{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699996205514240.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1007/s00535-012-0736-3"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/content/pdf/10.1007/s00535-012-0736-3.pdf"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/article/10.1007/s00535-012-0736-3/fulltext.html"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s00535-012-0736-3"}},{"identifier":{"@type":"PMID","@value":"23307044"}}],"dc:title":[{"@value":"Multicolor lineage tracing methods and intestinal tumors"}],"description":[{"notation":[{"@value":"The generation of chimeras, which is now a standard technology for producing gene modified mutant mice, was originally developed as a tool for developmental biology. However, the application of conventional single marker chimeric mice for developmental study was initially limited. This situation has been dramatically changed by development of multicolor chimeric mice using various kinds of fluorescent proteins. Now using our technology, up to ten different clones could be distinguished by their colors, which enable us to perform more accurate statistical analyses and lineage tracing experiments than by conventional methods. This method could be applied to visualize not only cell turnover of normal stem cells but also cancer development of live tissues in vivo. In the present review, we will discuss how these methods have been developed and what questions they are now answering by mainly focusing on intestinal stem cells and intestinal tumors."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699996205514112","@type":"Researcher","foaf:name":[{"@value":"Hirotsugu Yanai"}]},{"@id":"https://cir.nii.ac.jp/crid/1030285133715204224","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70548700"},{"@type":"NRID","@value":"1000070548700"},{"@type":"NRID","@value":"9000018718451"},{"@type":"NRID","@value":"9000021575809"},{"@type":"NRID","@value":"9000017693140"},{"@type":"NRID","@value":"9000345430539"},{"@type":"NRID","@value":"9000021880237"},{"@type":"NRID","@value":"9000308729407"},{"@type":"NRID","@value":"9000406041981"},{"@type":"NRID","@value":"9000350669572"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/tanakato"}],"foaf:name":[{"@value":"Toshihiro Tanaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1030285133348043397","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60332368"},{"@type":"NRID","@value":"1000060332368"},{"@type":"NRID","@value":"9000257935278"},{"@type":"NRID","@value":"9000330324402"},{"@type":"NRID","@value":"9000412454506"},{"@type":"NRID","@value":"9000256626673"},{"@type":"NRID","@value":"9000345430538"},{"@type":"NRID","@value":"9000241863564"},{"@type":"NRID","@value":"9000303923524"},{"@type":"NRID","@value":"9000326658018"},{"@type":"NRID","@value":"9000000189267"},{"@type":"NRID","@value":"9000000429873"},{"@type":"NRID","@value":"9000308729409"},{"@type":"NRID","@value":"9000010318748"},{"@type":"NRID","@value":"9000024427644"},{"@type":"NRID","@value":"9000264272302"},{"@type":"NRID","@value":"9000018837051"},{"@type":"NRID","@value":"9000350669574"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0079199"}],"foaf:name":[{"@value":"Hiroo Ueno"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09441174"},{"@type":"EISSN","@value":"14355922"}],"prism:publicationName":[{"@value":"Journal of Gastroenterology"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2013-01-11","prism:volume":"48","prism:number":"4","prism:startingPage":"423","prism:endingPage":"433"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by-nc/4.0/","https://creativecommons.org/licenses/by-nc/4.0/"],"url":[{"@id":"https://link.springer.com/content/pdf/10.1007/s00535-012-0736-3.pdf"},{"@id":"https://link.springer.com/article/10.1007/s00535-012-0736-3/fulltext.html"},{"@id":"http://link.springer.com/content/pdf/10.1007/s00535-012-0736-3"}],"createdAt":"2013-01-10","modifiedAt":"2021-09-01","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Chimera","dc:title":"Chimera"},{"@id":"https://cir.nii.ac.jp/all?q=Stem%20Cells","dc:title":"Stem Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Gastroenterology","dc:title":"Gastroenterology"},{"@id":"https://cir.nii.ac.jp/all?q=Review","dc:title":"Review"},{"@id":"https://cir.nii.ac.jp/all?q=Luminescent%20Proteins","dc:title":"Luminescent Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Intestinal%20Neoplasms","dc:title":"Intestinal Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Lineage","dc:title":"Cell Lineage"},{"@id":"https://cir.nii.ac.jp/all?q=Intestinal%20Mucosa","dc:title":"Intestinal Mucosa"},{"@id":"https://cir.nii.ac.jp/all?q=Wnt%20Signaling%20Pathway","dc:title":"Wnt Signaling Pathway"},{"@id":"https://cir.nii.ac.jp/all?q=Fluorescent%20Dyes","dc:title":"Fluorescent Dyes"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285710464900736","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Intracellular signals of lung cancer cells as possible therapeutic targets"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710791978112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Identification of normal and neoplastic stem cells by the multicolor lineage tracing methods"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285714469633664","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Lingual Epithelial Stem Cells and Organoid Culture of Them"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166782510208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Intestinal stem cells contribute to the maturation of the neonatal small intestine and colon independently of digestive activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183494063232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Intestinal cancer stem cells marked by Bmi1 or Lgr5 expression contribute to tumor propagation via clonal expansion"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1007/s00535-012-0736-3"},{"@type":"OPENAIRE","@value":"doi_dedup___::8d5cdce5f34efcccaa7a341656dc8fb3"},{"@type":"CROSSREF","@value":"10.1111/cas.12643_references_DOI_N8IucLhQV1NxdzKYSw9iVgX0uU6"},{"@type":"CROSSREF","@value":"10.1111/pin.12425_references_DOI_N8IucLhQV1NxdzKYSw9iVgX0uU6"},{"@type":"CROSSREF","@value":"10.3390/ijms17020168_references_DOI_N8IucLhQV1NxdzKYSw9iVgX0uU6"},{"@type":"CROSSREF","@value":"10.1038/s41598-017-09927-2_references_DOI_N8IucLhQV1NxdzKYSw9iVgX0uU6"},{"@type":"CROSSREF","@value":"10.1038/srep41838_references_DOI_N8IucLhQV1NxdzKYSw9iVgX0uU6"}]}