{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699995377394304.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/s0092-8674(00)80949-6"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0092867400809496?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0092867400809496?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"9491897"}},{"identifier":{"@type":"PMID","@value":"25728437"}},{"identifier":{"@type":"NAID","@value":"30010682494"}}],"dc:title":[{"@value":"Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior"}],"description":[{"notation":[{"@value":"The hypothalamus plays a central role in the integrated control of feeding and energy homeostasis. We have identified two novel neuropeptides, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (previously) orphan G protein-coupled receptors. These peptides, termed orexin-A and -B, have no significant structural similarities to known families of regulatory peptides. prepro-orexin mRNA and immunoreactive orexin-A are localized in neurons within and around the lateral and posterior hypothalamus in the adult rat brain. When administered centrally to rats, these peptides stimulate food consumption. prepro-orexin mRNA level is up-regulated upon fasting, suggesting a physiological role for the peptides as mediators in the central feedback mechanism that regulates feeding behavior."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699995377394304","@type":"Researcher","foaf:name":[{"@value":"Takeshi Sakurai"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995377394305","@type":"Researcher","foaf:name":[{"@value":"Akira Amemiya"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995377394183","@type":"Researcher","foaf:name":[{"@value":"Makoto Ishii"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995377394176","@type":"Researcher","foaf:name":[{"@value":"Ichiyo Matsuzaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995377394306","@type":"Researcher","foaf:name":[{"@value":"Richard M Chemelli"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995377394182","@type":"Researcher","foaf:name":[{"@value":"Hirokazu Tanaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995377394312","@type":"Researcher","foaf:name":[{"@value":"S.Clay Williams"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995377394315","@type":"Researcher","foaf:name":[{"@value":"James A Richardson"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995377394177","@type":"Researcher","foaf:name":[{"@value":"Gerald P Kozlowski"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995377394310","@type":"Researcher","foaf:name":[{"@value":"Shelagh Wilson"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995377394309","@type":"Researcher","foaf:name":[{"@value":"Jonathan R.S Arch"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995377394313","@type":"Researcher","foaf:name":[{"@value":"Robin E Buckingham"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995377394179","@type":"Researcher","foaf:name":[{"@value":"Andrea C Haynes"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995377394314","@type":"Researcher","foaf:name":[{"@value":"Steven A Carr"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995377394311","@type":"Researcher","foaf:name":[{"@value":"Roland S Annan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995377394180","@type":"Researcher","foaf:name":[{"@value":"Dean E McNulty"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995377394181","@type":"Researcher","foaf:name":[{"@value":"Wu-Schyong Liu"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995377394307","@type":"Researcher","foaf:name":[{"@value":"Jonathan A Terrett"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995377394178","@type":"Researcher","foaf:name":[{"@value":"Nabil A Elshourbagy"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995377394184","@type":"Researcher","foaf:name":[{"@value":"Derk J Bergsma"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995377394308","@type":"Researcher","foaf:name":[{"@value":"Masashi Yanagisawa"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00928674"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00928674"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/00928674"}],"prism:publicationName":[{"@value":"Cell"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"1998-02","prism:volume":"92","prism:number":"4","prism:startingPage":"573","prism:endingPage":"585"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://www.elsevier.com/open-access/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0092867400809496?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0092867400809496?httpAccept=text/plain"}],"createdAt":"2004-04-10","modifiedAt":"2025-09-25","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Neuropeptide","dc:title":"Receptors, Neuropeptide"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Sequence%20Data","dc:title":"Molecular Sequence Data"},{"@id":"https://cir.nii.ac.jp/all?q=Hypothalamus","dc:title":"Hypothalamus"},{"@id":"https://cir.nii.ac.jp/all?q=CHO%20Cells","dc:title":"CHO Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Kidney","dc:title":"Kidney"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20G-Protein-Coupled","dc:title":"Receptors, G-Protein-Coupled"},{"@id":"https://cir.nii.ac.jp/all?q=GTP-Binding%20Proteins","dc:title":"GTP-Binding Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Orexin%20Receptors","dc:title":"Orexin Receptors"},{"@id":"https://cir.nii.ac.jp/all?q=Cricetinae","dc:title":"Cricetinae"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=RNA,%20Messenger","dc:title":"RNA, Messenger"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Precursors","dc:title":"Protein Precursors"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Wistar","dc:title":"Rats, Wistar"},{"@id":"https://cir.nii.ac.jp/all?q=Chromatography,%20High%20Pressure%20Liquid","dc:title":"Chromatography, High Pressure Liquid"},{"@id":"https://cir.nii.ac.jp/all?q=Neurons","dc:title":"Neurons"},{"@id":"https://cir.nii.ac.jp/all?q=Neurotransmitter%20Agents","dc:title":"Neurotransmitter Agents"},{"@id":"https://cir.nii.ac.jp/all?q=Orexins","dc:title":"Orexins"},{"@id":"https://cir.nii.ac.jp/all?q=Sequence%20Homology,%20Amino%20Acid","dc:title":"Sequence Homology, Amino Acid"},{"@id":"https://cir.nii.ac.jp/all?q=Biochemistry,%20Genetics%20and%20Molecular%20Biology(all)","dc:title":"Biochemistry, Genetics and Molecular Biology(all)"},{"@id":"https://cir.nii.ac.jp/all?q=Neuropeptides","dc:title":"Neuropeptides"},{"@id":"https://cir.nii.ac.jp/all?q=Intracellular%20Signaling%20Peptides%20and%20Proteins","dc:title":"Intracellular Signaling Peptides and Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Fasting","dc:title":"Fasting"},{"@id":"https://cir.nii.ac.jp/all?q=Feeding%20Behavior","dc:title":"Feeding Behavior"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Rabbits","dc:title":"Rabbits"},{"@id":"https://cir.nii.ac.jp/all?q=Carrier%20Proteins","dc:title":"Carrier Proteins"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001202640475392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Odour-induced analgesia mediated by hypothalamic orexin neurons in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1050001335950919168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Overview of orexin/hypocretin system"}]},{"@id":"https://cir.nii.ac.jp/crid/1050001335953757696","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation"}]},{"@id":"https://cir.nii.ac.jp/crid/1050003824955205120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Effects of Mutual Interaction of Orexin-A and Glucagon-Like Peptide-1 on Reflex Swallowing Induced by SLN Afferents in Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1050004225379052544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1050006740568714496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Orexin A Enhances Pro-Opiomelanocortin Transcription Regulated by BMP-4 in Mouse Corticotrope AtT20 Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1050282677626691712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Comprehensive Behavioral Analysis of Male Ox1r-/- Mice Showed Implication of Orexin Receptor-1 in Mood Anxiety and Social Behavior"},{"@value":"Comprehensive Behavioral Analysis of Male Ox1r−/− Mice Showed Implication of Orexin Receptor-1 in Mood, Anxiety, and Social Behavior"},{"@value":"Comprehensive behavioral analysis of Ox1r-/- mice showed implication of orexin receptor-1 in mood, anxiety and social behavior."}]},{"@id":"https://cir.nii.ac.jp/crid/1050282813782585600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Hypothalamic regulation of the sleep/wake cycle"}]},{"@id":"https://cir.nii.ac.jp/crid/1050303321522120832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Function of orexin-1 receptor signaling in the olfactory tubercle in odor-guided attraction and aversion"}]},{"@id":"https://cir.nii.ac.jp/crid/1050305798591219968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Design and Synthesis of Orexin 1 Receptor-Selective Agonists"}]},{"@id":"https://cir.nii.ac.jp/crid/1050564285907135744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The roles of orexins in sleep/wake regulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1050570387114291968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Orexin A and B in the rat superior salivatory nucleus"}]},{"@id":"https://cir.nii.ac.jp/crid/1050576282633255680","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Thermoregulation under pressure: a role for orexin neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1050587981433132672","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Hypothalamic prepro-orexin mRNA level is inversely correlated to the non-rapid eye movement sleep level in high-fat diet-induced obese mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1050845760751725184","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour."}]},{"@id":"https://cir.nii.ac.jp/crid/1050845760881089920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Orexin (Hypocretin) receptor agonists and antagonists for treatment of sleep disorders: Rationale for development and current status"}]},{"@id":"https://cir.nii.ac.jp/crid/1050845760883888000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal"}]},{"@id":"https://cir.nii.ac.jp/crid/1050848650293700224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Differential Roles of Each Orexin Receptor Signaling in Obesity"},{"@value":"Differential roles of each orexin receptor signaling in obesity differential roles of each orexin receptor signaling in obesity."