{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699995452956288.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1089/neu.2010.1540"}},{"identifier":{"@type":"URI","@value":"https://journals.sagepub.com/doi/full-xml/10.1089/neu.2010.1540"}},{"identifier":{"@type":"URI","@value":"https://journals.sagepub.com/doi/pdf/10.1089/neu.2010.1540"}}],"dc:title":[{"@value":"Blast Exposure in Rats with Body Shielding Is Characterized Primarily by Diffuse Axonal Injury"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Blast-induced traumatic brain injury (TBI) is the signature insult in combat casualty care. Survival with neurological damage from otherwise lethal blast exposures has become possible with body armor use. We characterized the neuropathologic alterations produced by a single blast exposure in rats using a helium-driven shock tube to generate a nominal exposure of 35 pounds per square inch (PSI) (positive phase duration ∼4 msec). Using an IACUC-approved protocol, isoflurane-anesthetized rats were placed in a steel wedge (to shield the body) 7 feet inside the end of the tube. The left side faced the blast wave (with head-only exposure); the wedge apex focused a Mach stem onto the rat's head. The insult produced ∼25% mortality (due to impact apnea). Surviving and sham rats were perfusion-fixed at 24 h, 72 h, or 2 weeks post-blast. Neuropathologic evaluations were performed utilizing hematoxylin and eosin, amino cupric silver, and a variety of immunohistochemical stains for amyloid precursor protein (APP), glial fibrillary acidic protein (GFAP), ionized calcium-binding adapter molecule 1 (Iba1), ED1, and rat IgG. Multifocal axonal degeneration, as evidenced by staining with amino cupric silver, was present in all blast-exposed rats at all time points. Deep cerebellar and brainstem white matter tracts were most heavily stained with amino cupric silver, with the morphologic staining patterns suggesting a process of diffuse axonal injury. Silver-stained sections revealed mild multifocal neuronal death at 24 h and 72 h. GFAP, ED1, and Iba1 staining were not prominently increased, although small numbers of reactive microglia were seen within areas of neuronal death. Increased blood–brain barrier permeability (as measured by IgG staining) was seen at 24 h and primarily affected the contralateral cortex. Axonal injury was the most prominent feature during the initial 2 weeks following blast exposure, although degeneration of other neuronal processes was also present. Strikingly, silver staining revealed otherwise undetected abnormalities, and therefore represents a recommended outcome measure in future studies of blast TBI.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699995452956162","@type":"Researcher","foaf:name":[{"@value":"Robert H. Garman"}],"jpcoar:affiliationName":[{"@value":"University of Pittsburgh School of Medicine"},{"@value":"University of Pittsburgh School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995452956163","@type":"Researcher","foaf:name":[{"@value":"Larry W. Jenkins"}],"jpcoar:affiliationName":[{"@value":"University of Pittsburgh School of Medicine"},{"@value":"University of Pittsburgh School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995452956289","@type":"Researcher","foaf:name":[{"@value":"Robert C. Switzer"}],"jpcoar:affiliationName":[{"@value":"NeuroScience Associates"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995452956292","@type":"Researcher","foaf:name":[{"@value":"Richard A. Bauman"}],"jpcoar:affiliationName":[{"@value":"Walter Reed Army Institute of Research"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995452956291","@type":"Researcher","foaf:name":[{"@value":"Lawrence C. Tong"}],"jpcoar:affiliationName":[{"@value":"Walter Reed Army Institute of Research"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995452956165","@type":"Researcher","foaf:name":[{"@value":"Peter V. Swauger"}],"jpcoar:affiliationName":[{"@value":"ORA Inc"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995452956160","@type":"Researcher","foaf:name":[{"@value":"Steven A. Parks"}],"jpcoar:affiliationName":[{"@value":"ORA Inc"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995452956288","@type":"Researcher","foaf:name":[{"@value":"David V. Ritzel"}],"jpcoar:affiliationName":[{"@value":"Dyn-FX Consulting Ltd"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995452956290","@type":"Researcher","foaf:name":[{"@value":"C. Edward Dixon"}],"jpcoar:affiliationName":[{"@value":"University of Pittsburgh School of Medicine"},{"@value":"University of Pittsburgh School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995452956161","@type":"Researcher","foaf:name":[{"@value":"Robert S.B. Clark"}],"jpcoar:affiliationName":[{"@value":"University of Pittsburgh School of Medicine"},{"@value":"University of Pittsburgh School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995452956164","@type":"Researcher","foaf:name":[{"@value":"Hülya Bayır"}],"jpcoar:affiliationName":[{"@value":"University of Pittsburgh School of Medicine"},{"@value":"University of Pittsburgh School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995452956166","@type":"Researcher","foaf:name":[{"@value":"Valerian Kagan"}],"jpcoar:affiliationName":[{"@value":"University of Pittsburgh School of Medicine"},{"@value":"University of Pittsburgh School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995452956294","@type":"Researcher","foaf:name":[{"@value":"Edwin K. Jackson"}],"jpcoar:affiliationName":[{"@value":"University of Pittsburgh School of Medicine"},{"@value":"University of Pittsburgh School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995452956293","@type":"Researcher","foaf:name":[{"@value":"Patrick M. Kochanek"}],"jpcoar:affiliationName":[{"@value":"University of Pittsburgh School of Medicine"},{"@value":"University of Pittsburgh School of Medicine"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"08977151"},{"@type":"EISSN","@value":"15579042"}],"prism:publicationName":[{"@value":"Journal of Neurotrauma"}],"dc:publisher":[{"@value":"SAGE Publications"}],"prism:publicationDate":"2011-06","prism:volume":"28","prism:number":"6","prism:startingPage":"947","prism:endingPage":"959"},"reviewed":"false","dc:rights":["https://journals.sagepub.com/page/policies/text-and-data-mining-license"],"url":[{"@id":"https://journals.sagepub.com/doi/full-xml/10.1089/neu.2010.1540"},{"@id":"https://journals.sagepub.com/doi/pdf/10.1089/neu.2010.1540"}],"createdAt":"2011-03-30","modifiedAt":"2026-03-11","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360290617515714688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Axonal damage and behavioral deficits in rats with repetitive exposure of the brain to laser-induced shock waves: Effects of inter-exposure time"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567189641483392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pathophysiology of microwave-induced traumatic brain injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848660803485568","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Multispectral imaging of cortical vascular and hemodynamic responses to a shock wave: observation of spreading depolarization and oxygen supply-demand mismatch"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1089/neu.2010.1540"},{"@type":"CROSSREF","@value":"10.1016/j.neulet.2021.135722_references_DOI_MoVeVJVjwedOfmHHFYLNU8fVY0E"},{"@type":"CROSSREF","@value":"10.1117/1.jbo.24.3.035005_references_DOI_MoVeVJVjwedOfmHHFYLNU8fVY0E"},{"@type":"CROSSREF","@value":"10.3892/br.2015.454_references_DOI_MoVeVJVjwedOfmHHFYLNU8fVY0E"}]}