{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699995700484096.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/em.21824"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fem.21824"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/em.21824"}}],"dc:title":[{"@value":"Acetaldehyde and the genome: Beyond nuclear DNA adducts and carcinogenesis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The designation of acetaldehyde associated with the consumption of alcoholic beverages as “carcinogenic to humans” (Group 1) by the International Agency for Research on Cancer (IARC) has brought renewed attention to the biological effects of acetaldehyde, as the primary oxidative metabolite of alcohol. Therefore, the overall focus of this review is on acetaldehyde and its direct and indirect effects on the nuclear and mitochondrial genome. We first consider different acetaldehyde‐DNA adducts, including a critical assessment of the evidence supporting a role for acetaldehyde‐DNA adducts in alcohol related carcinogenesis, and consideration of additional data needed to make a conclusion. We also review recent data on the role of the Fanconi anemia DNA repair pathway in protecting against acetaldehyde genotoxicity and carcinogenicity, as well as teratogenicity. We also review evidence from the older literature that acetaldehyde may impact the genome indirectly, via the formation of adducts with proteins that are themselves critically involved in the maintenance of genetic and epigenetic stability. Finally, we note the lack of information regarding acetaldehyde effects on the mitochondrial genome, which is notable since aldehyde dehydrogenase 2 (ALDH2), the primary acetaldehyde metabolic enzyme, is located in the mitochondrion, and roughly 30% of East Asian individuals are deficient in ALDH2 activity due to a genetic variant in the ALDH2 gene. In summary, a comprehensive understanding of all of the mechanisms by which acetaldehyde impacts the function of the genome has implications not only for alcohol and cancer, but types of alcohol related pathologies as well. Environ. Mol. Mutagen. 55:77–91, 2014. © 2013 Wiley Periodicals, Inc.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699995700484096","@type":"Researcher","foaf:name":[{"@value":"Philip J. Brooks"}],"jpcoar:affiliationName":[{"@value":"Division of Metabolism and Health Effects National Institute on Alcohol Abuse and Alcoholism Bethesda Maryland"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995700484097","@type":"Researcher","foaf:name":[{"@value":"Samir Zakhari"}],"jpcoar:affiliationName":[{"@value":"Division of Metabolism and Health Effects National Institute on Alcohol Abuse and Alcoholism Bethesda Maryland"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"08936692"},{"@type":"EISSN","@value":"10982280"}],"prism:publicationName":[{"@value":"Environmental and Molecular Mutagenesis"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2013-11-27","prism:volume":"55","prism:number":"2","prism:startingPage":"77","prism:endingPage":"91"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fem.21824"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/em.21824"}],"createdAt":"2013-11-27","modifiedAt":"2023-10-06","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050282810815032448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Recent Advances from Basic and Clinical Studies of Esophageal Squamous Cell Carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1050282810839674880","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Molecular 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alcohol consumption, and the risk of gastric cancer: the Japan Public Health Center-based prospective study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092608368896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Detection of an alcohol-associated cancer marker by single-molecule quantum sequencing"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848659208197504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Genetic controls of DNA damage avoidance in response to acetaldehyde in fission yeast"}]},{"@id":"https://cir.nii.ac.jp/crid/1361412894365925632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Protective effects of Alda-1, an ALDH2 activator, on alcohol-derived DNA damage in the esophagus of human ALDH2*2 (Glu504Lys) knock-in 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