{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699995419103232.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1200/jco.2016.68.7830"}},{"identifier":{"@type":"URI","@value":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2016.68.7830"}}],"dc:title":[{"@value":"Multidisciplinary Approach to Novel Therapies in Cardio-Oncology Research (MANTICORE 101–Breast): A Randomized Trial for the Prevention of Trastuzumab-Associated Cardiotoxicity"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec>\n                    <jats:title>Purpose</jats:title>\n                    <jats:p>The primary toxicity of trastuzumab therapy for human epidermal growth factor receptor 2–overexpressing (HER2-positive) breast cancer is dose-independent cardiac dysfunction. Angiotensin-converting enzyme inhibitors and β-blockers are recommended first-line agents for heart failure. We hypothesized that angiotensin-converting enzyme inhibitors and β-blockers could prevent trastuzumab-related cardiotoxicity.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods</jats:title>\n                    <jats:p>In this double-blinded, placebo-controlled trial, patients with HER2-positive early breast cancer were randomly assigned to receive treatment with perindopril, bisoprolol, or placebo (1:1:1) for the duration of trastuzumab adjuvant therapy. Patients underwent cardiac magnetic resonance imaging at baseline and post–cycle 17 for the determination of left ventricular volumes and left ventricular ejection fraction (LVEF). Cardiotoxicity was evaluated as the change in indexed left ventricular end diastolic volume and LVEF.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results</jats:title>\n                    <jats:p>\n                      Thirty-three patients received perindopril, 31 received bisoprolol, and 30 received placebo. Baseline demographic, cancer, and cardiovascular profiles were similar between groups. Study drugs were well tolerated with no serious adverse events. After 17 cycles of trastuzumab, indexed left ventricular end diastolic volume increased in patients treated with perindopril (+7 ± 14 mL/m\n                      <jats:sup>2</jats:sup>\n                      ), bisoprolol (+8 mL ± 9 mL/m\n                      <jats:sup>2</jats:sup>\n                      ), and placebo (+4 ± 11 mL/m\n                      <jats:sup>2</jats:sup>\n                      ; P = .36). In secondary analyses, trastuzumab-mediated decline in LVEF was attenuated in bisoprolol-treated patients (−1 ± 5%) relative to the perindopril (−3 ± 4%) and placebo (−5 ± 5%) groups ( P = .001). Perindopril and bisoprolol use were independent predictors of maintained LVEF on multivariable analysis.\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion</jats:title>\n                    <jats:p>Perindopril and bisoprolol were well tolerated in patients with HER2-positive early breast cancer who received trastuzumab and protected against cancer therapy–related declines in LVEF; however, trastuzumab-mediated left ventricular remodeling—the primary outcome—was not prevented by these pharmacotherapies.</jats:p>\n                  </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699995419103107","@type":"Researcher","foaf:name":[{"@value":"Edith Pituskin"}],"jpcoar:affiliationName":[{"@value":"Edith Pituskin John R. Mackey, Sheri Koshman, Mark J. Haykowsky, Joseph J. Pagano, Kelvin Chow, Richard B. Thompson, Larissa J. Vos, Sunita Ghosh, Gavin Y. Oudit, Justin A. Ezekowitz, and D. Ian Paterson, University of Alberta, Edmonton, Alberta; and Davinder Jassal and Marshall Pitz, University of Manitoba, Winnipeg, Manitoba, Canada."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995419103104","@type":"Researcher","foaf:name":[{"@value":"John R. Mackey"}],"jpcoar:affiliationName":[{"@value":"Edith Pituskin John R. Mackey, Sheri Koshman, Mark J. Haykowsky, Joseph J. Pagano, Kelvin Chow, Richard B. Thompson, Larissa J. Vos, Sunita Ghosh, Gavin Y. Oudit, Justin A. Ezekowitz, and D. Ian Paterson, University of Alberta, Edmonton, Alberta; and Davinder Jassal and Marshall Pitz, University of Manitoba, Winnipeg, Manitoba, Canada."