{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699995693329408.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/adsc.201500965"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fadsc.201500965"}},{"identifier":{"@type":"URI","@value":"https://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.201500965"}}],"dc:title":[{"@value":"Copper‐Catalyzed Divergent Trifluoromethylation/Cyclization of Unactivated Alkenes"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Most of the precedent copper‐catalyzed trifluoromethylation reactions of unactivated alkenes concern terminal alkenes, and these processes are terminated in elimination, or nucleophilic addition, or semipinacol rearrangement, or CH bond functionalization steps. In this study, we develop a trifluoromethylation method for both unactivated terminal and internal alkenes to enable divergent late‐stage radical cyclization and achieve high molecular complexity. These cyclizations are well consistent with Baldwin’s rule. Furthermore, a kinetic isotope effect (KIE) study and control reactions were conducted, and a plausible mechanism is proposed.</jats:p><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" mimetype=\"image/gif\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic/mcontent.gif\"><jats:alt-text>magnified image</jats:alt-text></jats:graphic></jats:boxed-text></jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699995693329409","@type":"Researcher","foaf:name":[{"@value":"Jing Zheng"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995693329410","@type":"Researcher","foaf:name":[{"@value":"Ziyang Deng"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995693329411","@type":"Researcher","foaf:name":[{"@value":"Yan Zhang"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995693329408","@type":"Researcher","foaf:name":[{"@value":"Sunliang Cui"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"16154150"},{"@type":"EISSN","@value":"16154169"}],"prism:publicationName":[{"@value":"Advanced Synthesis & Catalysis"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2016-02-11","prism:volume":"358","prism:number":"5","prism:startingPage":"746","prism:endingPage":"751"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fadsc.201500965"},{"@id":"https://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.201500965"}],"createdAt":"2016-02-11","modifiedAt":"2025-10-06","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004233131099904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<i>N</i>-Heterocycle-Forming Amino/Carboperfluoroalkylations of Aminoalkenes by Using Perfluoro Acid Anhydrides: Mechanistic Studies and Applications Directed Toward Perfluoroalkylated Compound Libraries"}]},{"@id":"https://cir.nii.ac.jp/crid/2050588892096788096","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Fluoroalkylation methods for synthesizing versatile building blocks"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/adsc.201500965"},{"@type":"CROSSREF","@value":"10.1246/bcsj.20190080_references_DOI_G2uTr2fRFhU48Yrymn4yNvkN415"},{"@type":"CROSSREF","@value":"10.1021/acs.joc.7b02307_references_DOI_G2uTr2fRFhU48Yrymn4yNvkN415"}]}