}]},{"@id":"https://cir.nii.ac.jp/crid/1050866117150690688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Synaptic plasticity and roles of orexin in distinct domains of the olfactory tubercle"}]},{"@id":"https://cir.nii.ac.jp/crid/1050867133850601600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Role of orexin in exercise-induced leptin sensitivity in the mediobasal hypothalamus of mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002219065029248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neurosecretory Protein GL, a Hypothalamic Small Secretory Protein, Participates in Energy Homeostasis in Male Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002219669994880","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Conditional Ablation of Orexin/Hypocretin Neurons: A New Mouse Model for the Study of Narcolepsy and Orexin System Function"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002221192268672","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Progressive Loss of the Orexin Neurons Reveals Dual Effects on Wakefulness"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004230071771392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Anatomical and electrophysiological development of the hypothalamic orexin neurons from embryos to neonates"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004231882397696","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Orphan GPCRs and Methods for Identifying Their Ligands"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232017241216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232017283200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232024208512","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Antinociceptive action against colonic distension by brain orexin in conscious rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232078640128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Lateral hypothalamic circuits for sleep–wake control"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232325348608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neurobiological Basis of Hypersomnia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232393763456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Ectopic expression of melanopsin in orexin/hypocretin neurons enables control of wakefulness of mice in vivo by blue light"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232393932288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Sleep in vertebrate and invertebrate animals, and insights into the function and evolution of sleep"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232393939840","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Increased oxytocin-monomeric red fluorescent protein 1 fluorescent intensity with urocortin-like immunoreactivity in the hypothalamo-neurohypophysial system of aged transgenic rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232478394624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Orexin induces excitation of respiratory neuronal network in isolated brainstem spinal cord of neonatal rat"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233491292800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Lateral parabrachial neurons innervate orexin neurons projecting to brainstem arousal areas in the rat"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233525067904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The odor of Osmanthus fragrans attenuates food intake"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235841543296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Orexin neurons are indispensable for prostaglandin E<sub>2</sub>‐induced fever and defence against environmental cooling in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004236401551232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Involvement of the Orexin System in Adrenal Sympathetic Regulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360005516690959104","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360005516690987904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group"}]},{"@id":"https://cir.nii.ac.jp/crid/1360005517156772736","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Brain orexin improves intestinal barrier function via the vagal cholinergic pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1360005517198328704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Orexin A modulates prolactin production by regulating BMP-4 activity in rat pituitary lactotorope cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142565995648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Centrally administered orexin prevents lipopolysaccharide and colchicine induced lethality via the vagal cholinergic pathway in a sepsis model in rats"},{"@language":"en","@value":"10.1016/j.bcp.2020.114262"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142566304384","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Central regulatory mechanisms of visceral sensation in response to colonic distension with special reference to brain orexin"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142608168832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Design and Synthesis of Novel Orexin Antagonists via Structural Simplification of the Morphinan Skeleton"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142622449920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"RF-amide related peptide-3 (RFRP-3): a novel neuroendocrine regulator of energy homeostasis, metabolism, and reproduction"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142851023872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Orexin system is expressed in avian liver and regulates hepatic lipogenesis via ERK1/2 activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168718272640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Application of Kampo medicines for the palliation of cancer cachexia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013172911689728","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinans bearing multiple effective residues (TriMER) library"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017282188156672","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Molecular basis for anti-insomnia drug design from structure of lemborexant-bound orexin 2 receptor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021389806805632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Whole Brain Mapping of Orexin Receptor mRNA Expression Visualized by Branched In Situ Hybridization Chain Reaction"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021390578534912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"C-terminal peptide of preproorexin enhances brain-derived neurotrophic factor expression in rat cerebrocortical cells and recognition memory in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021390757812992","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A case of monozygotic twins with hereditary spastic paraplegia type 4 and epilepsy, of whom only one developed narcolepsy type 1"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021391857842944","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Face validation and pharmacologic analysis of Sik3 mutant mouse as a possible model of idiopathic hypersomnia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360022305565603200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton"}]},{"@id":"https://cir.nii.ac.jp/crid/1360025430187246336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Modulation of respiration and hypothalamus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360025430646033152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Orexin/hypocretin receptor 2 signaling in MCH neurons regulates REM sleep and insulin sensitivity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283690455017600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Decreased Intake of Sucrose Solutions in Orexin Knockout Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283690845200256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Hypothalamic Orexin Stimulates Feeding-Associated Glucose Utilization in Skeletal Muscle via Sympathetic Nervous System"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691020582528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Interaction between orexin A and bone morphogenetic protein system on progesterone biosynthesis by rat granulosa cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691071189888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Concurrent and robust regulation of feeding behaviors and metabolism by orexin neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691072221312","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Opioid systems in the lateral hypothalamus regulate feeding behavior through orexin and GABA neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691075939840","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The analgesic effect of orexin-A in a murine model of chemotherapy-induced neuropathic pain"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691094618752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Heating and eating: Brown adipose tissue thermogenesis precedes food ingestion as part of the ultradian basic rest–activity cycle in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691146017920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691641646848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Synthesis and Evaluation of Novel Radioligands for Positron Emission Tomography Imaging of the Orexin-2 Receptor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691836498816","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Optogenetic activation of serotonergic terminals facilitates GABAergic inhibitory input to orexin/hypocretin neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693412051072","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"RETRACTION: Orexin-A Suppresses Postischemic Glucose Intolerance and Neuronal Damage through Hypothalamic Brain-Derived Neurotrophic Factor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706860869888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Role of Orexin/Hypocretin in the Central Nervous System and Peripheral Tissues"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706968852096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"N-acetylmannosamine improves sleep–wake quality in middle-aged mice: Relevance to autonomic nervous