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995419103108","@type":"Researcher","foaf:name":[{"@value":"Sheri Koshman"}],"jpcoar:affiliationName":[{"@value":"Edith Pituskin John R. Mackey, Sheri Koshman, Mark J. Haykowsky, Joseph J. Pagano, Kelvin Chow, Richard B. Thompson, Larissa J. Vos, Sunita Ghosh, Gavin Y. Oudit, Justin A. Ezekowitz, and D. Ian Paterson, University of Alberta, Edmonton, Alberta; and Davinder Jassal and Marshall Pitz, University of Manitoba, Winnipeg, Manitoba, Canada."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995419103109","@type":"Researcher","foaf:name":[{"@value":"Davinder Jassal"}],"jpcoar:affiliationName":[{"@value":"Edith Pituskin John R. Mackey, Sheri Koshman, Mark J. Haykowsky, Joseph J. Pagano, Kelvin Chow, Richard B. Thompson, Larissa J. Vos, Sunita Ghosh, Gavin Y. Oudit, Justin A. Ezekowitz, and D. Ian Paterson, University of Alberta, Edmonton, Alberta; and Davinder Jassal and Marshall Pitz, University of Manitoba, Winnipeg, Manitoba, Canada."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995419103232","@type":"Researcher","foaf:name":[{"@value":"Marshall Pitz"}],"jpcoar:affiliationName":[{"@value":"Edith Pituskin John R. Mackey, Sheri Koshman, Mark J. Haykowsky, Joseph J. Pagano, Kelvin Chow, Richard B. Thompson, Larissa J. Vos, Sunita Ghosh, Gavin Y. Oudit, Justin A. Ezekowitz, and D. Ian Paterson, University of Alberta, Edmonton, Alberta; and Davinder Jassal and Marshall Pitz, University of Manitoba, Winnipeg, Manitoba, Canada."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995419103106","@type":"Researcher","foaf:name":[{"@value":"Mark J. Haykowsky"}],"jpcoar:affiliationName":[{"@value":"Edith Pituskin John R. Mackey, Sheri Koshman, Mark J. Haykowsky, Joseph J. Pagano, Kelvin Chow, Richard B. Thompson, Larissa J. Vos, Sunita Ghosh, Gavin Y. Oudit, Justin A. Ezekowitz, and D. Ian Paterson, University of Alberta, Edmonton, Alberta; and Davinder Jassal and Marshall Pitz, University of Manitoba, Winnipeg, Manitoba, Canada."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995419103233","@type":"Researcher","foaf:name":[{"@value":"Joseph J. Pagano"}],"jpcoar:affiliationName":[{"@value":"Edith Pituskin John R. Mackey, Sheri Koshman, Mark J. Haykowsky, Joseph J. Pagano, Kelvin Chow, Richard B. Thompson, Larissa J. Vos, Sunita Ghosh, Gavin Y. Oudit, Justin A. Ezekowitz, and D. Ian Paterson, University of Alberta, Edmonton, Alberta; and Davinder Jassal and Marshall Pitz, University of Manitoba, Winnipeg, Manitoba, Canada."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995419103237","@type":"Researcher","foaf:name":[{"@value":"Kelvin Chow"}],"jpcoar:affiliationName":[{"@value":"Edith Pituskin John R. Mackey, Sheri Koshman, Mark J. Haykowsky, Joseph J. Pagano, Kelvin Chow, Richard B. Thompson, Larissa J. Vos, Sunita Ghosh, Gavin Y. Oudit, Justin A. Ezekowitz, and D. Ian Paterson, University of Alberta, Edmonton, Alberta; and Davinder Jassal and Marshall Pitz, University of Manitoba, Winnipeg, Manitoba, Canada."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995419103235","@type":"Researcher","foaf:name":[{"@value":"Richard B. Thompson"}],"jpcoar:affiliationName":[{"@value":"Edith Pituskin John R. Mackey, Sheri Koshman, Mark J. Haykowsky, Joseph J. Pagano, Kelvin Chow, Richard B. Thompson, Larissa J. Vos, Sunita Ghosh, Gavin Y. Oudit, Justin A. Ezekowitz, and D. Ian Paterson, University of Alberta, Edmonton, Alberta; and Davinder Jassal and Marshall Pitz, University of Manitoba, Winnipeg, Manitoba, Canada."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995419103110","@type":"Researcher","foaf:name":[{"@value":"Larissa J. Vos"}],"jpcoar:affiliationName":[{"@value":"Edith Pituskin John R. Mackey, Sheri Koshman, Mark J. Haykowsky, Joseph J. Pagano, Kelvin Chow, Richard B. Thompson, Larissa J. Vos, Sunita Ghosh, Gavin Y. Oudit, Justin A. Ezekowitz, and D. Ian Paterson, University of Alberta, Edmonton, Alberta; and Davinder Jassal and Marshall Pitz, University of Manitoba, Winnipeg, Manitoba, Canada."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995419103105","@type":"Researcher","foaf:name":[{"@value":"Sunita Ghosh"}],"jpcoar:affiliationName":[{"@value":"Edith Pituskin John R. Mackey, Sheri Koshman, Mark J. Haykowsky, Joseph J. Pagano, Kelvin Chow, Richard B. Thompson, Larissa J. Vos, Sunita Ghosh, Gavin Y. Oudit, Justin A. Ezekowitz, and D. Ian Paterson, University of Alberta, Edmonton, Alberta; and Davinder Jassal and Marshall Pitz, University of Manitoba, Winnipeg, Manitoba, Canada."