{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699995992897152.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1161/hypertensionaha.109.139964"}},{"identifier":{"@type":"URI","@value":"https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.109.139964"}}],"dc:title":[{"@value":"Wave Reflection and Arterial Stiffness in the Prediction of 15-Year All-Cause and Cardiovascular Mortalities"}],"dcterms:alternative":[{"@value":"A Community-Based Study"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n            The value of increased arterial wave reflection, usually assessed by the transit time–dependent augmentation index and augmented pressure (Pa), in the prediction of cardiovascular events may have been underestimated. We investigated whether the transit time–independent measures of reflected wave magnitude predict cardiovascular outcomes independent of arterial stiffness indexed by carotid-femoral pulse wave velocity. A total of 1272 participants (47% women; mean age: 52±13 years; range: 30 to 79 years) from a community-based survey were studied. Carotid pressure waveforms derived by tonometry were decomposed into their forward wave amplitudes, backward wave amplitudes (Pb), and a reflection index (=[Pb/(forward wave amplitude+Pb)]), in addition to augmentation index, Pa, and reflected wave transit time. During a median follow-up of 15 years, 225 deaths occurred (17.6%), including 64 cardiovascular origins (5%). In univariate Cox proportional hazard regression analysis, pulse wave velocity, Pa, and Pb predicted all-cause and cardiovascular mortality in both men and women, whereas augmentation index, reflected wave transit time, and reflection index were predictive only in men. In multivariate analysis accounting for age, height, and heart rate, Pb predicted cardiovascular mortality in both men and women, whereas Pa was predictive only in men. Per 1-SD increment (6 mm Hg), Pb predicted 15-year cardiovascular mortality independent of brachial but not central pressure, pulse wave velocity, augmentation index, Pa, and conventional cardiovascular risk factors with hazard ratios of ≈1.60 (all\n            <jats:italic>P</jats:italic>\n            <0.05). In conclusion, Pb, a transit time–independent measure of reflected wave magnitude, predicted long-term cardiovascular mortality in men and women independent of arterial stiffness.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699995992897027","@type":"Researcher","foaf:name":[{"@value":"Kang-Ling Wang"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Medicine (K.-L.W., S.-H.S., C.-H.L.) and Medical Research and Education (H.-M.C., C.-H.C.), Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Biomedical Sciences (S.-Y.C.), Academia Sinica, Taipei, Taiwan; Laboratory of Cardiovascular Science (H.A.S., S.S.N., E.G.L.), National Institute on Aging Intramural Research Program, Baltimore, Md; Cardiovascular Center (C.-T.T.), Taichung Veterans General Hospital, Taichung, Taiwan; Department of Biomedical Engineering (F..."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995992897026","@type":"Researcher","foaf:name":[{"@value":"Hao-Min Cheng"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Medicine (K.-L.W., S.-H.S., C.-H.L.) and Medical Research and Education (H.-M.C., C.-H.C.), Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Biomedical Sciences (S.-Y.C.), Academia Sinica, Taipei, Taiwan; Laboratory of Cardiovascular Science (H.A.S., S.S.N., E.G.L.), National Institute on Aging Intramural Research Program, Baltimore, Md; Cardiovascular Center (C.-T.T.), Taichung Veterans General Hospital, Taichung, Taiwan; Department of Biomedical Engineering (F..."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995992897153","@type":"Researcher","foaf:name":[{"@value":"Shih-Hsien Sung"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Medicine (K.-L.W., S.-H.S., C.-H.L.) and Medical Research and Education (H.-M.C., C.-H.C.), Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Biomedical Sciences (S.-Y.C.), Academia Sinica, Taipei, Taiwan; Laboratory of Cardiovascular Science (H.A.S., S.S.N., E.G.L.), National Institute on Aging Intramural Research Program, Baltimore, Md; Cardiovascular Center (C.-T.T.), Taichung Veterans General Hospital, Taichung, Taiwan; Department of Biomedical Engineering (F..."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995992897025","@type":"Researcher","foaf:name":[{"@value":"Shao-Yuan Chuang"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Medicine (K.