function"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706977042944","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Identification of the endogenous cysteine-rich peptide trissin, a ligand for an orphan G protein-coupled receptor in Drosophila"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707001075456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Ghrelin acts centrally to induce an antinociceptive action during colonic distension through the orexinergic, dopaminergic and opioid systems in conscious rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707043726592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Homeostatic Force of Ghrelin"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707168393344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The expression of orexigenic and anorexigenic factors in middle‐aged female rats that had been subjected to prenatal undernutrition"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707277515776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Adenosine A1 receptors mediate the intracisternal injection of orexin-induced antinociceptive action against colonic distension in conscious rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707291665792","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Levodopa acts centrally to induce an antinociceptive action against colonic distension through activation of D2 dopamine receptors and the orexinergic system in the brain in conscious rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707375393792","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Inhibition of opioid systems in the hypothalamus as well as the mesolimbic area suppresses feeding behavior of mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707408402560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Central administration of chicken growth hormone-releasing hormone decreases food intake in chicks"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707426976128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Challenges in the development of therapeutics for narcolepsy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707455113472","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Intermittent but not sustained hypoxia activates orexin-containing neurons in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707455161088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The role of the hypothalamus in modulation of respiration"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707537219840","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Orexin A enhances locomotor activity and induces anxiogenic-like action in the goldfish, Carassius auratus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708531747200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"O-Acyl isopeptide method: efficient synthesis of isopeptide segment and application to racemization-free segment condensation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285709292622592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neural circuit for psychological stress-induced hyperthermia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710788312192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Measurement of cerebrospinal fluid orexin‐A (hypocretin‐1) by enzyme‐linked immunosorbent assay: A comparison with radioimmunoassay"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285714424484352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Orexin Receptor Blockade-Induced Sleep Preserves the Ability to Wake in the Presence of Threat in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360287144531966336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Dual orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617480058624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Hunger Potentiates the Habenular Winner Pathway for Social Conflict by Orexin-Promoted Biased Alternative Splicing of the AMPA Receptor Gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617537165824","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Impacts of Age and Sex in a Mouse Model of Childhood Narcolepsy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643694459008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643719097856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Efferent and Afferent Connections of Neuropeptide Y Neurons in the Nucleus Accumbens of Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643846010496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Synthesis and biological evaluation of novel 18F-labeled phenylbenzofuran-2-carboxamide derivative for detection of orexin 1 receptor in the brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298336547008000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A rare genetic variant in the cleavage site of prepro-orexin is associated with idiopathic hypersomnia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298754804708480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Dual orexin receptor antagonist drug suvorexant can help in amelioration of predictable chronic mild stress-induced hyperalgesia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302474811048192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Interaction modes of human orexin 2 receptor with selective and nonselective antagonists studied by NMR spectroscopy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302864793408256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Association between idiopathic hypersomnia and a genetic variant in the <scp><i>PER3</i></scp> gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302865534626048","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Peripheral vs. core body temperature as hypocretin/orexin neurons degenerate: Exercise mitigates increased heat loss"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302865546390784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Narcolepsy type I-associated DNA methylation and gene expression changes in the human leukocyte antigen region"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302866847488000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Age-Related Changes in Cerebrospinal Fluid Dynamics in the Pathogenesis of Chronic Hydrocephalus in Adults"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306905173002752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neuropeptidergic Input from the Lateral Hypothalamus to the Suprachiasmatic Nucleus Alters the Circadian Period in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306905611865856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Rikkunshito improves anorexia through ghrelin‐ and orexin‐dependent activation of the brain hypothalamus and mesolimbic dopaminergic pathway in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165279852672","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Endogenous orexin-A in the brain mediates 2-deoxy-d-glucose-induced stimulation of gastric motility in freely moving conscious rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165775140096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Long-lasting silencing of orexin/hypocretin neurons using archaerhodopsin induces slow-wave sleep in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166561555712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166561618560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166812302720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The integrative role of orexin/hypocretin neurons in nociceptive perception and analgesic regulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168287630336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mechanistic relationship between the vagal afferent pathway, central nervous system and peripheral organs in appetite regulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565169377621120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neurotensin Co-Expressed in Orexin-Producing Neurons in the Lateral Hypothalamus Plays an Important Role in Regulation of Sleep/Wakefulness States"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565169625420160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Differential Roles of Orexin Receptor-1 and -2 in the Regulation of Non-REM and REM Sleep"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565170746742144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Orexin 2 receptor as a potential target for immunotoxin and antibody-drug conjugate cancer therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567180090040448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Similar changes of hypothalamic feeding‐regulating peptides mRNAs and plasma leptin levels in PTHrP‐, LIF‐secreting tumors‐induced cachectic rats and adjuvant arthritic rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567180159216768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A functional variation in the hypocretin neuropeptide precursor gene may be associated with obstructive sleep apnea syndrome in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181977729024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Orexinergic fibers are in contact with Kölliker-Fuse nucleus neurons projecting to the respiration-related nuclei in the medulla oblongata and spinal cord of the rat"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182256784000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Involvement of orexin in lipid accumulation in the liver"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182357775744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Hypothalamic orexin prevents hepatic insulin resistance induced by social defeat stress in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182385093120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Central orexin inhibits reflex swallowing elicited by the superior laryngeal nerve via caudal brainstem in the rat"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182431823104","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Orexin-B antagonized respiratory depression induced by sevoflurane, propofol, and remifentanil in isolated brainstem-spinal cords of neonatal rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183917760512","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Continuous intrathecal orexin delivery inhibits cataplexy in a murine model of narcolepsy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567186280576640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Reduced brown adipose tissue thermogenesis during environmental