{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699996209837952.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1155/2016/8590578"}},{"identifier":{"@type":"URI","@value":"http://downloads.hindawi.com/journals/omcl/2016/8590578.pdf"}},{"identifier":{"@type":"URI","@value":"http://downloads.hindawi.com/journals/omcl/2016/8590578.xml"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1155/2016/8590578"}}],"dc:title":[{"@value":"The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Neurodegenerative diseases affect not only the life quality of aging populations, but also their life spans. All forms of neurodegenerative diseases have a massive impact on the elderly. The major threat of these brain diseases includes progressive loss of memory, Alzheimer’s disease (AD), impairments in the movement, Parkinson’s disease (PD), and the inability to walk, talk, and think, Huntington’s disease (HD). Oxidative stress and mitochondrial dysfunction are highlighted as a central feature of brain degenerative diseases. Oxidative stress, a condition that occurs due to imbalance in oxidant and antioxidant status, has been known to play a vital role in the pathophysiology of neurodegenerative diseases including AD, PD, and HD. A large number of studies have utilized oxidative stress biomarkers to investigate the severity of these neurodegenerative diseases and medications are available, but these only treat the symptoms. In traditional medicine, a large number of medicinal plants have been used to treat the symptoms of these neurodegenerative diseases. Extensive studies scientifically validated the beneficial effect of natural products against neurodegenerative diseases using suitable animal models. This short review focuses the role of oxidative stress in the pathogenesis of AD, PD, and HD and the protective efficacy of natural products against these diseases.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699996209837955","@type":"Researcher","foaf:name":[{"@value":"Shanmugam Manoharan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699996209837953","@type":"Researcher","foaf:name":[{"@value":"Gilles J. Guillemin"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699996209837954","@type":"Researcher","foaf:name":[{"@value":"Rajagopal Selladurai Abiramasundari"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699996209837957","@type":"Researcher","foaf:name":[{"@value":"Musthafa Mohamed Essa"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699996209837956","@type":"Researcher","foaf:name":[{"@value":"Mohammed Akbar"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699996209837952","@type":"Researcher","foaf:name":[{"@value":"Mohammed D. Akbar"}]}],"contributor":[{"@id":"https://cir.nii.ac.jp/crid/1380020000290428160","@type":"Researcher","foaf:name":[{"@value":"Rodrigo Franco"}],"role":"editor"}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"19420900"},{"@type":"EISSN","@value":"19420994"}],"prism:publicationName":[{"@value":"Oxidative Medicine and Cellular Longevity"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2016-01","prism:volume":"2016","prism:number":"1","prism:startingPage":"8590578"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"http://downloads.hindawi.com/journals/omcl/2016/8590578.pdf"},{"@id":"http://downloads.hindawi.com/journals/omcl/2016/8590578.xml"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1155/2016/8590578"}],"createdAt":"2016-12-27","modifiedAt":"2024-08-06","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360009142685332096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Differences in pharmacokinetic behaviors of two lipophilic 3‐substituted 2,2,5,5‐tetramethylpyrrolidine‐<i>N</i>‐oxyl radicals, in vivo probes to assess the redox status in the brain using magnetic resonance techniques"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017280653641856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Multifactorial glial responses and their contributions to Alzheimer's disease continuum"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283692290785792","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<i>In vivo</i>ROS production and use of oxidative stress-derived biomarkers to detect the onset of diseases such as Alzheimer’s disease, Parkinson’s disease, and diabetes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302864795251200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Tocotrienols Prevent the Decline of Learning Ability in High-Fat, High-Sucrose Diet-Fed C57BL/6 Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640923467264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"ASK1 in neurodegeneration"}]},{"@id":"https://cir.nii.ac.jp/crid/2050588892098135296","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Molecular tools to detect alloforms of Aβ and Tau : implications for multiplexing and multimodal diagnosis of alzheimer’s disease"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1155/2016/8590578"},{"@type":"CROSSREF","@value":"10.1016/j.jbior.2017.08.003_references_DOI_HEolScPC9PrJdouCZokAWhzC6zI"},{"@type":"CROSSREF","@value":"10.1002/mrm.28499_references_DOI_HEolScPC9PrJdouCZokAWhzC6zI"},{"@type":"CROSSREF","@value":"10.1111/cen3.12745_references_DOI_HEolScPC9PrJdouCZokAWhzC6zI"},{"@type":"CROSSREF","@value":"10.1080/10715762.2017.1315114_references_DOI_HEolScPC9PrJdouCZokAWhzC6zI"},{"@type":"CROSSREF","@value":"10.3390/ijms25063561_references_DOI_HEolScPC9PrJdouCZokAWhzC6zI"},{"@type":"CROSSREF","@value":"10.1246/bcsj.20190356_references_DOI_HEolScPC9PrJdouCZokAWhzC6zI"}]}