{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699995536866176.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/nmeth.3440"}},{"identifier":{"@type":"URI","@value":"http://www.nature.com/articles/nmeth.3440.pdf"}},{"identifier":{"@type":"URI","@value":"http://www.nature.com/articles/nmeth.3440"}},{"identifier":{"@type":"PMID","@value":"26125594"}},{"identifier":{"@type":"HANDLE","@value":"10230/36284"}}],"dc:title":[{"@value":"Pathway and network analysis of cancer genomes"}],"description":[{"notation":[{"@value":"Genomic information on tumors from 50 cancer types cataloged by the International Cancer Genome Consortium (ICGC) shows that only a few well-studied driver genes are frequently mutated, in contrast to many infrequently mutated genes that may also contribute to tumor biology. Hence there has been large interest in developing pathway and network analysis methods that group genes and illuminate the processes involved. We provide an overview of these analysis techniques and show where they guide mechanistic and translational investigations."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1892273590612868367","@type":"Researcher","foaf:name":[{"@value":"Reimand, Juri"}]},{"@id":"https://cir.nii.ac.jp/crid/1892273590612868363","@type":"Researcher","foaf:name":[{"@value":"Gonzalez-Perez, Abel"}]},{"@id":"https://cir.nii.ac.jp/crid/1892273590612868366","@type":"Researcher","foaf:name":[{"@value":"Vazquez, Miguel"}]},{"@id":"https://cir.nii.ac.jp/crid/1892273590612868227","@type":"Researcher","foaf:name":[{"@value":"Pearson, John"}]},{"@id":"https://cir.nii.ac.jp/crid/1892273590612868357","@type":"Researcher","foaf:name":[{"@value":"Mustonen, Ville"}]},{"@id":"https://cir.nii.ac.jp/crid/1892273590612868358","@type":"Researcher","foaf:name":[{"@value":"Sander, Chris"}]},{"@id":"https://cir.nii.ac.jp/crid/1892273590612868356","@type":"Researcher","foaf:name":[{"@value":"Raphael, Benjamin J."}]},{"@id":"https://cir.nii.ac.jp/crid/1892273590612868353","@type":"Researcher","foaf:name":[{"@value":"Marks, Debora S."}]},{"@id":"https://cir.nii.ac.jp/crid/1892273590612868352","@type":"Researcher","foaf:name":[{"@value":"Ouellette, B. 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Francis"}]},{"@id":"https://cir.nii.ac.jp/crid/1892273590612868354","@type":"Researcher","foaf:name":[{"@value":"Valencia, Alfonso"}]},{"@id":"https://cir.nii.ac.jp/crid/1892273590612868355","@type":"Researcher","foaf:name":[{"@value":"Boutros, Paul C."}]},{"@id":"https://cir.nii.ac.jp/crid/1892273590612868359","@type":"Researcher","foaf:name":[{"@value":"Bader, Gary D."}]},{"@id":"https://cir.nii.ac.jp/crid/1892273590612868361","@type":"Researcher","foaf:name":[{"@value":"Creixell, Pau"}]},{"@id":"https://cir.nii.ac.jp/crid/1892273590612868226","@type":"Researcher","foaf:name":[{"@value":"Haider, Syed"}]},{"@id":"https://cir.nii.ac.jp/crid/1892273590612868364","@type":"Researcher","foaf:name":[{"@value":"Stuart, Joshua M."}]},{"@id":"https://cir.nii.ac.jp/crid/1892273590612868225","@type":"Researcher","foaf:name":[{"@value":"Wu, Guanming"}]},{"@id":"https://cir.nii.ac.jp/crid/1892273590612868228","@type":"Researcher","foaf:name":[{"@value":"Linding, Rune"}]},{"@id":"https://cir.nii.ac.jp/crid/1892273590612868224","@type":"Researcher","foaf:name":[{"@value":"Lopez-Bigas, Nuria"}]},{"@id":"https://cir.nii.ac.jp/crid/1892273590612868362","@type":"Researcher","foaf:name":[{"@value":"Stein, Lincoln D."}]},{"@id":"https://cir.nii.ac.jp/crid/1892273590612868365","@type":"Researcher","foaf:name":[{"@value":"Shibata, Tatsuhiro"}]},{"@id":"https://cir.nii.ac.jp/crid/1892273590612868360","@type":"Researcher","foaf:name":[{"@value":"International Cancer Genome Consortium"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"15487091"},{"@type":"EISSN","@value":"15487105"}],"prism:publicationName":[{"@value":"Nature Methods"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2015-06-30","prism:volume":"12","prism:number":"7","prism:startingPage":"615","prism:endingPage":"621"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://www.springer.com/tdm"],"url":[{"@id":"http://www.nature.com/articles/nmeth.3440.pdf"},{"@id":"http://www.nature.com/articles/nmeth.3440"}],"createdAt":"2015-06-30","modifiedAt":"2023-05-18","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=1303%20Biochemistry","dc:title":"1303 Biochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Genome","dc:title":"Genome"},{"@id":"https://cir.nii.ac.jp/all?q=Pathway%20and%20network%20analysis","dc:title":"Pathway and network analysis"},{"@id":"https://cir.nii.ac.jp/all?q=Tumors%20--%20Gen%C3%A8tica","dc:title":"Tumors -- Genètica"},{"@id":"https://cir.nii.ac.jp/all?q=1307%20Cell%20Biology","dc:title":"1307 Cell Biology"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasms","dc:title":"Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=1305%20Biotechnology","dc:title":"1305 Biotechnology"},{"@id":"https://cir.nii.ac.jp/all?q=1312%20Molecular%20Biology","dc:title":"1312 Molecular Biology"},{"@id":"https://cir.nii.ac.jp/all?q=Driver%20genes","dc:title":"Driver genes"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Regulatory%20Networks","dc:title":"Gene Regulatory Networks"},{"@id":"https://cir.nii.ac.jp/all?q=Cancer%20genomes","dc:title":"Cancer genomes"},{"@id":"https://cir.nii.ac.jp/all?q=Genomes","dc:title":"Genomes"},{"@id":"https://cir.nii.ac.jp/all?q=Gen%C3%A8tica","dc:title":"Genètica"},{"@id":"https://cir.nii.ac.jp/all?q=Tumors","dc:title":"Tumors"},{"@id":"https://cir.nii.ac.jp/all?q=Signal%20Transduction","dc:title":"Signal Transduction"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360848660745511424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Genomic pathobiology of gastric carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1883962440492041856","@type":"Dataset","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cross-species analysis of genome-wide regulatory networks identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1038/nmeth.3440"},{"@type":"OPENAIRE","@value":"doi_dedup___::b78a1a91c1a3a220892b4d6438f94ed4"},{"@type":"CROSSREF","@value":"10.1111/pin.12493_references_DOI_6TfwTC91ClfPY8UVXxmFoH5N6wp"}]}