{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699996061072256.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/ncomms7582"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/ncomms7582.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/ncomms7582"}}],"dc:title":[{"@value":"Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Organometallic complexes are effective hydrogenation catalysts for organic reactions. For example, Noyori-type ruthenium complexes catalyse reduction of ketones by transfer of hydride from formate. Here we show that such catalytic reactions can be achieved in cancer cells, offering a new strategy for the design of safe metal-based anticancer drugs. The activity of ruthenium(II) sulfonamido ethyleneamine complexes towards human ovarian cancer cells is enhanced by up to 50 × in the presence of low non-toxic doses of formate. The extent of conversion of coenzyme NAD<jats:sup>+</jats:sup> to NADH in cells is dependent on formate concentration. This novel reductive stress mechanism of cell death does not involve apoptosis or perturbation of mitochondrial membrane potentials. In contrast, iridium cyclopentadienyl catalysts cause cancer cell death by oxidative stress. Organometallic complexes therefore have an extraordinary ability to modulate the redox status of cancer cells.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699996061072258","@type":"Researcher","foaf:name":[{"@value":"Joan J. Soldevila-Barreda"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699996061072256","@type":"Researcher","foaf:name":[{"@value":"Isolda Romero-Canelón"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699996061072257","@type":"Researcher","foaf:name":[{"@value":"Abraha Habtemariam"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699996061072128","@type":"Researcher","foaf:name":[{"@value":"Peter J. Sadler"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20411723"}],"prism:publicationName":[{"@value":"Nature Communications"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2015-03-20","prism:volume":"6","prism:number":"1","prism:startingPage":"6582"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/ncomms7582.pdf"},{"@id":"https://www.nature.com/articles/ncomms7582"}],"createdAt":"2015-03-20","modifiedAt":"2023-01-05","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360846640964663808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Aminolysis of [Cp*Ru(μ-OEt)]2 (Cp* = η5-C5Me5) with sulfonamides: Synthesis of neutral, zwitterionic, and anionic Cp*Ru terminal sulfonamido complexes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567791404800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Ligand-Directed Approach to Activity-Based Sensing: Developing Palladacycle Fluorescent Probes That Enable Endogenous Carbon Monoxide Detection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869854343220608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"2-Nitroimidazole-Functionalized Superparamagnetic Iron Oxide Nanoparticles Detect Hypoxic Regions of Glioblastomas on MRI and Improve Radiotherapy Efficacy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361975842821561984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cell-Membrane Permeable Redox Phospholipid Polymers Induce Apoptosis in MDA-MB-231 Human Breast Cancer Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1390010292714336896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Anticancer luminescent gold quantum clusters for in situ cancer-selective marking-imaging-targeting."}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1038/ncomms7582"},{"@type":"CROSSREF","@value":"10.1016/j.jorganchem.2016.02.029_references_DOI_LcN11Zfk8jnjZDXaTMwfwcc7WE6"},{"@type":"CROSSREF","@value":"10.1021/acs.biomac.9b01184_references_DOI_LcN11Zfk8jnjZDXaTMwfwcc7WE6"},{"@type":"CROSSREF","@value":"10.1021/jacs.0c06405_references_DOI_LcN11Zfk8jnjZDXaTMwfwcc7WE6"},{"@type":"CROSSREF","@value":"10.1039/c7nr02229h_references_DOI_LcN11Zfk8jnjZDXaTMwfwcc7WE6"},{"@type":"CROSSREF","@value":"10.1021/acsnano.4c06753_references_DOI_LcN11Zfk8jnjZDXaTMwfwcc7WE6"}]}