{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699995586491776.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/s41467-020-15420-8"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41467-020-15420-8.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41467-020-15420-8"}}],"dc:title":[{"@value":"Nitric oxide as a source for bacterial triazole biosynthesis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>The heterocycle 1,2,3-triazole is among the most versatile chemical scaffolds and has been widely used in diverse fields. However, how nature creates this nitrogen-rich ring system remains unknown. Here, we report the biosynthetic route to the triazole-bearing antimetabolite 8-azaguanine. We reveal that its triazole moiety can be assembled through an enzymatic and non-enzymatic cascade, in which nitric oxide is used as a building block. These results expand our knowledge of the physiological role of nitric oxide synthase in building natural products with a nitrogen–nitrogen bond, and should also inspire the development of synthetic biology approaches for triazole production.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699995586491778","@type":"Researcher","foaf:name":[{"@value":"Guiyun Zhao"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995586491781","@type":"Researcher","foaf:name":[{"@value":"Yuan-Yang Guo"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995586491776","@type":"Researcher","foaf:name":[{"@value":"Shunyu Yao"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995586491777","@type":"Researcher","foaf:name":[{"@value":"Xinjie Shi"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995586491780","@type":"Researcher","foaf:name":[{"@value":"Longxian Lv"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995586491779","@type":"Researcher","foaf:name":[{"@value":"Yi-Ling Du"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20411723"}],"prism:publicationName":[{"@value":"Nature Communications"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2020-03-31","prism:volume":"11","prism:number":"1","prism:startingPage":"1614"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/s41467-020-15420-8.pdf"},{"@id":"https://www.nature.com/articles/s41467-020-15420-8"}],"createdAt":"2020-03-31","modifiedAt":"2022-12-05","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050573243718038528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"1,2,3-Triazine formation mechanism of the fairy chemical 2-azahypoxanthine in the fairy ring-forming fungus Lepista sordida"},{"@value":"1,2,3-Triazine formation mechanism of the fairy chemical 2-azahypoxanthine in the fairy ring-forming fungus <i>Lepista sordida</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021390738888704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Carrier Protein Mediated Formation of the Dihydropyridazinone Ring in Actinopyridazinone Biosynthesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232152435456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Identification of Biosynthetic and Metabolic Genes of 2-Azahypoxanthine in <i>Lepista sordida</i> Based on Transcriptomic Analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707357059584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A Natural Dihydropyridazinone Scaffold Generated from a Unique Substrate for a Hydrazine-Forming Enzyme"}]},{"@id":"https://cir.nii.ac.jp/crid/1390287907269712384","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Engineered Biosynthesis of Pharmaceutically Important Compounds"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1038/s41467-020-15420-8"},{"@type":"CROSSREF","@value":"10.1002/anie.202305155_references_DOI_EGtG6v4giT2Txl1ZVtCAj6tjVg6"},{"@type":"CROSSREF","@value":"10.1248/cpb.c21-00032_references_DOI_EGtG6v4giT2Txl1ZVtCAj6tjVg6"},{"@type":"CROSSREF","@value":"10.1039/d2ob00328g_references_DOI_EGtG6v4giT2Txl1ZVtCAj6tjVg6"},{"@type":"CROSSREF","@value":"10.1021/acs.jnatprod.2c00789_references_DOI_EGtG6v4giT2Txl1ZVtCAj6tjVg6"},{"@type":"CROSSREF","@value":"10.1021/jacs.2c05269_references_DOI_EGtG6v4giT2Txl1ZVtCAj6tjVg6"}]}