interactions in transgenic rats with ataxin-3-mediated ablation of hypothalamic orexin neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567186790919424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567187450116352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"RNA Interference of Gonadotropin-Inhibitory Hormone Gene Induces Arousal in Songbirds"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567187502662016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Meta-Analysis of Melanin-Concentrating Hormone Signaling-Deficient Mice on Behavioral and Metabolic Phenotypes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567187523120896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Monitoring β-arrestin recruitment via β-lactamase enzyme fragment complementation: purification of peptide E as a low-affinity ligand for mammalian bombesin receptors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567187530464512","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Polysomnographic Assessment of Sleep Comorbidities in Drug-Naïve Narcolepsy-Spectrum Disorders—A Japanese Cross-Sectional Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567187889187584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Changes in mRNA expression of arcuate nucleus appetite-regulating peptides during lactation in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567189406293248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Sex differences in feeding behavior in rats: the relationship with neuronal activation in the hypothalamus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567189406762496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neuropeptide Y-Induced Orexigenic Action Is Attenuated by the Orexin Receptor Antagonist in Bullfrog Larvae"}]},{"@id":"https://cir.nii.ac.jp/crid/1360568464771627136","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"OX<sub>2</sub> receptors mediate the inhibitory effects of orexin‐A on potassium chloride‐induced increases in intracellular calcium ion levels in neurons derived from rat dorsal root ganglion in a chronic pain model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360568693353527552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neurophysiology and Treatment of Disorders of Consciousness Induced by Traumatic Brain Injury: Orexin Signaling as a Potential Therapeutic Target"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118692677248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in d-nor-nalfurafine derivatives"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118778097920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<i>In vivo</i>\n                    microdialysis reveals that blockade of accumbal orexin OX\n                    <sub>2</sub>\n                    but not OX\n                    <sub>1</sub>\n                    receptors enhances dopamine efflux in the nucleus accumbens of freely moving rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580229780205952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Design and synthesis of novel orexin 2 receptor agonists with a 1,3,5‑trioxazatriquinane skeleton"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232160779392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neurosecretory Protein GL Promotes Normotopic Fat Accumulation in Male ICR Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232395508352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Bidirectional relationship between sleep and depression"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584339776225536","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Structural and Computational Insights into Dynamics and Intermediate States of Orexin 2 Receptor Signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584340527288576","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Analgesic effect of linalool odor on oral ulcerative mucositis-induced pain in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584340528761344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The opposite roles of orexin neurons in pain and itch neural processing"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588380142543360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Orexin receptor antagonist increases fat oxidation and suppresses protein catabolism during sleep in humans"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640429554176","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Inhibition of ghrelin-induced feeding in rats by pretreatment with a novel dual orexin receptor antagonist"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640672060032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Orexin System in Teleost Fish"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640753380480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Identification of a cDNA encoding a novel small secretory protein, neurosecretory protein GL, in the chicken hypothalamic infundibulum"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641029339776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neuroendocrine control of feeding behavior and psychomotor activity by neuropeptideY in fish"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846642064669184","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846642705535104","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Water deprivation induces appetite and alters metabolic strategy in\n            <i>Notomys alexis</i>\n            : unique mechanisms for water production in the desert"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846645617163648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Orexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846646122324480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Influence of Inhibitory Serotonergic Inputs to Orexin/Hypocretin Neurons on the Diurnal Rhythm of Sleep and Wakefulness"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656475444736","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Anorexia in human and experimental animal models: physiological aspects related to neuropeptides"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656871058048","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Localization of orexin B and orexin-2 receptor in the rat epididymis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656931368320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Involvement of the orexin system in sympathetic nerve regulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656931924992","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"NERP-2 regulates gastric acid secretion and gastric emptying via the orexin pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656945803904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656954532864","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Orexin as a modulator of fear-related behavior: Hypothalamic control of noradrenaline circuit"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657245169536","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Relationship between the fluorescence intensity of rhodamine-labeled orexin A and the calcium responses in cortical neurons: An in vivo two-photon calcium imaging study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657322366464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Involvement of the dopaminergic system in the central orexin-induced antinociceptive action against colonic distension in conscious rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657327543296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Orexin facilitates GABAergic IPSCs via postsynaptic OX1 receptors coupling to the intracellular PKC signalling cascade in the rat cerebral cortex"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657356169472","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Orexin A enhances food intake in bullfrog larvae"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658910154624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Epigenetic Switching by the Metabolism-sensing Factors in the Generation of Orexin Neurons from Mouse Embryonic Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658911757056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Orexin/Hypocretin Activates mTOR Complex 1 (mTORC1) via an Erk/Akt-independent and Calcium-stimulated Lysosome v-ATPase Pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848659811765632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848660552604800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Intra-ventral tegmental area or intracerebroventricular orexin-A increases the intra-cranial self-stimulation threshold via activation of the corticotropin-releasing factor system in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848662476120064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Hepatic Branch Vagus Nerve Plays a Critical Role in the Recovery of Post-Ischemic Glucose Intolerance and Mediates a Neuroprotective Effect by Hypothalamic Orexin-A"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848664384000896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Serotonergic Input to Orexin Neurons Plays a Role in Maintaining Wakefulness and REM Sleep Architecture"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567490102144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Animal models of narcolepsy and the hypocretin/orexin system: Past, present, and future"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567497292800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Early detection of Niemann-pick disease type C with cataplexy and orexin levels: continuous observation with and without Miglustat"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593763897984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Characteristic structural difference between inactive and active states of orexin 2 receptor determined using molecular dynamics simulations"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593764475264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Molecular Dynamics Simulations for the Determination of the Characteristic Structural Differences between Inactive and Active States of Wild Type and Mutants of the Orexin2 Receptor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861295378650880","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pilot Study of Lemborexant for Insomnia in Cancer Patients with Delirium"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861704760420608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Dual