{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699995657500800.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1128/mcb.25.23.10528-10532.2005"}},{"identifier":{"@type":"URI","@value":"https://journals.asm.org/doi/pdf/10.1128/MCB.25.23.10528-10532.2005"}},{"identifier":{"@type":"URI","@value":"https://www.tandfonline.com/doi/pdf/10.1128/MCB.25.23.10528-10532.2005"}},{"identifier":{"@type":"PMID","@value":"16287864"}},{"identifier":{"@type":"NAID","@value":"30021004243"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"<i>PSF1</i> Is Essential for Early Embryogenesis in Mice"},{"@language":"en","@value":"PSF1 is essential for early embryogenesis in mice."}],"description":[{"notation":[{"@value":"Psf1 (partner of sld five 1) forms a novel heterotetramer complex, GINS (Go, Ichi, Nii, and San; five, one, two, and three, respectively, in Japanese), with Sld5, Psf2, and Psf3. The formation of this complex is essential for the initiation of DNA replication in yeast and Xenopus laevis egg extracts. Although all of the components are well conserved in higher eukaryotes, the biological function in vivo is largely unknown. We originally cloned the mouse ortholog of PSF1 from a hematopoietic stem cell cDNA library and found that PSF1 is expressed in blastocysts, adult bone marrow, and testis, in which the stem cell system is active. Here we used the gene-targeting technique to determine the physiological function of PSF1 in vivo. Mice homozygous for a nonfunctional mutant of PSF1 died in utero around the time of implantation. PSF1-/- blastocysts failed to show outgrowth in culture and exhibited a cell proliferation defect. Our data clearly indicate that PSF1 is required for early embryogenesis."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326229336192","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20334766"},{"@type":"NRID","@value":"1000020334766"},{"@type":"NRID","@value":"9000242448251"},{"@type":"NRID","@value":"9000002847501"},{"@type":"NRID","@value":"9000411031724"},{"@type":"NRID","@value":"9000014275521"},{"@type":"NRID","@value":"9000000190914"},{"@type":"NRID","@value":"9000023534088"},{"@type":"NRID","@value":"9000253178594"},{"@type":"NRID","@value":"9000001901123"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0054009"}],"foaf:name":[{"@value":"Masaya Ueno"}],"jpcoar:affiliationName":[{"@value":"Department of Stem Cell Biology, Cancer Research Institute, Kanazawa University"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995657500805","@type":"Researcher","foaf:name":[{"@value":"Machiko 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Takakura"}],"jpcoar:affiliationName":[{"@value":"Department of Stem Cell Biology, Cancer Research Institute, Kanazawa University"},{"@value":"PRESTO, Japan Science Technology Agency, Saitama, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"10985549"},{"@type":"PISSN","@value":"02707306"}],"prism:publicationName":[{"@value":"Molecular and Cellular Biology"}],"dc:publisher":[{"@value":"Informa UK Limited"}],"prism:publicationDate":"2005-12-01","prism:volume":"25","prism:number":"23","prism:startingPage":"10528","prism:endingPage":"10532"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://journals.asm.org/non-commercial-tdm-license"],"url":[{"@id":"https://journals.asm.org/doi/pdf/10.1128/MCB.25.23.10528-10532.2005"},{"@id":"https://www.tandfonline.com/doi/pdf/10.1128/MCB.25.23.10528-10532.2005"}],"createdAt":"2005-11-15","modifiedAt":"2023-03-28","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Knockout","dc:title":"Mice, Knockout"},{"@id":"https://cir.nii.ac.jp/all?q=Genes,%20Essential","dc:title":"Genes, Essential"},{"@id":"https://cir.nii.ac.jp/all?q=Time%20Factors","dc:title":"Time Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Embryonic%20Development","dc:title":"Embryonic Development"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation,%20Developmental","dc:title":"Gene Expression Regulation, Developmental"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Blastocyst","dc:title":"Blastocyst"},{"@id":"https://cir.nii.ac.jp/all?q=Embryo%20Loss","dc:title":"Embryo Loss"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=ATP-Binding%20Cassette%20Transporters","dc:title":"ATP-Binding Cassette Transporters"},{"@id":"https://cir.nii.ac.jp/all?q=ATP%20Binding%20Cassette%20Transporter,%20Subfamily%20B,%20Member%202","dc:title":"ATP Binding Cassette Transporter, Subfamily B, Member 2"},{"@id":"https://cir.nii.ac.jp/all?q=Cloning,%20Molecular","dc:title":"Cloning, Molecular"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Deletion","dc:title":"Gene Deletion"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Proliferation","dc:title":"Cell Proliferation"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002215789900800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Possible Role of Mural Cell–Covered Mature Blood Vessels in Inducing Drug Resistance in Cancer-Initiating Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002219096255616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"PSF1 (Partner of SLD Five 1) is a Prognostic Biomarker in Patients with Non-small Cell Lung Cancer Treated with Surgery Following Preoperative Chemotherapy or Chemoradiotherapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002219432684032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Requirement of SLD5 for Early 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