{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699995232860160.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/s0304-3940(01)02476-4"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0304394001024764?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0304394001024764?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"11796186"}}],"dc:title":[{"@value":"Plasma orexin-A is lower in patients with narcolepsy"}],"description":[{"notation":[{"@value":"Recently identified hypothalamic peptides called orexins (or hypocretins) have been implicated in the sleep-wake cycle and in sleep disorder narcolepsy. Neuropathological studies have shown that in patients with narcolepsy, global reduction in the expression of orexins occurs due to the loss of orexin neurons in the hypothalamus. Cerebrospinal fluid analysis has confirmed a reduced or undetectable level of orexin-A in most narcolepsy patients. In this study, measurement of plasma orexin showed significantly lower concentrations in patients with narcolepsy than in age- and gender-matched normal controls. These data suggest that low levels of orexin-A in plasma could serve as a biological marker for narcolepsy."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699995232860166","@type":"Researcher","foaf:name":[{"@value":"S Higuchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995232860165","@type":"Researcher","foaf:name":[{"@value":"A Usui"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995232860164","@type":"Researcher","foaf:name":[{"@value":"M Murasaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995232860170","@type":"Researcher","foaf:name":[{"@value":"S Matsushita"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995232860168","@type":"Researcher","foaf:name":[{"@value":"N Nishioka"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995232860169","@type":"Researcher","foaf:name":[{"@value":"A Yoshino"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995232860167","@type":"Researcher","foaf:name":[{"@value":"T Matsui"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995232860161","@type":"Researcher","foaf:name":[{"@value":"H Muraoka"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995232860162","@type":"Researcher","foaf:name":[{"@value":"Y Ishizuka"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995232860163","@type":"Researcher","foaf:name":[{"@value":"S Kanba"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995232860160","@type":"Researcher","foaf:name":[{"@value":"T Sakurai"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03043940"}],"prism:publicationName":[{"@value":"Neuroscience Letters"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2002-01","prism:volume":"318","prism:number":"2","prism:startingPage":"61","prism:endingPage":"64"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0304394001024764?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0304394001024764?httpAccept=text/plain"}],"createdAt":"2002-10-14","modifiedAt":"2020-01-08","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Neurons","dc:title":"Neurons"},{"@id":"https://cir.nii.ac.jp/all?q=Orexins","dc:title":"Orexins"},{"@id":"https://cir.nii.ac.jp/all?q=Neuropeptides","dc:title":"Neuropeptides"},{"@id":"https://cir.nii.ac.jp/all?q=Hypothalamus","dc:title":"Hypothalamus"},{"@id":"https://cir.nii.ac.jp/all?q=Intracellular%20Signaling%20Peptides%20and%20Proteins","dc:title":"Intracellular Signaling Peptides and Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Down-Regulation","dc:title":"Down-Regulation"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Carrier%20Proteins","dc:title":"Carrier Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Narcolepsy","dc:title":"Narcolepsy"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004232391805440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Plasma orexin A increases at emergence from sevoflurane-fentanyl anesthesia in patients undergoing ophthalmologic surgery"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283692504195456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Changes in plasma orexin A during propofol–fentanyl anaesthesia in patients undergoing eye surgery"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185771569920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Plasma orexin‐A levels in patients with delirium"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679461334912","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Plasma Levels of Orexin-A and Leptin in Obese Children"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/s0304-3940(01)02476-4"},{"@type":"OPENAIRE","@value":"doi_dedup___::90669b62086a69dd6c8106f9701be8ce"},{"@type":"CROSSREF","@value":"10.1016/j.neulet.2010.07.037_references_DOI_RPwgYdKtErimMOctebyp9Aj7bnk"},{"@type":"CROSSREF","@value":"10.1111/psyg.12444_references_DOI_RPwgYdKtErimMOctebyp9Aj7bnk"},{"@type":"CROSSREF","@value":"10.1297/cpe.13.47_references_DOI_RPwgYdKtErimMOctebyp9Aj7bnk"},{"@type":"CROSSREF","@value":"10.1093/bja/aeq098_references_DOI_RPwgYdKtErimMOctebyp9Aj7bnk"}]}