-L.W., S.-H.S., C.-H.L.) and Medical Research and Education (H.-M.C., C.-H.C.), Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Biomedical Sciences (S.-Y.C.), Academia Sinica, Taipei, Taiwan; Laboratory of Cardiovascular Science (H.A.S., S.S.N., E.G.L.), National Institute on Aging Intramural Research Program, Baltimore, Md; Cardiovascular Center (C.-T.T.), Taichung Veterans General Hospital, Taichung, Taiwan; Department of Biomedical Engineering (F..."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995992897028","@type":"Researcher","foaf:name":[{"@value":"Cheng-Hung Li"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Medicine (K.-L.W., S.-H.S., C.-H.L.) and Medical Research and Education (H.-M.C., C.-H.C.), Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Biomedical Sciences (S.-Y.C.), Academia Sinica, Taipei, Taiwan; Laboratory of Cardiovascular Science (H.A.S., S.S.N., E.G.L.), National Institute on Aging Intramural Research Program, Baltimore, Md; Cardiovascular Center (C.-T.T.), Taichung Veterans General Hospital, Taichung, Taiwan; Department of Biomedical Engineering (F..."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995992897158","@type":"Researcher","foaf:name":[{"@value":"Harold A. Spurgeon"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Medicine (K.-L.W., S.-H.S., C.-H.L.) and Medical Research and Education (H.-M.C., C.-H.C.), Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Biomedical Sciences (S.-Y.C.), Academia Sinica, Taipei, Taiwan; Laboratory of Cardiovascular Science (H.A.S., S.S.N., E.G.L.), National Institute on Aging Intramural Research Program, Baltimore, Md; Cardiovascular Center (C.-T.T.), Taichung Veterans General Hospital, Taichung, Taiwan; Department of Biomedical Engineering (F..."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995992897154","@type":"Researcher","foaf:name":[{"@value":"Chih-Tai Ting"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Medicine (K.-L.W., S.-H.S., C.-H.L.) and Medical Research and Education (H.-M.C., C.-H.C.), Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Biomedical Sciences (S.-Y.C.), Academia Sinica, Taipei, Taiwan; Laboratory of Cardiovascular Science (H.A.S., S.S.N., E.G.L.), National Institute on Aging Intramural Research Program, Baltimore, Md; Cardiovascular Center (C.-T.T.), Taichung Veterans General Hospital, Taichung, Taiwan; Department of Biomedical Engineering (F..."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995992897157","@type":"Researcher","foaf:name":[{"@value":"Samer S. Najjar"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Medicine (K.-L.W., S.-H.S., C.-H.L.) and Medical Research and Education (H.-M.C., C.-H.C.), Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Biomedical Sciences (S.-Y.C.), Academia Sinica, Taipei, Taiwan; Laboratory of Cardiovascular Science (H.A.S., S.S.N., E.G.L.), National Institute on Aging Intramural Research Program, Baltimore, Md; Cardiovascular Center (C.-T.T.), Taichung Veterans General Hospital, Taichung, Taiwan; Department of Biomedical Engineering (F..."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995992897152","@type":"Researcher","foaf:name":[{"@value":"Edward G. Lakatta"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Medicine (K.-L.W., S.-H.S., C.-H.L.) and Medical Research and Education (H.-M.C., C.-H.C.), Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Biomedical Sciences (S.-Y.C.), Academia Sinica, Taipei, Taiwan; Laboratory of Cardiovascular Science (H.A.S., S.S.N., E.G.L.), National Institute on Aging Intramural Research Program, Baltimore, Md; Cardiovascular Center (C.-T.T.), Taichung Veterans General Hospital, Taichung, Taiwan; Department of Biomedical Engineering (F..."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995992897024","@type":"Researcher","foaf:name":[{"@value":"Frank C.P. Yin"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Medicine (K.-L.W., S.-H.S., C.-H.L.) and Medical Research and Education (H.-M.C., C.-H.C.), Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Biomedical Sciences (S.-Y.C.), Academia Sinica, Taipei, Taiwan; Laboratory of Cardiovascular Science (H.A.S., S.S.N., E.G.L.), National Institute on Aging Intramural Research Program, Baltimore, Md; Cardiovascular Center (C.-T.T.), Taichung Veterans General Hospital, Taichung, Taiwan; Department of Biomedical Engineering (F..."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995992897156","@type":"Researcher","foaf:name":[{"@value":"Pesus Chou"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Medicine (K.