orexin receptor blocker suvorexant attenuates hypercapnic ventilatory augmentation in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865814745075328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Brain Neuropeptides, Neuroinflammation, and Irritable Bowel Syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865814751547776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Safety and real-world efficacy of lemborexant in the treatment of comorbid insomnia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865814752949120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Deficiency of orexin signaling during sleep is involved in abnormal REM sleep architecture in narcolepsy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865815688557184","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Orexinergic neurons contribute to autonomic cardiovascular regulation for locomotor exercise"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865815693509760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nicotine suppresses central post-stroke pain via facilitation of descending noradrenergic neuron through activation of orexinergic neuron"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865816783293440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The present and future of synthetic orexin receptor agonists"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865816800474240","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Development of Novel <sup>11</sup>C-Labeled Selective Orexin-2 Receptor Radioligands for Positron Emission Tomography Imaging"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865816801047040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Orexin neurons play contrasting roles in itch and pain neural processing via projecting to the periaqueductal gray"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869854346203392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The neurotensin receptor 1 agonist <scp>PD</scp>149163 alleviates visceral hypersensitivity and colonic hyperpermeability in rat irritable bowel syndrome model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869855136378368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Structure-Affinity-Pharmacokinetics Relationships of Novel <sup>18</sup>F-Labeled 1,4-Diazepane Derivatives for Orexin 1 Receptor Imaging"}]},{"@id":"https://cir.nii.ac.jp/crid/1361412891701525504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Involvement of descending pain control system regulated by orexin receptor signaling in the induction of central post-stroke pain in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361694366551202176","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Synthesis and biological evaluation of F-18 labeled tetrahydroisoquinoline derivatives targeting orexin 1 receptor"}]},{"@id":"https://cir.nii.ac.jp/crid/1361694368943274112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Leptin promotes the fat preference associated with low-temperature acclimation in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361975843346026880","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Synthesis and characterization of a novel <sup>18</sup>F-labeled 2,5-diarylnicotinamide derivative targeting orexin 2 receptor"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320817458432","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Central oxytocin signaling mediates the central orexin-induced visceral antinociception through the opioid system in conscious rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204271663872","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"ストレスと脳　　３　　ストレスが変える視床下部の遺伝子"},{"@language":"en","@value":"Stress-induced gene expression in the hypothalamus"},{"@value":"ストレスが変える視床下部の遺伝子"},{"@language":"ja-Kana","@value":"ストレス ガ カエル シショウカブ ノ イデンシ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204271729920","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"ＧＰＣＲ研究の新しい流れ　　４　　オレキシンの発見"},{"@language":"en","@value":"Discovery of orexin"},{"@value":"オレキシンの発見"},{"@language":"ja-Kana","@value":"オレキシン ノ ハッケン"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204271734784","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"ＧＰＣＲ研究の新しい流れ　　５　　ニューロペプチドＷおよびニューロペプチドＢの発見"},{"@language":"en","@value":"Discovery of neuropeptide W and neuropeptide B"},{"@value":"ニューロペプチドWおよびニューロペプチドBの発見"},{"@language":"ja-Kana","@value":"ニューロペプチド W オヨビ ニューロペプチド B ノ ハッケン"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204272626560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"治療薬シリーズ（１）うつ病　　１）オーファンＧＰＣＲとうつ病"},{"@language":"en","@value":"Finding a novel target for depression through the orphan receptor strategy"},{"@value":"オーファンGPCRとうつ病"},{"@language":"ja-Kana","@value":"オーファン GPCR ト ウツビョウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204274145024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The development of post-ischemic glucose intolerance induced by cerebral neuronal damage and the involvement of  the communication system between the brain and peripheral tissues"},{"@language":"ja","@value":"『脳梗塞治療における新たな可能性を探る』　脳血管障害誘導性耐糖能異常の発現における中枢－末梢臓器間連関機構の関与"},{"@language":"ja-Kana","@value":"ノウ コウソク チリョウ ニ オケル アラタ ナ カノウセイ オ サグル : ノウ ケッカン ショウガイ ユウドウセイ タイトウノウ イジョウ ノ ハツゲン ニ オケル チュウスウ-マッショウ ゾウキ カン レンカン キコウ ノ カンヨ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204274805376","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"新規不眠症治療薬，スボレキサント（ベルソムラ錠<sup>®</sup>15 mg，20 mg）の薬理学的特徴及びその臨床試験成績"},{"@language":"en","@value":"Preclinical and clinical results of dual orexin receptor antagonist, suvorexant (BELSOMRA<sup>®</sup>), a novel therapeutic agent for insomnia"},{"@value":"新薬紹介総説 新規不眠症治療薬,スボレキサント(ベルソムラ錠15mg,20mg)の薬理学的特徴及びその臨床試験成績"},{"@language":"ja-Kana","@value":"シンヤク ショウカイ ソウセツ シンキ フミンショウ チリョウヤク,スボレキサント(ベルソムラジョウ 15mg,20mg)ノ ヤクリガクテキ トクチョウ オヨビ ソノ リンショウ シケン セイセキ"},{"@value":"Preclinical and clinical results of dual orexin receptor antagonist, suvorexant (BELSOMRA(®)), a novel therapeutic agent for insomnia"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204274812032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"脳梗塞に伴う糖代謝異常と中枢－末梢臓器間連関機序の関与"},{"@language":"en","@value":"Involvement of communication system between brain and peripheral tissues on the development of post-ischemic glucose intolerance induced by cerebral neuronal damage"},{"@language":"ja-Kana","@value":"ノウ コウソク ニ トモナウ トウ タイシャ イジョウ ト チュウスウ-マッショウ ゾウキ カン レンカン キジョ ノ カンヨ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204287414144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Orphan G Protein-Coupled Receptors and Beyond."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204331804160","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"オレキシンニューロンの多様性—形態学的解析にもとづいて—"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204350781312","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"Ｏｒｅｘｉｎ　ｋｎｏｃｋｏｕｔ　ｍｉｃｅは蔗糖溶液摂取量が減少する"},{"@language":"en","@value":"Decreased sucrose intake in orexin knockout mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204352319488","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Regulation of Appetite and Energy Metabolism by Neuropeptides in Brain"},{"@value":"神経ペプチドによる食欲・エネルギー代謝調節"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204353408256","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Food intake and brain substances"},{"@language":"ja","@value":"おいしさと食行動における脳内物質の役割"},{"@language":"ja-Kana","@value":"オイシサ ト ショク コウドウ ニ オケル ノウナイ ブッシツ ノ ヤクワリ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204366583680","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Evaluating Psychobiologic Effects Induced by Spice through Salivary Biomarkers"},{"@language":"ja","@value":"香辛料により引き起こされる生理反応の唾液バイオマーカーを用いた評価"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204553220608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A Six Year-Old Case of Narcolepsy"},{"@value":"６歳発症のナルコレプシーの１男児例"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204862175616","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Distribution and Neuronal Networks of Novel GPCR Ligands in Feeding Regulation"},{"@value":"Distribution and Neuronal Networks of Novel GPCR Ligands in Feeding Regulation(<SPECIAL ISSUE>Tokyo Satellite Symposium \"Contribution of Histochemistry in Basic Science and Clinical Medicine\")"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204890852096","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"ストレスに関連する視床下部の新しい神経ペプチド遺伝子の発見"},{"@language":"en","@value":"Discovery of Novel Hypothalamic Neuropeptides Related to Stress"},{"@language":"ja-Kana","@value":"ストレス ニ カンレン スル シショウカブ ノ アタラシイ シンケイ ペプチド イデンシ ノ ハッケン"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205037485824","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A marked decrease of orexin in the cerebrospinal fluid in a patient with myotonic dystrophy type 1 showing an excessive daytime sleepiness"},{"@language":"ja","@value":"髄液オレキシンが異常低値で重度の過眠症を呈した筋強直性ジストロフィーの１例"},{"@language":"ja-Kana","@value":"ズイエキ オレキシン ガ イジョウ テイチ デ ジュウド ノ カミンショウ オ テイシタ キン キョウチョクセイ ジストロフィー ノ 1レイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205045636864","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Role of orexin receptor subtypes in the inhibitory effects of orexin-A on potassium chloride-induced increases in intracellular calcium ion levels in neurons derived from dorsal root ganglion of carrageenan-treated rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205094931840","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Steroid Hormones, their Receptors and Neuroendocrine System"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205175585152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Orexin Receptor Type-1 Couples Exclusively to Pertussis Toxin-Insensitive G-Proteins, While Orexin Receptor Type-2 Couples to Both Pertussis Toxin-Sensitive and -Insensitive G-Proteins"},{"@value":"Orexin Receptors and G-Protein Coupling: Evidence for Another \"Promiscuous\" Seven Transmembrane Domain Receptor"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205179028608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Nucleus Accumbens and Dopamine-Mediated Turning Behavior of the Rat: Role of Accumbal Non-dopaminergic Receptors"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205181646592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Ischemic Stroke and Glucose Intolerance: a Review of the Evidence and Exploration of Novel Therapeutic