{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699995795144448.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1080/000164800750000496"}},{"identifier":{"@type":"URI","@value":"http://www.tandfonline.com/doi/pdf/10.1080/000164800750000496"}},{"identifier":{"@type":"PMID","@value":"11039878"}},{"identifier":{"@type":"NAID","@value":"30016587796"}}],"dc:title":[{"@value":"Production of Interferon-<i>?</i>by Tonsillar Mononuclear Cells in IgA Nephropathy Patients"}],"description":[{"notation":[{"@value":"Much evidence, both in vivo and in vitro, suggests that patients with IgA nephropathy (IgAN) have enhanced IgA production. We hypothesized that Haemophilus parainfluenzae (HP) in the tonsil plays an important role in the IgA production of IgAN patients. In this study, we focused on interferon-gamma (IFN-gamma) and IgA production by tonsillar mononuclear cells (TMC) in patients with IgAN. Tonsillectomies were performed in patients with IgAN and chronic tonsillitis (CT). The induction of IFN-gamma and IgA in vitro by TMC from IgAN patients was compared with that from CT patients. In addition, we investigated whether stimulation with the outer membranes of HP (OMHP) enhanced IFN-gamma and IgA induction by TMC from patients with IgAN. Spontaneous IFN-gamma production and spontaneous total IgA production by TMC were higher in IgAN patients than in those patients with CT (p0.05). IFN-gamma induction by OMHP stimulation was also higher in IgAN patients than in CT patients. The stimulation of OMHP enhanced HP-specific IgA in IgAN but had no influence on the production of IFN-gamma in patients with either IgAN or CT compared with spontaneous IFN-gamma production. IFN-gamma production was positively correlated with total IgA values in both IgAN and CT patients, but not with HP-specific IgA. These results suggest that increased IFN-gamma production in patients with IgAN is not associated with HP infection but may play a role in the pathogenesis of IgAN."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699995795144448","@type":"Researcher","foaf:name":[{"@value":"Shigeharu Fujieda"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00016489"},{"@type":"EISSN","@value":"16512251"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00016489"}],"prism:publicationName":[{"@value":"Acta Oto-Laryngologica"}],"dc:publisher":[{"@value":"Informa UK Limited"}],"prism:publicationDate":"2000-01","prism:volume":"120","prism:number":"5","prism:startingPage":"649","prism:endingPage":"654"},"reviewed":"false","url":[{"@id":"http://www.tandfonline.com/doi/pdf/10.1080/000164800750000496"}],"createdAt":"2002-07-26","modifiedAt":"2024-01-04","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Haemophilus%20Infections","dc:title":"Haemophilus Infections"},{"@id":"https://cir.nii.ac.jp/all?q=Adolescent","dc:title":"Adolescent"},{"@id":"https://cir.nii.ac.jp/all?q=Enzyme-Linked%20Immunosorbent%20Assay","dc:title":"Enzyme-Linked Immunosorbent Assay"},{"@id":"https://cir.nii.ac.jp/all?q=Glomerulonephritis,%20IGA","dc:title":"Glomerulonephritis, IGA"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Immunoglobulin%20A","dc:title":"Immunoglobulin A"},{"@id":"https://cir.nii.ac.jp/all?q=Interferon-gamma","dc:title":"Interferon-gamma"},{"@id":"https://cir.nii.ac.jp/all?q=Tonsillitis","dc:title":"Tonsillitis"},{"@id":"https://cir.nii.ac.jp/all?q=Adenoids","dc:title":"Adenoids"},{"@id":"https://cir.nii.ac.jp/all?q=Chronic%20Disease","dc:title":"Chronic Disease"},{"@id":"https://cir.nii.ac.jp/all?q=Leukocytes,%20Mononuclear","dc:title":"Leukocytes, Mononuclear"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Child","dc:title":"Child"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004230135489792","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Recent advances in the immunological understanding of association between tonsil and immunoglobulin A nephropathy as a tonsil‐induced autoimmune/inflammatory syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1361412891608424960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A proliferation-inducing ligand (APRIL) induced hyper-production of IgA from tonsillar mononuclear cells in patients with IgA nephropathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205007133568","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Therapeutic Effects and Prognostic Factors in Tonsillectomy Patients with IgA Nephropathy"},{"@language":"ja","@value":"ＩｇＡ腎症に対する扁桃摘出術の臨床効果と予後予測因子の検討"},{"@language":"ja-Kana","@value":"IgAジンショウ ニ タイスル ヘントウ テキシュツジュツ ノ リンショウ コウカ ト ヨゴ ヨソク インシ ノ ケントウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205011841024","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"耳鼻咽喉科とＴｒａｎｓｌａｔｉｏｎａｌ　Ｒｅｓｅａｒｃｈ―扁桃を病巣としたＩｇＡ腎症の発症機序の解明―"},{"@value":"第110回日本耳鼻咽喉科学会シンポジウム 耳鼻咽喉科とTranslational Research--扁桃を病巣としたIgA腎症の発症機序の解明"},{"@language":"ja-Kana","@value":"ダイ110カイ ニホン ジビ インコウ カガッカイ シンポジウム ジビ インコウカ ト Translational Research ヘントウ オ ビョウソウ ト シタ IgAジンショウ ノ ハッショウ キジョ ノ カイメイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854175410197504","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"口蓋扁桃組織における抗菌ペプチド defensin の発現"},{"@language":"en","@value":"Expression profile of human defensins in tonsils"}]},{"@id":"https://cir.nii.ac.jp/crid/2051433317031836800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Intravenous administration of Streptococcus mutans induces IgA nephropathy-like lesions"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1080/000164800750000496"},{"@type":"CIA","@value":"30016587796"},{"@type":"OPENAIRE","@value":"doi_dedup___::6c51c259dcc6d41bb8bea65c3266ec44"},{"@type":"CROSSREF","@value":"10.1002/iid3.248_references_DOI_5ftsSXHErDRwKiirq8hO4wZNDpY"},{"@type":"CROSSREF","@value":"10.3950/jibiinkoka.110.53_references_DOI_5ftsSXHErDRwKiirq8hO4wZNDpY"},{"@type":"CROSSREF","@value":"10.3950/jibiinkoka.112.689_references_DOI_5ftsSXHErDRwKiirq8hO4wZNDpY"},{"@type":"CROSSREF","@value":"10.1007/s10157-020-01961-1_references_DOI_5ftsSXHErDRwKiirq8hO4wZNDpY"},{"@type":"CROSSREF","@value":"10.1016/j.cellimm.2019.103925_references_DOI_5ftsSXHErDRwKiirq8hO4wZNDpY"}]}