophages regulate expression of  1,2-fucosyltransferase genes in human endometrial epithelial cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710763371136","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Innate immune cells in reproduction"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285711022506752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Increased expression of M-CSF and IL-13 in vitreous of patients with proliferative diabetic retinopathy: implications for M2 macrophage-involving fibrovascular membrane formation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360286994471662336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Zinc Deficiency Activates the IL-23/Th17 Axis to Aggravate Experimental Colitis in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165923726208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"IL-27 promotes nitric oxide production induced by LPS through STAT1, NF-κB and MAPKs"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166752260480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166755995520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168291894016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Targeting innate immunity for neurodegenerative disorders of the central nervous system"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168930828288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565170866424064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Protective Role of STAT6 in Basophil-Dependent Prurigo-like Allergic Skin Inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181549839488","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Novel insights into the role of immune cells in skin and inducible skin-associated lymphoid tissue (iSALT)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567184264441728","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effects of STING stimulation on macrophages: STING agonists polarize into “classically” or “alternatively” activated macrophages?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567189164243200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Induction of thymic stromal lymphopoietin in mesenchymal stem cells by interaction with myeloma cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092695712128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Lipopolysaccharide preconditioning reduces liver metastasis of Colon26 cells by enhancing antitumor activity of natural killer cells and natural killer T cells in murine liver"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092861702400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Harmful and beneficial effects of inflammatory response on reproduction: sterile and pathogen-associated inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092861814400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Inappropriate activation of invariant natural killer T cells and antigen‐presenting cells with the elevation of HMGB1 in preterm births without acute chorioamnionitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232166500992","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Reduced phagocytic activity of human alveolar macrophages infected with Mycobacterium avium complex"}]},{"@id":"https://cir.nii.ac.jp/crid/1360845539130837760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Overexpression of CD163 in vitreous and fibrovascular membranes of patients with proliferative diabetic retinopathy: possible involvement of periostin"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846639504862208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Macrophages—Key cells in the response to wear debris from joint replacements"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640900817280","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Inflammatory Monocytes Recruited to Allergic Skin Acquire an Anti-inflammatory M2 Phenotype via Basophil-Derived Interleukin-4"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643058706688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Subversion of host cellular functions by the apicomplexan parasites"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643083513216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Macrophages control innate inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643285116288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Role of tumor‐associated macrophages in human malignancies: friend or foe?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846644352978048","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Autocrine Regulation of Macrophage Activation via Exocytosis of ATP and Activation of P2Y11 Receptor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846644367174784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Overexpression of CD163, CD204 and CD206 on Alveolar Macrophages in the Lungs of Patients with Severe Chronic Obstructive Pulmonary Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848655087291264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Modulation of mouse macrophage polarization<i>in vitro</i>using IL-4 delivery by osmotic pumps"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848655157336064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Taurine improves obesity‐induced inflammatory responses and modulates the unbalanced phenotype of adipose tissue macrophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848659521319168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Control of homeostatic and pathogenic balance in adipose tissue by ganglioside GM3"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848659542252928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Th2-type inflammation instructs inflammatory dendritic cells to induce airway hyperreactivity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848660464433152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Recent advances in understanding basophil‐mediated Th2 immune responses"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848660709179008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Preventive effect of agaro‐oligosaccharides on non‐steroidal anti‐inflammatory drug‐induced small intestinal injury in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848660713665152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cathepsin C modulates myelin oligodendrocyte glycoprotein‐induced experimental autoimmune encephalomyelitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848661258781184","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A functional (pro)renin receptor is expressed in human lymphocytes and monocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567393212288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Inflammation related to high-mobility group box-1 in endometrial ovarian cyst"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593700935680","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Aging-associated inflammation and fibrosis in arachnoid membrane"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707131566208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cilia‐Mediated Insulin/Akt and ST2/JNK Signaling Pathways Regulate the Recovery of Muscle Injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1361412890377731456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Periostin