Targets"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205205748608","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Hypoleptinemia Associated with Hypermetabolism, Low Adiposity Body Composition and Overeating Behavior in Children with Jaundiced Biliary Atresia"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205232683648","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Neuronal Network for the Regulation System of Stress, Feeding and Sexual Behavior"},{"@language":"ja","@value":"ストレス，摂食，性の制御機構に関する中枢神経ネットワーク"},{"@value":"基礎研究から学ぶ ストレス,摂食,性の制御機構に関する中枢神経ネットワーク"},{"@language":"ja-Kana","@value":"キソ ケンキュウ カラ マナブ ストレス セッショク セイ ノ セイギョ キコウ ニ カンスル チュウスウ シンケイ ネットワーク"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205252291072","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Lack of Ghrelin Secretion in Response to Fasting in Cholecystokinin-A (-1), -B (-2) Receptor-Deficient Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205291581056","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"神経ペプチドによるキンギョの摂食制御機構：摂食制御システムの進化的変遷過程の解明を目指して"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205292051712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"ニューロメジンＳとその多様な機能"},{"@value":"新しい内分泌現象 ニューロメジンSとその多様な機能"},{"@language":"ja-Kana","@value":"アタラシイ ナイブンピツ ゲンショウ ニューロメジン S ト ソノ タヨウ ナ キノウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206299041280","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Hypothalamic Neuropeptides and Appetite Response in Anorexia-Cachexia Animal"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206431210752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Clorgyline Inhibits Orexin-A-Induced Arousal in Layer-Type Chicks"},{"@value":"Physiology: Clorgyline inhibits orexin-A-induced arousal in layer-type chicks"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206443350272","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"医学と医療の最前線　　オレキシン神経系とナルコレプシー"},{"@language":"ja-Kana","@value":"イガク ト イリョウ ノ サイゼンセン オレキシン シンケイケイ ト ナルコレプシー"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206478403584","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Characterization of the Promoter of the Mouse Preproorexin Gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1390002184858743040","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Obesity-related hypertension and enhanced plasma orexin-A level are attenuated by the consumption of thiamine water in diabetic rats under cerebral oxidative stress conditions"}]},{"@id":"https://cir.nii.ac.jp/crid/1390005506388178048","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of Histamine and Related Compounds on the Central Nervous System"},{"@language":"ja","@value":"ヒスタミン並びに関連化合物の中枢神経機能に対する効果"},{"@language":"ja-Kana","@value":"ヒスタミン ナラビニ カンレン カゴウブツ ノ チュウスウ シンケイ キノウ ニ タイスル コウカ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390017732461823872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Hypothalamic Orexinergic Neurons Projecting to the Mesencephalic Locomotor Region Are Activated by Voluntary Wheel Running Exercise in Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1390020840082134016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Interaction Modes of Human Orexin 2 Receptor with Selective and Nonselective Antagonists Studied by NMR Spectroscopy"},{"@language":"ja","@value":"NMR分光法を用いたオレキシン2受容体と選択的／非選択的拮抗薬との相互作用様式の解析"},{"@language":"ja-Kana","@value":"NMR ブンコウホウ オ モチイタ オレキシン 2 ジュヨウタイ ト センタクテキ/ヒセンタクテキ キッコウヤク ト ノ ソウゴ サヨウ ヨウシキ ノ カイセキ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679220514176","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Neuropeptide Y mediates orexin A-mediated suppression of pulsatile gonadotropin-releasing hormone secretion in ovariectomized rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679247133824","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Roles of biologically active peptide in regulation of feeding behavior and energy homeostasis."},{"@language":"ja","@value":"薬理学のＱＯＬへの貢献　　５　　摂食関連ペプチドの生理"},{"@value":"摂食関連ペプチドの生理"},{"@language":"ja-Kana","@value":"セッショク カンレン ペプチド ノ セイリ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679250202624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Animal models of sleep research"},{"@language":"ja","@value":"睡眠研究と動物モデル"},{"@language":"ja-Kana","@value":"スイミン ケンキュウ ト ドウブツ モデル"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679253101440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Apelin-APJ system: from discovery to therapeutic target"},{"@language":"ja","@value":"アペリン–APJシステムの機能と病態生理"},{"@language":"ja-Kana","@value":"アペリン – APJ システム ノ キノウ ト ビョウタイ セイリ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679461334912","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Plasma Levels of Orexin-A and Leptin in Obese Children"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679848491648","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Possible Mechanism of Secondary Narcolepsy with a Long Sleep Time Following Surgery for Craniopharyngioma"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679856793472","@type":"Article","resourceType":"記事(article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"薬物相互作用 （38―新規睡眠薬 : ラメルテオン, スボレキサントの相互作用）"},{"@language":"en","@value":"Drug interaction (38. Combination with novel hypnotic drugs : ramelteon and suvorexant)"},{"@value":"ニュース&ビュー ためになる薬の話 薬物相互作用(38)新規睡眠薬 : ラメルテオン,スボレキサントの相互作用"},{"@language":"ja-Kana","@value":"ニュース&ビュー タメニ ナル クスリ ノ ハナシ ヤクブツ ソウゴ サヨウ(38)シンキ スイミンヤク : ラメルテオン,スボレキサント ノ ソウゴ サヨウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679878833024","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Stimulation of phagocytosis in mouse peritoneal macrophages by orexin-B and orexin-A"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680013623680","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"過眠を主症状とし，脳幹，視床下部のposterior reversible encephalopathy syndromeを呈したuremic encephalopathyの1例"},{"@language":"en","@value":"Posterior reversible encephalopathy syndrome of the midbrain and hypothalamus — a case report of uremic encephalopathy presenting with hypersomnia —"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680157482368","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Roles of Hypothalamic Subgroup Histamine and Orexin Neurons on Behavioral Responses to Sleep Deprivation Induced by the Treadmill Method in Adolescent Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680184390784","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Regulation of Energy Balance in Birds by the Neuroendocrine Hypothalamus"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680188808960","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"<b>Orexin-A Inhibits the High Potassium-Induced Increase in Intracellular Calcium Levels in Cultured Dorsal Root Ganglions Neurons from Carrageenan-Treated Rats </b>"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680268287744","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"魚類における体色調節ホルモンの脳内ネットワーク"},{"@value":"博士論文レビュー 魚類における体色調節ホルモンの脳内ネットワーク"},{"@language":"ja-Kana","@value":"ハクシ ロンブン レビュー ギョルイ ニ オケル タイショク チョウセツ ホルモン ノ ノウナイ ネットワーク"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680268291584","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"オーファンＧタンパク質共役型受容体研究の進歩"},{"@language":"ja-Kana","@value":"オーファン G タンパクシツ キョウヤクガタ ジュヨウタイ ケンキュウ ノ シンポ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681104414208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"脳虚血性耐糖能異常に起因する神経障害発現に対するorexin-Aの中枢末梢臓器間連関機構を介した役割"},{"@language":"en","@value":"Role of Orexin-A-mediated Communication System between Brain and Peripheral Tissues on the Development of Post-ischemic Glucose Intolerance-induced Neuronal Damage"},{"@language":"ja-Kana","@value":"ノウキョケツセイ タイトウノウ イジョウ ニ キイン スル シンケイ ショウガイ ハツゲン ニ タイスル orexin-A ノ チュウスウ マッショウ ゾウキ カン レンカン キコウ オ カイシタ ヤクワリ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681275771264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Reduced Carnitine Level Causes Death from Hypoglycemia: Possible Involvement of Suppression of Hypothalamic Orexin Expression During Weaning Period"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681407055104","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Immunohistochemical Changes in Orexigenic and Anorexigenic Neuropeptides in the Rat Hypothalamus after Capsaicin Administration"},{"@value":"Anatomy: Immunohistochemical changes in orexigenic and anorexigenic neuropeptides in the rat hypothalamus after capsaicin administration"}]},{"@id":"https://cir.nii.ac.jp/crid/1390283659865592832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Multi-dimensional role of the parabrachial nucleus in regulating pain-related affective disturbances in trigeminal neuropathic pain"}]},{"@id":"https://cir.nii.ac.jp/crid/1390287297544302464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Preclinical and clinical efficacy of orexin receptor antagonist Lemborexant (Dayvigo<sup>®</sup>) on insomnia patients"},{"@language":"ja","@value":"新規オレキシン受容体拮抗薬レンボレキサント（デエビゴ錠<sup>®</sup> 2.5 mg，5 mg，10 mg）の薬理効果と不眠症患者における臨床的有用性"},{"@value":"新規オレキシン受容体拮抗薬レンボレキサント(デエビゴ錠2.5mg, 5mg, 10mg)の薬理効果と不眠症患者における臨床的有用性 : 新薬紹介総説"},{"@language":"ja-Kana","@value":"シンキ オレキシン ジュヨウタイ キッコウヤク レンボレキサント(デエビゴジョウ 2.5mg, 5mg, 10mg)ノ ヤクリ コウカ ト フミンショウ カンジャ ニ オケル リンショウテキ ユウヨウセイ : シンヤク ショウカイ ソウセツ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390290537431847296","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Focus on orexin-A in obese diabetes rats: upregulation of orexin-A receptor in the diabetic brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1390564238008926848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"視床下部オレキシンニューロンの選択的変性に関与する要因"},{"@language":"en","@value":"Cellular mechanisms involved in induction of selective degeneration of orexin neurons in the hypothalamus"},{"@language":"ja-Kana","@value":"シショウカブ オレキシンニューロン ノ センタクテキ ヘンセイ ニ カンヨ スル ヨウイン"}]},{"@id":"https://cir.nii.ac.jp/crid/1390566775145726336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Orexins modulate membrane excitability in rat trigeminal motoneurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1390576745204709888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Synthesis and Characterization of Novel Radioiodinated Triazole-Pyrolidine Derivative to Detect Orexin 2 Receptor in the Brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1390587450507448704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"MR Imaging Indices for Brain Interstitial Fluid Dynamics and the Effects of Orexin Antagonists on