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995419103234","@type":"Researcher","foaf:name":[{"@value":"Gavin Y. Oudit"}],"jpcoar:affiliationName":[{"@value":"Edith Pituskin John R. Mackey, Sheri Koshman, Mark J. Haykowsky, Joseph J. Pagano, Kelvin Chow, Richard B. Thompson, Larissa J. Vos, Sunita Ghosh, Gavin Y. Oudit, Justin A. Ezekowitz, and D. Ian Paterson, University of Alberta, Edmonton, Alberta; and Davinder Jassal and Marshall Pitz, University of Manitoba, Winnipeg, Manitoba, Canada."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995419103236","@type":"Researcher","foaf:name":[{"@value":"Justin A. Ezekowitz"}],"jpcoar:affiliationName":[{"@value":"Edith Pituskin John R. Mackey, Sheri Koshman, Mark J. Haykowsky, Joseph J. Pagano, Kelvin Chow, Richard B. Thompson, Larissa J. Vos, Sunita Ghosh, Gavin Y. Oudit, Justin A. Ezekowitz, and D. Ian Paterson, University of Alberta, Edmonton, Alberta; and Davinder Jassal and Marshall Pitz, University of Manitoba, Winnipeg, Manitoba, Canada."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995419103111","@type":"Researcher","foaf:name":[{"@value":"D. Ian Paterson"}],"jpcoar:affiliationName":[{"@value":"Edith Pituskin John R. Mackey, Sheri Koshman, Mark J. Haykowsky, Joseph J. Pagano, Kelvin Chow, Richard B. Thompson, Larissa J. Vos, Sunita Ghosh, Gavin Y. Oudit, Justin A. Ezekowitz, and D. Ian Paterson, University of Alberta, Edmonton, Alberta; and Davinder Jassal and Marshall Pitz, University of Manitoba, Winnipeg, Manitoba, Canada."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0732183X"},{"@type":"EISSN","@value":"15277755"}],"prism:publicationName":[{"@value":"Journal of Clinical Oncology"}],"dc:publisher":[{"@value":"American Society of Clinical Oncology (ASCO)"}],"prism:publicationDate":"2017-03-10","prism:volume":"35","prism:number":"8","prism:startingPage":"870","prism:endingPage":"877"},"reviewed":"false","url":[{"@id":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2016.68.7830"}],"createdAt":"2017-02-23","modifiedAt":"2022-05-29","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360298757182795264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cancer therapeutics-related cardiovascular dysfunction: Basic mechanisms and clinical manifestation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181176582912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cardioprotective effect of renin–angiotensin inhibitors and β-blockers in trastuzumab-related cardiotoxicity"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001277373590656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Impending Epidemic of Cardiovascular Diseases in Patients With Cancer in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1390019977295888896","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"1) Cancer Therapy-related Cardiac Dysfunction"},{"@language":"ja","@value":"1）がん治療関連心機能障害―現状と課題―"}]},{"@id":"https://cir.nii.ac.jp/crid/1390856995346467200","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Usefulness of Global Longitudinal Strain-Guided Management in Preventing Human Epidermal Growth Factor Receptor 2 (HER2) Inhibitor-Induced Myocardial Damage"}]},{"@id":"https://cir.nii.ac.jp/crid/1390868361811955712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Trastuzumab Cardiotoxicity: Mechanism and Management"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1200/jco.2016.68.7830"},{"@type":"CROSSREF","@value":"10.1248/bpb.b25-00235_references_DOI_1pdSiT6ZgaClIVMBbSCVNN7bHtC"},{"@type":"CROSSREF","@value":"10.1253/circrep.cr-22-0094_references_DOI_1pdSiT6ZgaClIVMBbSCVNN7bHtC"},{"@type":"CROSSREF","@value":"10.1016/j.jjcc.2022.04.006_references_DOI_1pdSiT6ZgaClIVMBbSCVNN7bHtC"},{"@type":"CROSSREF","@value":"10.1007/s00392-019-01448-4_references_DOI_1pdSiT6ZgaClIVMBbSCVNN7bHtC"},{"@type":"CROSSREF","@value":"10.2169/naika.112.1566_references_DOI_1pdSiT6ZgaClIVMBbSCVNN7bHtC"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-19-0426_references_DOI_1pdSiT6ZgaClIVMBbSCVNN7bHtC"}]}