in Eye Diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1361694371619527808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"M1 macrophage is the predominant phenotype in coronary artery lesions following Kawasaki disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204627081088","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Icariin Derivative Inhibits Inflammation through Suppression of p38 Mitogen-Activated Protein Kinase and Nuclear Factor-.KAPPA.B Pathways"},{"@value":"Icariin derivative inhibits inflammation through suppression of p38 mitogen-activated protein kinase and nuclear factor-κB pathways"},{"@language":"ja-Kana","@value":"Icariin derivative inhibits inflammation through suppression of p38 mitogen activated protein kinase and nuclear factor k B pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204705051520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Role of Tumor-Associated Macrophages on Serum Soluble IL-2R Levels in B-Cell Lymphomas"}]},{"@id":"https://cir.nii.ac.jp/crid/1390564238081827200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Tris (1,3-dichloro-2-propyl) phosphate treatment induces DNA damage, cell cycle arrest and apoptosis in murine RAW264.7 macrophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1390849931327942400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The multiple functions and subpopulations of eosinophils in tissues under steady-state and pathological conditions"}]},{"@id":"https://cir.nii.ac.jp/crid/1390854882571137024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The role of iron in obesity and diabetes"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1146/annurev.immunol.021908.132532"},{"@type":"CROSSREF","@value":"10.1038/s41467-017-00231-1_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1096/fj.12-222257_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0015943_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0123223_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.15252/emmm.201403967_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1002/jbmr.3292_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1007/s00018-017-2651-5_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1007/s00535-014-0977-4_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1007/s13340-015-0213-3_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1038/s41374-019-0255-4_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1177/0300985812450718_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.3109/01902148.2015.1044137_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.3390/nu10121991_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1016/bs.pmbts.2017.10.004_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0230080_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1016/j.molimm.2011.02.014_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1111/cas.14940_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1111/aji.13812_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1038/mi.2014.105_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1073/pnas.1113099109_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1161/jaha.112.003376_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1186/s12974-015-0252-5_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1093/molehr/gar070_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1111/jog.13759_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1136/bjophthalmol-2014-305860_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1248/bpb.33.1307_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.3960/jslrt.54.49_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1093/ecco-jcc/jjz193_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1016/j.imbio.2012.07.028_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1016/j.actbio.2020.12.046_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.2131/jts.44.134_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.2152/jmi.69.1_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1038/nature11930_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1038/ncomms13130_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1111/jnc.13667_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1186/1742-2094-9-65_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.4049/jimmunol.1401032_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1007/s40629-015-0065-1_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1038/srep25781_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1080/21645515.2017.1395995_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.3109/10428194.2014.881478_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1016/j.alit.2020.11.001_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1016/j.freeradbiomed.2018.12.027_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1111/jgh.15375_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1080/25785826.2020.1809951_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1111/aji.13330_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1016/j.jiac.2022.07.018_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1136/bjophthalmol-2014-305321_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1002/jbm.a.34599_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1111/1574-6976.12013_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1111/dom.12151_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1111/pin.12440_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0059778_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0087400_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1002/jbm.a.35278_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1002/mnfr.201300150_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1093/glycob/cwu112_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1093/intimm/dxt047_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1111/imr.12548_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1111/jgh.12373_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1111/jnc.14581_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1152/ajprenal.00206.2014_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0130980_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1016/j.jri.2021.103292_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1186/s12883-021-02202-y_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.4049/immunohorizons.2100110_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1002/advs.202202632_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1007/978-981-13-6657-4_12_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1111/odi.13269_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2018.12.140_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1177/1358863x19878495_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1016/j.archoralbio.2017.08.005_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2012.02.124_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1016/j.immuni.2012.11.014_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1016/j.ajpath.2016.08.012_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"},{"@type":"CROSSREF","@value":"10.1016/j.ajpath.2013.04.003_references_DOI_C23Q6FEjJmkOWQBNGGtvg3kkEEX"}]}