{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699995860083200.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/em.10131"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fem.10131"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/em.10131"}}],"dc:title":[{"@value":"Treatment and sampling protocols for transgenic mutation assays"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>The standard protocol for testing chemicals with the transgenic mutation assays in vivo includes a period of time between treatment and sampling to permit the mutation frequency to reach a maximum. Recent evidence has shown, however, that for some chemicals the mutant frequency can decline substantially during this period, which would reduce the sensitivity of the assay. Here we discuss alternate protocols to maintain the sensitivity of the assay for both types of mutagens and, in particular, propose that treatments should continue until the time of sampling. Environ. Mol. Mutagen. 41:1–6, 2003. © 2003 Wiley‐Liss, Inc.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699995860083201","@type":"Researcher","foaf:name":[{"@value":"John A. Heddle"}]},{"@id":"https://cir.nii.ac.jp/crid/1380579929776556416","@type":"Researcher","foaf:name":[{"@value":"Hans‐Joerg Martus"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995860083202","@type":"Researcher","foaf:name":[{"@value":"George R. Douglas"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"08936692"},{"@type":"EISSN","@value":"10982280"}],"prism:publicationName":[{"@value":"Environmental and Molecular Mutagenesis"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2003-01","prism:volume":"41","prism:number":"1","prism:startingPage":"1","prism:endingPage":"6"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fem.10131"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/em.10131"}],"createdAt":"2003-01-28","modifiedAt":"2023-11-17","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390282680234625152","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Exposure to Ethylating Agents: Where Do the Thresholds for Mutagenic/Clastogenic Effects Arise?"}]},{"@id":"https://cir.nii.ac.jp/crid/2050307416982128768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Genomic integration of lambda EG10 transgene in gpt delta transgenic rodents"}]},{"@id":"https://cir.nii.ac.jp/crid/2050307417128021760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"New homozygous gpt delta transgenic rat strain improves an efficiency of the in vivo mutagenicity assay"}]},{"@id":"https://cir.nii.ac.jp/crid/2050588891958842112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Estimation of the frequency of inherited germline mutations by whole exome sequencing in ethyl nitrosourea-treated and untreated gpt delta mice"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/em.10131"},{"@type":"CROSSREF","@value":"10.1186/s41021-015-0024-6_references_DOI_K7aoLW0IWCMEMNTe8ndTcZc47Ox"},{"@type":"CROSSREF","@value":"10.1186/s41021-016-0035-y_references_DOI_K7aoLW0IWCMEMNTe8ndTcZc47Ox"},{"@type":"CROSSREF","@value":"10.3123/jemsge.34.171_references_DOI_K7aoLW0IWCMEMNTe8ndTcZc47Ox"},{"@type":"CROSSREF","@value":"10.1186/s41021-021-00195-1_references_DOI_K7aoLW0IWCMEMNTe8ndTcZc47Ox"}]}