Sleep"}]},{"@id":"https://cir.nii.ac.jp/crid/1390845702317056896","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cellular mechanisms for antinociception produced by hypothalamus–derived neuropeptides in the rat spinal superficial dorsal horn —oxytocin and orexins actions"},{"@language":"ja","@value":"視床下部由来の神経ペプチドによるラット脊髄後角浅層での鎮痛の機序 ─オキシトシンとオレキシンの作用"}]},{"@id":"https://cir.nii.ac.jp/crid/1390846609792406912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Forward genetic approach for behavioral neuroscience using animal models"}]},{"@id":"https://cir.nii.ac.jp/crid/1390848647544280576","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Control of Sleep/Wakefulness by Using Optogenetics for Study of Sleep Disease"},{"@language":"ja","@value":"光による睡眠覚醒の制御と疾患研究"}]},{"@id":"https://cir.nii.ac.jp/crid/1520010380824092800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Clinical characteristics of symptomatic narcolepsy or hypersomnia : an analysis of 182 consecutive cases with neurological disorders associated with hypersomnolence"}]},{"@id":"https://cir.nii.ac.jp/crid/1520300152481055104","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Expression of mRNAs Encoding Hypothalamic Small Proteins, Neurosecretory Protein GL and Neurosecretory Protein GM, in the Japanese Quail, Coturnix japonica"}]},{"@id":"https://cir.nii.ac.jp/crid/1520853833171243520","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"視床下部弓状核ニューロン活動に対する摂食調節ペプチドの作用"},{"@language":"ja-Kana","@value":"シショウカブ キュウジョウカク ニューロン カツドウ ニ タイスル セッショク チョウセツ ペプチド ノ サヨウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1523951029846260096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Food Deprivation Increases the Expression of the Prepro-orexin Gene in the Hypothalamus of the Barfin Flounder, Verasper moseri"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980074995345792","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"オレキシン, ニューロメジンU, GALPと視床下部-下垂体系"},{"@language":"en","@value":"Orexins, neuromedin U, GALP and hypothalamo-neurohypophyseal system"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950399591983872","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"睡眠呼吸障害患者における睡眠障害と血清オレキシンA濃度の関係"},{"@language":"en","@value":"Relationship between Sleep Disturbance and Serum Orexin-A in Patient with Sleep Disordered Breathing"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950399832314880","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"走運動時のストレス反応とオレキシン神経の活性化"},{"@language":"en","@value":"Running-induced stress response and activation of orexin neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/2051714792004546560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Messenger RNA expression profile of sleep-related genes in peripheral blood cells in patients with chronic kidney disease"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/s0092-8674(00)80949-6"},{"@type":"CIA","@value":"30010682494"},{"@type":"OPENAIRE","@value":"doi_dedup___::320836d1dc2ad7cc540df80075335a66"},{"@type":"CROSSREF","@value":"10.1007/s40263-012-0036-8_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1210/en.2017-00064_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.5665/sleep.5446_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1002/cne.24261_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1038/s41598-019-39063-y_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1038/srep01518_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1113/jphysiol.2013.261271_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1254/jjp.90.101_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.cmet.2018.02.008_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.neulet.2019.134592_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.neures.2017.03.015_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.resp.2018.07.003_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1021/acs.jmedchem.5b00988_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.neures.2017.08.001_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.neulet.2015.08.013_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1507/endocrj.k07-044_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1507/endocrj.kr-111_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.peptides.2019.01.002_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.2169/internalmedicine.51.6101_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1254/fpj.122.236_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1254/fpj.139.198_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1254/fpj.129.413_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.5692/clinicalneurol.49.437_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.5983/nl2008jsce.34.24_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1254/fpj.148.46_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.job.2018.07.001_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.2108/zsj.29.43_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.physbeh.2014.03.009_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.resp.2014.10.013_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.bcp.2020.114262_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.npep.2021.102129_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.3390/ijms22094553_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.3987/com-20-s(k)63_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1007/s11033-021-06198-z_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1038/s41598-020-76329-2_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.2131/fts.8.235_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.npep.2021.102188_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.str.2022.11.001_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.physbeh.2018.10.007_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.ejphar.2023.176306_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.str.2023.12.008_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1111/jsr.14102_references_DOI_QXFCivqTnR7akGL1YMGnOxHzzEJ"},{"@type":"CROSSREF","@value":"10.1016/j.ejphar.2023.175877_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.2463/mrms.mp.2024-0176_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/bs.vh.2024.06.006_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.celrep.2025.115277_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1007/s12031-010-9475-1_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1038/srep36039_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1038/srep37129_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1124/jpet.112.199604_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1271/bbb.60100_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1007/s10157-015-1150-y_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1007/s41105-018-0186-2_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.ijdevneu.2015.12.002_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1039/b903624e_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1080/23328940.2015.1070944_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1111/pcn.12780_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.3389/fnbeh.2018.00327_references_DOI_QXFCivqTnR7akGL1YMGnOxHzzEJ"},{"@type":"CROSSREF","@value":"10.1016/j.npep.2013.02.002_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.7554/elife.54275_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.npep.2016.12.007_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.jns.2016.01.031_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1292/jvms.001337_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.physbeh.2014.11.043_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1618/jhes.5.41_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.2334/josnusd.16-0759_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1254/fpj.130.19_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.bmcl.2019.04.044_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1254/jphs.93.126_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1254/fpj.126.179_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.2220/biomedres.25.249_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.2184/lsj.41.2_92_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.npep.2012.09.006_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.bmcl.2017.12.069_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2011.09.018_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/b978-0-12-381272-8.00002-7_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2015.03.157_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.5983/nl2008jsce.34.10_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.2334/josnusd.19-0432_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.celrep.2020.107790_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.3389/fnins.2021.644757_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.bmcl.2022.128530_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.bmcl.2022.128555_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.3389/fnana.2021.741868_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.bmcl.2021.128098_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1038/s41525-022-00298-w_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1248/cpb.c22-00770_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1523/jneurosci.0073-14.2014_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.brainresbull.2022.07.011_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1021/acs.jmedchem.2c01773_references_DOI_QXFCivqTnR7akGL1YMGnOxHzzEJ"},{"@type":"CROSSREF","@value":"10.1016/j.ejmech.2022.114505_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.33160/yam.2024.02.006_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1111/jsr.14146_references_DOI_QXFCivqTnR7akGL1YMGnOxHzzEJ"},{"@type":"CROSSREF","@value":"10.1016/j.peptides.2023.171002_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1038/s41598-023-37511-4_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.wneu.2023.07.110_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1523/jneurosci.0351-24.2024_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1111/nmo.14900_references_DOI_QXFCivqTnR7akGL1YMGnOxHzzEJ"},{"@type":"CROSSREF","@value":"10.1007/s00535-011-0506-7_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1038/srep29480_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1111/jdi.12492_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0062391_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.3389/fnbeh.2015.00324_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1002