{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699995524034304.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1161/hypertensionaha.118.12462"}},{"identifier":{"@type":"URI","@value":"https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.118.12462"}}],"dc:title":[{"@value":"Elevated Muscle Sympathetic Nerve Activity Contributes to Central Artery Stiffness in Young and Middle-Age/Older Adults"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n            Muscle sympathetic nerve activity (MSNA) influences the mechanical properties (ie, vascular smooth muscle tone and stiffness) of peripheral arteries, but it remains controversial whether MSNA contributes to stiffness of central arteries, such as the aorta and carotids. We examined whether elevated MSNA (age-related) would be independently associated with greater stiffness of central (carotid-femoral pulse wave velocity [PWV]) and peripheral (carotid-brachial PWV) arteries, in addition to lower carotid compliance coefficient, in healthy men and women (n=88, age: 19–73 years, 52% men). We also examined whether acute elevations in MSNA without increases in mean arterial pressure using graded levels of lower body negative pressure would augment central and peripheral artery stiffness in young (n=15, 60% men) and middle-age/older (MA/O, n=14, 43% men) adults. Resting MSNA burst frequency (bursts·min\n            <jats:sup>−1</jats:sup>\n            ) was significantly correlated with carotid-femoral PWV (\n            <jats:italic>R</jats:italic>\n            =0.44,\n            <jats:italic>P</jats:italic>\n            <0.001), carotid-brachial PWV (\n            <jats:italic>R</jats:italic>\n            =0.32,\n            <jats:italic>P</jats:italic>\n            =0.004), and carotid compliance coefficient (\n            <jats:italic>R</jats:italic>\n            =0.28,\n            <jats:italic>P</jats:italic>\n            =0.01) after controlling for sex, mean arterial pressure, heart rate, and waist-to-hip ratio (central obesity), but these correlations were abolished after further controlling for age (all\n            <jats:italic>P</jats:italic>\n            >0.05). In young and MA/O adults, MSNA was elevated during lower body negative pressure (\n            <jats:italic>P</jats:italic>\n            <0.001) and produced significant increases in carotid-femoral PWV (young: Δ+1.3±0.3 versus MA/O: Δ+1.0±0.3 m·s\n            <jats:sup>−1</jats:sup>\n            ,\n            <jats:italic>P</jats:italic>\n            =0.53) and carotid-brachial PWV (young: Δ+0.7±0.3 versus MA/O: Δ+0.7±0.5 m·s\n            <jats:sup>−1</jats:sup>\n            ,\n            <jats:italic>P</jats:italic>\n            =0.92), whereas carotid compliance coefficient during lower body negative pressure was significantly reduced in young but not MA/O (young: Δ−0.04±0.01 versus MA/O: Δ0.001±0.008 mm\n            <jats:sup>2</jats:sup>\n            ·mm Hg\n            <jats:sup>−1</jats:sup>\n            ,\n            <jats:italic>P</jats:italic>\n            <0.01). Collectively, these data demonstrate the influence of MSNA on central artery stiffness and its potential contribution to age-related increases in stiffness of both peripheral and central arteries.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699995524034311","@type":"Researcher","foaf:name":[{"@value":"Seth W. Holwerda"}],"jpcoar:affiliationName":[{"@value":"From the Department of Health and Human Physiology (S.W.H., R.E.L., M.T.C., N.A.W., G.L.P.)"},{"@value":"Abboud Cardiovascular Research Center (S.W.H., F.M.A., G.L.P.)"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995524034312","@type":"Researcher","foaf:name":[{"@value":"Rachel E. Luehrs"}],"jpcoar:affiliationName":[{"@value":"From the Department of Health and Human Physiology (S.W.H., R.E.L., M.T.C., N.A.W., G.L.P.)"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995524034308","@type":"Researcher","foaf:name":[{"@value":"Lyndsey DuBose"}],"jpcoar:affiliationName":[{"@value":"University of Iowa (L.D.)"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995524034304","@type":"Researcher","foaf:name":[{"@value":"Michael T. Collins"}],"jpcoar:affiliationName":[{"@value":"From the Department of Health and Human Physiology (S.W.H., R.E.L., M.T.C., N.A.W., G.L.P.)"