{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699996280153600.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/ijc.21866"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.21866"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.21866"}},{"identifier":{"@type":"PMID","@value":"16496379"}}],"dc:title":[{"@value":"<scp>L</scp>‐type amino acid transporter 1 as a potential molecular target in human astrocytic tumors"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p><jats:sc>L</jats:sc>‐type amino acid transporter 1 (LAT1) is a Na<jats:sup>+</jats:sup>‐independent neutral amino acid transport agency and essential for the transport of large neutral amino acids. LAT1 has been identified as a light chain of the CD98 heterodimer from C6 glioma cells. LAT1 also corresponds to TA1, an oncofetal antigen that is expressed primarily in fetal tissues and cancer cells. We have investigated for the first time, the expression of the transporter in the human primary astrocytic tumor tissue from 60 patients. LAT1 is unique because it requires an additional single membrane spanning protein, the heavy chain of 4F2 cell surface antigen (4F2hc), for its functional expression. 4F2hc expression was also determined by immunohistochemistry. Kaplan‐Meier analyses demonstrated that high LAT1 expression correlated with poor survival for the study group as a whole (<jats:italic>p</jats:italic> < 0.0001) and for those with glioblastoma multiforme in particular (<jats:italic>p</jats:italic> = 0.0001). Cox regression analyses demonstrated that LAT1 expression was one of significant predictors of outcome, independent of all other variables. On the basis of these findings, we also investigated the effect of the specific inhibitor to LAT1, 2‐aminobicyclo‐2 (2,2,1)‐heptane‐2‐carboxylic acid (BCH), on the survival of C6 glioma cells <jats:italic>in vitro</jats:italic> and <jats:italic>in vivo</jats:italic> using a rat C6 glioma model. BCH inhibited the growth of C6 glioma cells <jats:italic>in vitro</jats:italic> and <jats:italic>in vivo</jats:italic> in a dose‐dependent manner. Kaplan‐Meier survival data of rats treated with BCH were significant. These findings suggest that LAT1 could be one of the molecular targets in glioma therapy. © 2006 Wiley‐Liss, Inc.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699996280153604","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Nawashiro"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699996280153600","@type":"Researcher","foaf:name":[{"@value":"Naoki Otani"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699996280153472","@type":"Researcher","foaf:name":[{"@value":"Nariyoshi Shinomiya"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699996280153606","@type":"Researcher","foaf:name":[{"@value":"Shinji Fukui"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699996280153473","@type":"Researcher","foaf:name":[{"@value":"Hidetoshi Ooigawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699996280153603","@type":"Researcher","foaf:name":[{"@value":"Katsuji Shima"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699996280153605","@type":"Researcher","foaf:name":[{"@value":"Hirotaka Matsuo"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699996280153602","@type":"Researcher","foaf:name":[{"@value":"Yoshikatsu Kanai"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699996280153601","@type":"Researcher","foaf:name":[{"@value":"Hitoshi Endou"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00207136"},{"@type":"EISSN","@value":"10970215"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00207136"}],"prism:publicationName":[{"@value":"International Journal of Cancer"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2006-05-08","prism:volume":"119","prism:number":"3","prism:startingPage":"484","prism:endingPage":"492"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.21866"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.21866"}],"createdAt":"2006-02-22","modifiedAt":"2023-10-09","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Adolescent","dc:title":"Adolescent"},{"@id":"https://cir.nii.ac.jp/all?q=Fusion%20Regulatory%20Protein%201,%20Heavy%20Chain","dc:title":"Fusion Regulatory Protein 1, Heavy Chain"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Survival","dc:title":"Cell Survival"},{"@id":"https://cir.nii.ac.jp/all?q=Amino%20Acids,%20Cyclic","dc:title":"Amino Acids, Cyclic"},{"@id":"https://cir.nii.ac.jp/all?q=Astrocytoma","dc:title":"Astrocytoma"},{"@id":"https://cir.nii.ac.jp/all?q=Large%20Neutral%20Amino%20Acid-Transporter%201","dc:title":"Large Neutral Amino Acid-Transporter 1"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line,%20Tumor","dc:title":"Cell Line, Tumor"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Wistar","dc:title":"Rats, Wistar"},{"@id":"https://cir.nii.ac.jp/all?q=Child","dc:title":"Child"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Aged,%2080%20and%20over","dc:title":"Aged, 80 and over"},{"@id":"https://cir.nii.ac.jp/all?q=Brain%20Neoplasms","dc:title":"Brain Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Infant,%20Newborn","dc:title":"Infant, Newborn"},{"@id":"https://cir.nii.ac.jp/all?q=Glioma","dc:title":"Glioma"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasms,%20Experimental","dc:title":"Neoplasms, Experimental"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Immunohistochemistry","dc:title":"Immunohistochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Survival%20Analysis","dc:title":"Survival Analysis"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Survival%20Rate","dc:title":"Survival Rate"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002215489938432","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Expression of Amino Acid Transporters (LAT1 and ASCT2) in Patients with Stage III/IV Laryngeal Squamous Cell Carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002216786141184","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Prognostic significance of L-type amino-acid transporter 1 expression in surgically resected pancreatic cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002218146099456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Specific transport of 3‐fluoro‐<scp>l</scp>‐α‐methyl‐tyrosine by <scp>LAT</scp>1 explains its specificity to malignant tumors in imaging"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002218973281408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Relation of LAT1/4F2hc expression with pathological grade, proliferation and angiogenesis in human gliomas"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004230124922624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"CD98 as a novel prognostic indicator for patients with stage III/IV hypopharyngeal squamous cell carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004230195523968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Investigation of the role of transporters on the hepatic elimination of an LAT1 selective inhibitor JPH203"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004230201982336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Clinicopathological significance of LAT1 and ASCT2 in patients with surgically resected esophageal squamous cell carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004231201757568","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Relationship between LAT1 expression and resistance to chemotherapy in pancreatic ductal adenocarcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233396646912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"ASC amino-acid transporter 2 (ASCT2) as a novel prognostic marker in non-small cell lung cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004234886565632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Prognostic significance of L-type amino acid transporter 1 (LAT1) expression in cutaneous melanoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235526484608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Clinicopathological significance of <scp>ASC</scp> amino acid transporter‐2 expression in pancreatic ductal carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004239494815744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"LAT1-Targeting