{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699995472011008.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/j.1600-0643.2007.00602.x"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1600-0643.2007.00602.x"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-0643.2007.00602.x"}}],"dc:title":[{"@value":"Expression of CD44s and CD44v6 in transitional cell carcinomas of the urinary bladder: comparison with tumour grade, proliferative activity and p53 immunoreactivity of tumour cells"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Alterations of CD44 glycoproteins have been shown to play an important role in progression of various malignancies, including urothelial cancer. We investigated expression patterns of CD44s and CD44v6 in transitional cell carcinoma (TCC) of the urinary bladder in relation to tumour grade, proliferative activity, and immunoreactivity for p53. The selected markers were detected immunohistochemically in 122 samples of TCC. We found a close relationship between CD44s and CD44v6 expression and tumour grade. The extension of positive staining for CD44s and CD44v6 towards the luminal surface was a predominant feature of differentiated carcinomas (grades 1 and 2), suggesting deranged maturation of cancer cells related to their neoplastic transformation. Heterogeneous expression of CD44s and CD44v6 predominated in poorly differentiated tumours (G3–4). However, areas of squamous differentiation within the high‐grade tumours displayed strong immunoreactivity for both CD44s and CD44v6. The proliferative activity and p53 overexpression increased with the dedifferentiation of the tumour. The results of this study are discussed in relation to the significance of CD44 expression in TCC and to the explanation for controversial results reported in previous studies on the relationship between CD44 expression and the biological behaviour of urothelial cells.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699995472011008","@type":"Researcher","foaf:name":[{"@value":"JITKA KUNCOVÁ"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995472011010","@type":"Researcher","foaf:name":[{"@value":"MICHAEL URBAN"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995472011009","@type":"Researcher","foaf:name":[{"@value":"VÁCLAV MANDYS"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09034641"},{"@type":"EISSN","@value":"16000463"}],"prism:publicationName":[{"@value":"APMIS"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2007-11","prism:volume":"115","prism:number":"11","prism:startingPage":"1194","prism:endingPage":"1205"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1600-0643.2007.00602.x"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-0643.2007.00602.x"}],"createdAt":"2009-01-22","modifiedAt":"2023-10-11","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002218666226944","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nuclear Localization of COX-2 in relation to the Expression of Stemness Markers in Urinary Bladder Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710590701184","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"CD44 in human glioma correlates with histopathological grade and cell migration"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567186307693184","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Inflammation-Related DNA Damage and Cancer Stem Cell Markers in Nasopharyngeal Carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643598585728","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"DNA Damage in Inflammation-Related Carcinogenesis and Cancer Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362257544105467264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Emerging Roles of Cancer Stem Cells in Bladder Cancer Progression, Tumorigenesis, and Resistance to Chemotherapy: A Potential Therapeutic Target for Bladder Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/2050307416982594944","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nitrative and oxidative DNA damage in infection-related carcinogenesis in relation to cancer stem cells"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/j.1600-0643.2007.00602.x"},{"@type":"CROSSREF","@value":"10.1155/2012/165879_references_DOI_DoOBCIDl5w88mujVWd1BuUAUHDx"},{"@type":"CROSSREF","@value":"10.1186/s41021-016-0055-7_references_DOI_DoOBCIDl5w88mujVWd1BuUAUHDx"},{"@type":"CROSSREF","@value":"10.1111/j.1440-1827.2012.02823.x_references_DOI_DoOBCIDl5w88mujVWd1BuUAUHDx"},{"@type":"CROSSREF","@value":"10.1155/2016/9343460_references_DOI_DoOBCIDl5w88mujVWd1BuUAUHDx"},{"@type":"CROSSREF","@value":"10.1155/2013/387014_references_DOI_DoOBCIDl5w88mujVWd1BuUAUHDx"},{"@type":"CROSSREF","@value":"10.1186/s41021-016-0070-8_references_DOI_DoOBCIDl5w88mujVWd1BuUAUHDx"},{"@type":"CROSSREF","@value":"10.3390/cells9010235_references_DOI_DoOBCIDl5w88mujVWd1BuUAUHDx"}]}