-L.W., S.-H.S., C.-H.L.) and Medical Research and Education (H.-M.C., C.-H.C.), Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Biomedical Sciences (S.-Y.C.), Academia Sinica, Taipei, Taiwan; Laboratory of Cardiovascular Science (H.A.S., S.S.N., E.G.L.), National Institute on Aging Intramural Research Program, Baltimore, Md; Cardiovascular Center (C.-T.T.), Taichung Veterans General Hospital, Taichung, Taiwan; Department of Biomedical Engineering (F..."}]},{"@id":"https://cir.nii.ac.jp/crid/1381699995992897155","@type":"Researcher","foaf:name":[{"@value":"Chen-Huan Chen"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Medicine (K.-L.W., S.-H.S., C.-H.L.) and Medical Research and Education (H.-M.C., C.-H.C.), Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Biomedical Sciences (S.-Y.C.), Academia Sinica, Taipei, Taiwan; Laboratory of Cardiovascular Science (H.A.S., S.S.N., E.G.L.), National Institute on Aging Intramural Research Program, Baltimore, Md; Cardiovascular Center (C.-T.T.), Taichung Veterans General Hospital, Taichung, Taiwan; Department of Biomedical Engineering (F..."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0194911X"},{"@type":"EISSN","@value":"15244563"}],"prism:publicationName":[{"@value":"Hypertension"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2010-03","prism:volume":"55","prism:number":"3","prism:startingPage":"799","prism:endingPage":"805"},"reviewed":"false","url":[{"@id":"https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.109.139964"}],"createdAt":"2010-01-12","modifiedAt":"2024-05-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050855224108909696","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Sex Differences in Flexibility-Arterial Stiffness Relationship and Its Application for Diagnosis of Arterial Stiffening: A Cross-Sectional Observational Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235772445056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Hemodynamic arteriosclerotic syndrome – A vicious cycle of hemodynamic stress and vascular disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285709866917120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Central diastolic pressure decay mediates the relationship between aortic stiffness and myocardial viability"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285714188746880","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Relationship of Ambulatory Blood Pressure and the Heart Rate Profile with Renal Function Parameters in Hypertensive Patients with Chronic Kidney Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185700571392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effects of Aliskiren‐Based Therapy on Ambulatory Blood Pressure Profile, Central Hemodynamics, and Arterial Stiffness in Nondiabetic Mild to Moderate Hypertensive Patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567186362576000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Evaluation of Central Blood Pressure in an Asian Population: Comparison between Brachial Oscillometry and Radial Tonometry Methods"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204431185792","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Central Hemodynamics for Management of Arteriosclerotic Diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204431989504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Add-on Therapy of EPA Reduces Oxidative Stress and Inhibits the Progression of Aortic Stiffness in Patients with Coronary Artery Disease and Statin Therapy: A Randomized Controlled Study"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1161/hypertensionaha.109.139964"},{"@type":"CROSSREF","@value":"10.1111/jch.13313_references_DOI_KyxW41tN5tJEfBRSyV8PcE2GJnu"},{"@type":"CROSSREF","@value":"10.1097/hjh.0000000000001436_references_DOI_KyxW41tN5tJEfBRSyV8PcE2GJnu"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0113646_references_DOI_KyxW41tN5tJEfBRSyV8PcE2GJnu"},{"@type":"CROSSREF","@value":"10.3109/10641963.2012.681082_references_DOI_KyxW41tN5tJEfBRSyV8PcE2GJnu"},{"@type":"CROSSREF","@value":"10.1111/j.1751-7176.2012.00640.x_references_DOI_KyxW41tN5tJEfBRSyV8PcE2GJnu"},{"@type":"CROSSREF","@value":"10.1159/000484442_references_DOI_KyxW41tN5tJEfBRSyV8PcE2GJnu"},{"@type":"CROSSREF","@value":"10.5551/jat.40717_references_DOI_KyxW41tN5tJEfBRSyV8PcE2GJnu"},{"@type":"CROSSREF","@value":"10.5551/jat.7260_references_DOI_KyxW41tN5tJEfBRSyV8PcE2GJnu"}]}