{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699995516624256.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/science.3317830"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/science.3317830"}}],"dc:title":[{"@value":"Efflux of Chloroquine from\n            <i>Plasmodium falciparum</i>\n            : Mechanism of Chloroquine Resistance"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n            Chloroquine-resistant\n            <jats:italic>Plasmodium falciparum</jats:italic>\n            accumulate significantly less chloroquine than susceptible parasites, and this is thought to be the basis of their resistance. However, the reason for the lower accumulation of chloroquine was unknown. The resistant parasite has now been found to release chloroquine 40 to 50 times more rapidly than the susceptible parasite, although their initial rates of chloroquine accumulation are the same. Verapamil and two other calcium channel blockers, as well as vinblastine and daunomycin, each slowed the release and increased the accumulation of chloroquine by resistant (but not susceptible)\n            <jats:italic>Plasmodium falciparum</jats:italic>\n            . These results suggest that a higher rate of chloroquine release explains the lower chloroquine accumulation, and thus the resistance observed in resistant\n            <jats:italic>Plasmodium falciparum</jats:italic>\n            .\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699995516624258","@type":"Researcher","foaf:name":[{"@value":"Donald J. Krogstad"}],"jpcoar:affiliationName":[{"@value":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995516624128","@type":"Researcher","foaf:name":[{"@value":"Ilya Y. Gluzman"}],"jpcoar:affiliationName":[{"@value":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995516624130","@type":"Researcher","foaf:name":[{"@value":"Dennis E. Kyle"}],"jpcoar:affiliationName":[{"@value":"Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC 20307."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995516624129","@type":"Researcher","foaf:name":[{"@value":"Ayoade M. J. Oduola"}],"jpcoar:affiliationName":[{"@value":"Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC 20307."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995516624259","@type":"Researcher","foaf:name":[{"@value":"Samuel K. Martin"}],"jpcoar:affiliationName":[{"@value":"Division of Medicine, Walter Reed Army Institute of Research, Washington, DC 20307."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995516624256","@type":"Researcher","foaf:name":[{"@value":"Wilbur K. Milhous"}],"jpcoar:affiliationName":[{"@value":"Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC 20307."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995516624257","@type":"Researcher","foaf:name":[{"@value":"Paul H. Schlesinger"}],"jpcoar:affiliationName":[{"@value":"Department of Biomedical Research at Washington University School of Dental Medicine, St. Louis, MO 63110."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00368075"},{"@type":"EISSN","@value":"10959203"}],"prism:publicationName":[{"@value":"Science"}],"dc:publisher":[{"@value":"American Association for the Advancement of Science (AAAS)"}],"prism:publicationDate":"1987-11-27","prism:volume":"238","prism:number":"4831","prism:startingPage":"1283","prism:endingPage":"1285"},"reviewed":"false","url":[{"@id":"https://www.science.org/doi/pdf/10.1126/science.3317830"}],"createdAt":"2006-10-05","modifiedAt":"2024-01-14","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360846644039977088","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A Simple Synthetic Method for 3-Trifluoroacetylated 4-Aminoquinolines from 4-Dimethylaminoquinoline by Novel Trifluoroacetylation and N-N Exchange Reactions"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206239889152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"IN VITRO REVERSAL OF CHLOROQUINE RESISTANCE WITH CHLORPHENIRAMINE AGAINST AFRICAN ISOLATES OF <I>PLASMODIUM FALCIPARUM</I>"},{"@value":"IN VITRO REVERSAL OF CHLOROQUINE RESISTANCE WITH CHLORPHENIRAMINE AGAINST AFRICAN ISOLATES OF PLASMODIUM FALCIPARUM"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206242033536","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Evolution of <i>Plasmodium falciparum</i> drug resistance: implications for the development and containment of artemisinin resistance"},{"@value":"Evolution of Plasmodium falciparum drug resistance : implications for the development and containment of artemisinin resistance"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681405340032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Development and Characterization of a Strain of Babesia gibsoni Resistant to Diminazene Aceturate In Vitro"},{"@value":"Internal medicine: Development and characterization of a strain of Babesia gibsoni resistant to diminazene aceturate in vitro"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1126/science.3317830"},{"@type":"CROSSREF","@value":"10.7883/yoken.65.465_references_DOI_1vNevbIXy96TSgJgWoRL4lVHTCH"},{"@type":"CROSSREF","@value":"10.7883/yoken1952.47.59_references_DOI_1vNevbIXy96TSgJgWoRL4lVHTCH"},{"@type":"CROSSREF","@value":"10.1246/cl.2000.50_references_DOI_1vNevbIXy96TSgJgWoRL4lVHTCH"},{"@type":"CROSSREF","@value":"10.1292/jvms.09-0535_references_DOI_1vNevbIXy96TSgJgWoRL4lVHTCH"}]}