{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699995957507712.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1128/jvi.00871-13"}},{"identifier":{"@type":"URI","@value":"https://journals.asm.org/doi/pdf/10.1128/JVI.00871-13"}}],"dc:title":[{"@value":"High-Avidity and Potently Neutralizing Cross-Reactive Human Monoclonal Antibodies Derived from Secondary Dengue Virus Infection"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>The envelope (E) protein of dengue virus (DENV) is the major target of neutralizing antibodies (Abs) and vaccine development. Previous studies of human dengue-immune sera reported that a significant proportion of anti-E Abs, known as group-reactive (GR) Abs, were cross-reactive to all four DENV serotypes and to one or more other flaviviruses. Based on studies of mouse anti-E monoclonal antibodies (MAbs), GR MAbs were nonneutralizing or weakly neutralizing compared with type-specific MAbs; a GR response was thus not regarded as important for vaccine strategy. We investigated the epitopes, binding avidities, and neutralization potencies of 32 human GR anti-E MAbs. In addition to fusion loop (FL) residues in E protein domain II, human GR MAbs recognized an epitope involving both FL and bc loop residues in domain II. The neutralization potencies and binding avidities of GR MAbs derived from secondary DENV infection were stronger than those derived from primary infection. GR MAbs derived from primary DENV infection primarily blocked attachment, whereas those derived from secondary infection blocked DENV postattachment. Analysis of the repertoire of anti-E MAbs derived from patients with primary DENV infection revealed that the majority were GR, low-avidity, and weakly neutralizing MAbs, whereas those from secondary infection were primarily GR, high-avidity, and potently neutralizing MAbs. Our findings suggest that the weakly neutralizing GR anti-E Abs generated from primary DENV infection become potently neutralizing MAbs against the four serotypes after secondary infection. The observation that the dengue immune status of the host affects the quality of the cross-reactive Abs generated has implications for new strategies for DENV vaccination.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699995957507712","@type":"Researcher","foaf:name":[{"@value":"Wen-Yang Tsai"}],"jpcoar:affiliationName":[{"@value":"Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995957507586","@type":"Researcher","foaf:name":[{"@value":"Chih-Yun Lai"}],"jpcoar:affiliationName":[{"@value":"Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995957507716","@type":"Researcher","foaf:name":[{"@value":"Yi-Chieh Wu"}],"jpcoar:affiliationName":[{"@value":"Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995957507717","@type":"Researcher","foaf:name":[{"@value":"Hong-En Lin"}],"jpcoar:affiliationName":[{"@value":"Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995957507714","@type":"Researcher","foaf:name":[{"@value":"Carolyn Edwards"}],"jpcoar:affiliationName":[{"@value":"Division of Immunology and Inflammation, Department of Medicine, Hammersmith Campus, Imperial College of London, London, United Kingdom"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995957507718","@type":"Researcher","foaf:name":[{"@value":"Amonrat Jumnainsong"}],"jpcoar:affiliationName":[{"@value":"Division of Immunology and Inflammation, Department of Medicine, Hammersmith Campus, Imperial College of London, London, United Kingdom"},{"@value":"Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995957507715","@type":"Researcher","foaf:name":[{"@value":"Srisakul Kliks"}],"jpcoar:affiliationName":[{"@value":"Pediatric Dengue Vaccine Initiative, International Vaccine Institute, Seoul, South Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995957507585","@type":"Researcher","foaf:name":[{"@value":"Scott Halstead"}],"jpcoar:affiliationName":[{"@value":"Pediatric Dengue Vaccine Initiative, International Vaccine Institute, Seoul, South Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995957507584","@type":"Researcher","foaf:name":[{"@value":"Juthathip Mongkolsapaya"}],"jpcoar:affiliationName":[{"@value":"Division of Immunology and Inflammation, Department of Medicine, Hammersmith Campus, Imperial College of London, London, United Kingdom"},{"@value":"Dengue Hemorrhagic Fever Research Unit, Office for Research and Development, Siriraj Hospital, Mahidol University, Bangkok, Thailand"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995957507713","@type":"Researcher","foaf:name":[{"@value":"Gavin R. Screaton"}],"jpcoar:affiliationName":[{"@value":"Division of Immunology and Inflammation, Department of Medicine, Hammersmith Campus, Imperial College of London, London, United Kingdom"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995957507719","@type":"Researcher","foaf:name":[{"@value":"Wei-Kung Wang"}],"jpcoar:affiliationName":[{"@value":"Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA"},{"@value":"Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0022538X"},{"@type":"EISSN","@value":"10985514"}],"prism:publicationName":[{"@value":"Journal of Virology"}],"dc:publisher":[{"@value":"American Society for Microbiology"}],"prism:publicationDate":"2013-12","prism:volume":"87","prism:number":"23","prism:startingPage":"12562","prism:endingPage":"12575"},"reviewed":"false","dc:rights":["https://journals.asm.org/non-commercial-tdm-license"],"url":[{"@id":"https://journals.asm.org/doi/pdf/10.1128/JVI.00871-13"}],"createdAt":"2013-09-12","modifiedAt":"2022-03-05","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050568772240586240","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Human antibody response to dengue virus: implications for dengue vaccine design"}]},{"@id":"https://cir.nii.ac.jp/crid/1050856995321770880","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"An affinity-matured human monoclonal antibody targeting fusion loop epitope of dengue virus with in vivo therapeutic potency"},{"@value":"An affinity-matured human monoclonal antibody targeting fusion loop epitope of dengue virus with\n                  <i>in vivo</i>\n                  therapeutic potency"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302866853972224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Development of flavivirus subviral particles with low cross-reactivity by mutations of a distinct antigenic domain"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1128/jvi.00871-13"},{"@type":"CROSSREF","@value":"10.1186/s41182-016-0004-y_references_DOI_S3vm192CSGKKAux8gTgWKziaTSJ"},{"@type":"CROSSREF","@value":"10.1101/2020.10.03.324731_references_DOI_S3vm192CSGKKAux8gTgWKziaTSJ"},{"@type":"CROSSREF","@value":"10.1038/s41598-021-92403-9_references_DOI_S3vm192CSGKKAux8gTgWKziaTSJ"},{"@type":"CROSSREF","@value":"10.1007/s00253-023-12817-5_references_DOI_S3vm192CSGKKAux8gTgWKziaTSJ"}]}