/ijc.25535_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1002/lary.23179_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1073/pnas.1722686115_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1080/23328940.2015.1066921_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1152/ajpregu.00260.2014_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1186/s13041-015-0142-x_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0030202_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0099961_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0127445_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0136988_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1530/jme-13-0015_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.3389/fnins.2015.00088_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.3389/fnins.2017.00176_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1002/npr2.12094_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.str.2017.11.005_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.2183/pjab.96.002_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.2174/1381612825666191029101830_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.7554/elife.44927_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1254/fpj.20093_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.bmcl.2019.07.039_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.brainres.2018.02.024_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1292/jvms.10-0358_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1267/ahc.38.189_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1297/cpe.13.47_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.brainres.2016.08.020_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.jsbmb.2018.03.004_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1021/jm400772t_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.5136/lifesupport.25.63_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.7144/sgf.16.85_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.5983/nl2008jsce.35.118_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.7144/sgf.18.70_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.resp.2014.11.003_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.3892/ol.2011.528_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.autneu.2020.102712_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.bmcl.2022.128550_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1111/ejn.15593_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1523/jneurosci.1130-13.2013_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.bmcl.2023.129151_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.3390/ijms23126488_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.neures.2023.04.006_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1089/jpm.2021.0509_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1021/acs.jpcb.4c00730_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.brainresbull.2023.110844_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.peptides.2022.170928_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.3389/fncir.2024.1473403_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.isci.2024.110212_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1007/s12576-016-0517-5_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1038/ncomms10583_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1073/pnas.1700499114_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1098/rspb.2011.2627_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.3390/ph10040079_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.5665/sleep.2972_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1007/s12576-015-0386-3_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1074/jbc.m113.455899_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1074/jbc.m114.600015_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1097/aln.0000000000002161_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1111/j.1460-9568.2011.07808.x_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0095433_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.3389/fnins.2018.00892_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1254/jphs.11r04cr_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.2141/jpsa.42.161_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.bbr.2013.05.021_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.neures.2017.04.017_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1254/jphs.92.259_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2019.04.145_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.2334/josnusd.19-0141_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1272/jnms.72.316_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1272/manms.4.25_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.2170/physiolsci.rp003306_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.physbeh.2011.11.009_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.isci.2019.09.003_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.2152/jmi.58.11_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1254/jphs.10177fp_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.2169/naika.95.748_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1254/fpj.130.23_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1254/fpj.142.4_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1254/fpj.127.190_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1254/jphs.12r02cr_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.5983/nl2001jsce.2001.100_24_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.5983/nl2008jsce.37.124_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.neuroscience.2015.10.002_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.bmcl.2017.07.011_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1254/fpj.148.34_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.orcp.2013.01.005_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.4044/joma.129.53_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.2131/fts.6.383_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1093/sleep/zsaa278_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1186/s13023-020-01531-4_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.3390/ijms21124422_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1254/fpj.152.70_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1007/s12551-021-00862-1_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1021/acs.jpcb.0c10985_references_DOI_QXFCivqTnR7akGL1YMGnOxHzzEJ"},{"@type":"CROSSREF","@value":"10.1523/jneurosci.6506-10.2011_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1159/000350391_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.brainres.2022.148061_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.2108/zs230070_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.2142/biophys.64.263_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1159/000533275_references_DOI_QXFCivqTnR7akGL1YMGnOxHzzEJ"},{"@type":"CROSSREF","@value":"10.1016/j.sleepx.2023.100070_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1073/pnas.2301951120_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1113/jp285791_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.ejphar.2023.175518_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.peptides.2023.171051_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1021/acsmedchemlett.3c00320_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1038/s42003-024-05997-x_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1523/eneuro.0474-23.2024_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1111/nmo.14925_references_DOI_QXFCivqTnR7akGL1YMGnOxHzzEJ"},{"@type":"CROSSREF","@value":"10.1021/acs.jmedchem.4c01090_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1038/s42003-024-07438-1_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.pneurobio.2015.12.002_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.resp.2014.06.006_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.neuropharm.2019.02.012_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.bmc.2019.03.010_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.bmcl.2019.126893_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.neures.2017.03.013_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.jsmc.2017.03.003_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.yhbeh.2014.06.004_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.peptides.2014.07.013_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1080/09168451.2020.1732186_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1248/yakushi.20-00197_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.neures.2012.07.005_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.conb.2017.03.020_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.jphs.2016.01.007_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2017.02.064_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.jphs.2018.09.005_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/b978-0-444-59489-1.00002-1_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.autneu.2014.11.005_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.11154/pain.34.228_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.7144/sgf.18.107_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.acthis.2018.02.011_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1039/c9md00397e_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.ejphar.2020.173029_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1021/acs.jmedchem.6b01418_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/b978-0-12-394623-2.00002-0_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/b978-0-12-394623-2.00018-4_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1248/yakushi.14-00171_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.5466/ijoms.13.94_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.brainres.2014.12.021_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.neuroscience.2016.02.002_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.tips.2011.03.007_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.5692/clinicalneurol.cn-000806_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.brainres.2018.11.032_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2014.02.090_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.neuropharm.2014.06.015_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"},{"@type":"CROSSREF","@value":"10.1016/j.cmet.2009.09.013_references_DOI_xWVUiEM61a30oFXWAbovRyCGRY"}]}