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995524034307","@type":"Researcher","foaf:name":[{"@value":"Nealy A. Wooldridge"}],"jpcoar:affiliationName":[{"@value":"From the Department of Health and Human Physiology (S.W.H., R.E.L., M.T.C., N.A.W., G.L.P.)"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995524034305","@type":"Researcher","foaf:name":[{"@value":"Amy K. Stroud"}],"jpcoar:affiliationName":[{"@value":"Department of Psychiatry (A.K.S.)"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995524034309","@type":"Researcher","foaf:name":[{"@value":"Paul J. Fadel"}],"jpcoar:affiliationName":[{"@value":"Department of Kinesiology, University of Texas at Arlington (P.J.F.)."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995524034310","@type":"Researcher","foaf:name":[{"@value":"Francois M. Abboud"}],"jpcoar:affiliationName":[{"@value":"Abboud Cardiovascular Research Center (S.W.H., F.M.A., G.L.P.)"},{"@value":"Department of Internal Medicine (F.M.A.)"},{"@value":"Department of Molecular Physiology and Biophysics (F.M.A.)"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995524034306","@type":"Researcher","foaf:name":[{"@value":"Gary L. Pierce"}],"jpcoar:affiliationName":[{"@value":"From the Department of Health and Human Physiology (S.W.H., R.E.L., M.T.C., N.A.W., G.L.P.)"},{"@value":"Abboud Cardiovascular Research Center (S.W.H., F.M.A., G.L.P.)"},{"@value":"Fraternal Order of Eagles Diabetes Research Center (G.L.P.)"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0194911X"},{"@type":"EISSN","@value":"15244563"}],"prism:publicationName":[{"@value":"Hypertension"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2019-05","prism:volume":"73","prism:number":"5","prism:startingPage":"1025","prism:endingPage":"1035"},"reviewed":"false","url":[{"@id":"https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.118.12462"}],"createdAt":"2019-03-25","modifiedAt":"2024-05-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360021391885951488","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Age- and sex-related differences in sympathetic vascular transduction and neurohemodynamic balance in humans"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617479959168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Impact of acute mental stress on segmental arterial stiffness"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306904418828160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The validity of carotid-femoral pulse wave velocity in the seated posture as an index of central arterial stiffness"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584340538847104","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Acute social jetlag augments morning blood pressure surge: a randomized crossover trial"}]},{"@id":"https://cir.nii.ac.jp/crid/1390015333248178816","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Detrimental impacts of acute mental stress on arterial function and exercise as a countermeasure"}]},{"@id":"https://cir.nii.ac.jp/crid/1390866293391898496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of Powdered <i>Morus australis</i> Leaves on Arterial Stiffness Response after Sucrose Ingestion in Healthy Young Men: A Pilot Study"},{"@value":"Effect of Powdered Morus australis Leaves on Arterial Stiffness Response after Sucrose Ingestion in Healthy Young Men : A Pilot Study"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1161/hypertensionaha.118.12462"},{"@type":"CROSSREF","@value":"10.7600/jpfsm.12.95_references_DOI_GE5V01fnsADJn8xe3RZG77GCVqz"},{"@type":"CROSSREF","@value":"10.1152/ajpheart.00301.2023_references_DOI_GE5V01fnsADJn8xe3RZG77GCVqz"},{"@type":"CROSSREF","@value":"10.3177/jnsv.71.63_references_DOI_GE5V01fnsADJn8xe3RZG77GCVqz"},{"@type":"CROSSREF","@value":"10.1007/s00421-020-04448-9_references_DOI_GE5V01fnsADJn8xe3RZG77GCVqz"},{"@type":"CROSSREF","@value":"10.1152/ajpregu.00073.2024_references_DOI_GE5V01fnsADJn8xe3RZG77GCVqz"},{"@type":"CROSSREF","@value":"10.1038/s41440-023-01360-5_references_DOI_GE5V01fnsADJn8xe3RZG77GCVqz"}]}