{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699995808074752.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1097/meg.0000000000000989"}},{"identifier":{"@type":"URI","@value":"https://journals.lww.com/00042737-201801000-00014"}}],"dc:title":[{"@value":"Gut colonization with extended-spectrum β-lactamase-producing Enterobacteriaceae may increase disease activity in biologic-naive outpatients with ulcerative colitis: an interim analysis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec>\n            <jats:title>Background</jats:title>\n            <jats:p>Certain <jats:italic toggle=\"yes\">Enterobacteriaceae</jats:italic> strains have been associated with the development of ulcerative colitis (UC). Extended-spectrum β-lactamase (ESBL)-producing <jats:italic toggle=\"yes\">Enterobacteriaceae</jats:italic> are the most commonly found multi-drug-resistant (MDR) bacteria colonizing the gut in UC patients and might trigger a more severe disease activity in UC patients.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Objective</jats:title>\n            <jats:p>The aim of this study was to evaluate whether disease activity is higher in UC patients with gut colonization with ESBL-producing <jats:italic toggle=\"yes\">Enterobacteriaceae</jats:italic>.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Materials and methods</jats:title>\n            <jats:p>A cross-sectional, pilot study was carried out in a tertiary medical center in Latvia. Demographic data were collected; UC disease activity and extent were evaluated according to the full Mayo score, Montreal classification, and adapted Truelove and Witt’s index. Rectal swabs with fecal biomaterial were collected, ESBL-producing <jats:italic toggle=\"yes\">Enterobacteriaceae</jats:italic> were isolated, and bacterial plasmid genes responsible for ESBL production, <jats:italic toggle=\"yes\">blaCTX-M</jats:italic>, <jats:italic toggle=\"yes\">blaTEM</jats:italic>, and <jats:italic toggle=\"yes\">blaSHV</jats:italic>, were detected. UC disease activity was compared in patients with and without gut colonization with ESBL-producing <jats:italic toggle=\"yes\">Enterobacteriaceae.</jats:italic>\n                              </jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Results</jats:title>\n            <jats:p>A total of 65 patients with UC were included in the initial analysis. Gut colonization with ESBL-producing <jats:italic toggle=\"yes\">Enterobacteriaceae</jats:italic> was found in seven (11%) patients – mostly <jats:italic toggle=\"yes\">Escherichia coli</jats:italic> [5 (71%)] containing the <jats:italic toggle=\"yes\">blaCTX-M</jats:italic> bacterial plasmid gene. Patients with gut colonization with ESBL-producing <jats:italic toggle=\"yes\">Enterobacteriaceae</jats:italic> had more severe disease compared with patients without gut colonization according to the full Mayo score (5.86 vs. 3.40; <jats:italic toggle=\"yes\">P</jats:italic>=0.015), Montreal classification (moderate disease vs. clinical remission; <jats:italic toggle=\"yes\">P</jats:italic>=0.031), and adapted Truelove and Witt’s index (moderate disease vs. mild disease; <jats:italic toggle=\"yes\">P</jats:italic>=0.008).</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion</jats:title>\n            <jats:p>Gut colonization with ESBL-producing <jats:italic toggle=\"yes\">Enterobacteriaceae</jats:italic> may increase UC disease activity. Further research is needed to analyze the possible confounding factors that could contribute toward this outcome.</jats:p>\n          </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699995808074625","@type":"Researcher","foaf:name":[{"@value":"Vita Skuja"}],"jpcoar:affiliationName":[{"@value":"Department of Internal Medicine"},{"@value":"Department of Gastroenterology, Hepatology and Nutrition, Gastroenterology, Hepatology and Nutrition Clinic"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995808074629","@type":"Researcher","foaf:name":[{"@value":"Aleksejs Derovs"}],"jpcoar:affiliationName":[{"@value":"Department of Internal Medicine"},{"@value":"Department of Infectology and Dermatology"},{"@value":"Department of Gastroenterology, Hepatology and Nutrition, Gastroenterology, Hepatology and Nutrition Clinic"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995808074632","@type":"Researcher","foaf:name":[{"@value":"Katrina Pekarska"}],"jpcoar:affiliationName":[{"@value":"Department of Internal Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995808074627","@type":"Researcher","foaf:name":[{"@value":"Dace Rudzite"}],"jpcoar:affiliationName":[{"@value":"Department of Microbiology, Laboratory Medicine Centre"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995808074626","@type":"Researcher","foaf:name":[{"@value":"Elvira Lavrinovica"}],"jpcoar:affiliationName":[{"@value":"Department of Microbiology, Laboratory Medicine Centre"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995808074633","@type":"Researcher","foaf:name":[{"@value":"Linda Piekuse"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Genetics, Scientific Laboratory of Molecular Genetics"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995808074628","@type":"Researcher","foaf:name":[{"@value":"Inga Kempa"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Genetics, Scientific Laboratory of Molecular Genetics"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995808074630","@type":"Researcher","foaf:name":[{"@value":"Zane Straume"}],"jpcoar:affiliationName":[{"@value":"Department of Internal Medicine"},{"@value":"Department of Gastroenterology, Hepatology and Nutrition, Gastroenterology, Hepatology and Nutrition Clinic"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995808074624","@type":"Researcher","foaf:name":[{"@value":"Jelena Eglite"}],"jpcoar:affiliationName":[{"@value":"Department of Clinical Immunology and Immunogenetics, Laboratory of Clinical Immunology and Immunogenetics Scientific Centre ‘Kleisti’, Riga Stradins University"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995808074631","@type":"Researcher","foaf:name":[{"@value":"Aivars Lejnieks"}],"jpcoar:affiliationName":[{"@value":"Department of Internal Medicine"},{"@value":"Department of Internal Medicine, Riga East Clinical University Hospital, Riga, Latvia"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995808074634","@type":"Researcher","foaf:name":[{"@value":"Angelika Krumina"}],"jpcoar:affiliationName":[{"@value":"Department of Infectology and Dermatology"},{"@value":"Department of Infectology"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995808074752","@type":"Researcher","foaf:name":[{"@value":"Rami Eliakim"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology, Sackler School of Medicine, Sheba Medical Center, Tel-Aviv University, Israel"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0954691X"}],"prism:publicationName":[{"@value":"European Journal of Gastroenterology & Hepatology"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2018-01","prism:volume":"30","prism:number":"1","prism:startingPage":"92","prism:endingPage":"100"},"reviewed":"false","url":[{"@id":"https://journals.lww.com/00042737-201801000-00014"}],"createdAt":"2017-10-25","modifiedAt":"2023-09-16","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1362257542314102016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Association of colitis with gut-microbiota dysbiosis in clathrin adapter AP-1B knockout mice"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1097/meg.0000000000000989"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0228358_references_DOI_OSDLILhqZKuwYVmCOsiDBBiqGKu"}]}