{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699995670709248.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1186/2191-0855-3-71"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/content/pdf/10.1186/2191-0855-3-71.pdf"}}],"dc:title":[{"@value":"Evaluation of culture media for the production of secondary metabolites in a natural products screening program"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n          <jats:p>Variation in the growing environment can have significant impacts on the quantity and diversity of fungal secondary metabolites. In the industrial setting, optimization of growing conditions can lead to significantly increased production of a compound of interest. Such optimization becomes challenging in a drug-discovery screening situation, as the ideal conditions for one organism may induce poor metabolic diversity for a different organism. Here, the impact of different media types, including six liquid media and five solid media, on the secondary metabolite production of three fungal strains was examined in the context of the drug-discovery screening process. The relative production of marker compounds was used to evaluate the usefulness and reliability of each medium for the purpose of producing secondary metabolites.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699995670709251","@type":"Researcher","foaf:name":[{"@value":"Karen M VanderMolen"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995670709248","@type":"Researcher","foaf:name":[{"@value":"Huzefa A Raja"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995670709250","@type":"Researcher","foaf:name":[{"@value":"Tamam El-Elimat"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995670709249","@type":"Researcher","foaf:name":[{"@value":"Nicholas H Oberlies"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"21910855"}],"prism:publicationName":[{"@value":"AMB Express"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2013-12","prism:volume":"3","prism:number":"1","prism:startingPage":"71"},"reviewed":"false","url":[{"@id":"https://link.springer.com/content/pdf/10.1186/2191-0855-3-71.pdf"}],"createdAt":"2013-12-17","modifiedAt":"2021-09-02","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360565170740574976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Minutisphaerales (Dothideomycetes, Ascomycota): a new order of freshwater ascomycetes including a new family, Minutisphaeraceae, and two new species from North Carolina, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/2051433317038776192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Isolation, identification, and DFT-based conformational analysis of sesquikarahanadienone and its congeners from freshwater Dothideomycetes Neohelicascus aquaticus KT4120"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1186/2191-0855-3-71"},{"@type":"CROSSREF","@value":"10.1246/bcsj.20220063_references_DOI_OWbYyGfJFOFq26iywxvIVS4n7Z"},{"@type":"CROSSREF","@value":"10.3852/15-013_references_DOI_OWbYyGfJFOFq26iywxvIVS4n7Z"}]}