{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699995458779392.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1007/s12185-007-0005-z"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s12185-007-0005-z.pdf"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/article/10.1007/s12185-007-0005-z/fulltext.html"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s12185-007-0005-z"}},{"identifier":{"@type":"PMID","@value":"18224415"}}],"dc:title":[{"@value":"Administration of factor XIII B subunit increased plasma factor XIII A subunit levels in factor XIII B subunit knock-out mice"}],"description":[{"notation":[{"@value":"Factor XIII (FXIII) is a proenzyme of plasma transglutaminase consisting of enzymatic A (FXIII-A) and noncatalytic B subunits (FXIII-B), and acts in hemostasis and wound healing. We freshly generated mice lacking either FXIII-A or FXIII-B to investigate the physiological functions of FXIII in vivo. Mice carrying the disrupted allele were born at the expected Mendelian ratios, and the homozygous mice were viable and fertile under specific pathogen-free conditions. Although all homozygous and heterozygous mice showed no marked difference from the wild-type animals in general appearance, homozygous mice of either FXIII-A- or FXIII-B-deficiency did have prolonged bleeding times. It was confirmed that thrombin-dependent amine incorporation and fibrin-crosslinking in plasma were undetectable in the FXIII-A-deficient mice and markedly reduced in the FXIII-B-deficient mice; however, the gene expression of each subunit was regulated independently. Recombinant human FXIII-B (rFXIII-B) was expressed in a baculovirus expression system. When rFXIII-B was injected into FXIII-B-deficient mice, FXIII-A levels, fibrin crosslinking, and amine-incorporation activities increased in their plasma, indicating that FXIII-B assisted the maintenance of FXIII-A levels in the circulation. These mouse strains will be useful in exploring the possible pathophysiological roles of each subunit in vivo."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699995458779393","@type":"Researcher","foaf:name":[{"@value":"Masayoshi Souri"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995458779394","@type":"Researcher","foaf:name":[{"@value":"Shiori Koseki-Kuno"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995458779395","@type":"Researcher","foaf:name":[{"@value":"Naoki Takeda"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995458779392","@type":"Researcher","foaf:name":[{"@value":"Jay L. Degen"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995458779396","@type":"Researcher","foaf:name":[{"@value":"Akitada Ichinose"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09255710"},{"@type":"EISSN","@value":"18653774"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/09255710"}],"prism:publicationName":[{"@value":"International Journal of Hematology"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2007-12-05","prism:volume":"87","prism:number":"1","prism:startingPage":"60","prism:endingPage":"68"},"reviewed":"false","dc:rights":["http://www.springer.com/tdm"],"url":[{"@id":"http://link.springer.com/content/pdf/10.1007/s12185-007-0005-z.pdf"},{"@id":"http://link.springer.com/article/10.1007/s12185-007-0005-z/fulltext.html"},{"@id":"http://link.springer.com/content/pdf/10.1007/s12185-007-0005-z"}],"createdAt":"2008-01-15","modifiedAt":"2020-04-30","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Knockout","dc:title":"Mice, Knockout"},{"@id":"https://cir.nii.ac.jp/all?q=Factor%20XIII","dc:title":"Factor XIII"},{"@id":"https://cir.nii.ac.jp/all?q=Factor%20XIII%20Deficiency","dc:title":"Factor XIII Deficiency"},{"@id":"https://cir.nii.ac.jp/all?q=Recombinant%20Proteins","dc:title":"Recombinant Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Models,%20Animal","dc:title":"Disease Models, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360283690462887808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Factor XIII is a key molecule at the intersection of coagulation and fibrinolysis as well as inflammation and infection control"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707506124928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Molecular modeling predicts structural changes in the A subunit of factor XIII caused by two novel mutations identified in a neonate with severe congenital factor XIII deficiency"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285711389724160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Alloantibodies against the B subunit of plasma factor XIII developed in its congenital deficiency"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182482990464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Non-autoimmune combined factor XIII A and B subunit deficiencies in rheumatoid arthritis patients treated with anti-interleukin-6 receptor monoclonal antibody (tocilizumab)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183935130624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Non-catalytic B Subunit of Coagulation Factor XIII Accelerates Fibrin 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