Thermoresponsive Fluorescent Polymer Probes for Cancer Cell Imaging"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004239691246208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"L-type amino acid transporter 1 expression is highly correlated with Gleason score in prostate cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283690311838720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"l-Leucine induces growth arrest and persistent ERK activation in glioma cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283695441125760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Transport of 3-Fluoro-l-α-Methyl-Tyrosine by Tumor-Upregulated L-Type Amino Acid Transporter 1: A Cause of the Tumor Uptake in PET"}]},{"@id":"https://cir.nii.ac.jp/crid/1360286991110860800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Distribution of LAT1-targeting PET tracer was independent of the tumor blood flow in rat xenograft models of C6 glioma and MIA PaCa-2"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643813800576","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Contribution of LAT1-4F2hc in Urological Cancers via Toll-like Receptor and Other Vital Pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298757206643328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Anti-Tumor Effect of the Newly Developed LAT1 Inhibitor JPH203 in Colorectal Carcinoma, According to a Comprehensive Analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165239854592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Diagnostic usefulness of 18F-FAMT PET and L-type amino acid transporter 1 (LAT1) expression in oral squamous cell carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166739717760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Biological significance of fluorine-18-α-methyltyrosine (FAMT) uptake on PET in patients with oesophageal cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168099445760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Boronophenylalanine, a boron delivery agent for boron neutron capture therapy, is transported by <scp>ATB</scp><sup>0,+</sup>, <scp>LAT</scp>1 and <scp>LAT</scp>2"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168099582464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Efficacy of system <scp>l</scp> amino acid transporter 1 inhibition as a therapeutic target in esophageal squamous cell carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567180225551616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Prostate Cancer Cells in Different Androgen Receptor Status Employ Different Leucine Transporters"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181481726848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Clinicopathological Significance of L-type Amino Acid Transporter 1 (LAT1) Expression in Patients with Adenoid Cystic Carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185768580480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"L‐type amino acid transporter‐1 and <scp>CD</scp>98 expression in bone and soft tissue tumors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118739283584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Association of L-type amino acid transporter 1 (LAT1) with the immune system and prognosis in invasive breast cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118740828928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232405176320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Contribution of the L-Type Amino Acid Transporter Family in the Diagnosis and Treatment of Prostate Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641064122368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Expression of L-type amino acid transporter 1 in various skin lesions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643109349248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Correlation of L‐type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656930965760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A new treatment for human malignant melanoma targeting L-type amino acid transporter 1 (LAT1): A pilot study in a canine model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657472182144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"L-type amino acid transporter 1 (LAT1): A new therapeutic target for canine mammary gland tumour"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658748566144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Everolimus and Giant-Cell Astrocytomas in Tuberous Sclerosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848660418138112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Expression of L‐type amino acid transporter 1 (<scp>LAT</scp>1) as a prognostic and therapeutic indicator in multiple myeloma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848661713310592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Clinical significance of L-type amino acid transporter 1 expression as a prognostic marker and potential of new targeting therapy in biliary tract cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567510887424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Correlation of high LAT1 expression with the prognosis of endometrioid carcinoma of the uterine corpus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567836037760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Proteomics and phosphoproteomics reveal key regulators associated with cytostatic effect of amino acid transporter LAT1 inhibitor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861705562972928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Co-expression effect of LLGL2 and SLC7A5 to predict prognosis in ERα-positive breast cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861705598956032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"l-Type amino acid transporter 1 in hypothalamic neurons in mice maintains energy and bone homeostasis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707135861504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Targeting L-type amino acid transporter 1 in urological malignancy: Current status and future perspective"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204640528000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cancer drug delivery targeting amino acid transporters"},{"@language":"ja","@value":"アミノ酸トランスポーターを標的とした癌デリバリー"},{"@language":"ja-Kana","@value":"アミノサン トランスポーター オ ヒョウテキ ト シタ ガン デリバリー"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205180127488","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Establishment and Characterization of Mammalian Cell Lines Stably Expressing Human <sc>L</sc>-Type Amino Acid Transporters"},{"@value":"Establishment and characterization of mammalian cell lines stably expressing human L-type amino acid transporters"},{"@value":"Kim do K, Chairoungdua A, Choi HW, Wempe MF, et al.. Establishment and characterization of mammalian cell lines stably expressing human L-type amino acid transporters."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205546159744","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The role of L-type amino acid transporter 1 in human tumors"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206429034112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Evidence of LAT1 expression in canine caput epididymis"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679600949888","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"L-Type Amino Acid Transporter-1 Expressed in Human Astrocytomas, U343MGa"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680156867200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Establishment of Stable Cell Lines With High Expression of Heterodimers of Human 4F2hc and Human Amino Acid Transporter LAT1 or LAT2 and Delineation of Their Differential Interaction With <I>α</I>-Alkyl Moieties"},{"@value":"Establishment of Stable Cell Lines With High Expression of Heterodimers of Human 4F2hc and Human Amino Acid Transporter LAT1 or LAT2 and Delineation of Their Differential Interaction With α-Alkyl Moieties"},{"@value":"Establishment of Stable Cell Lines With High Expression of Heterodimers of Human 4F2hc and Human Amino Acid Transporter LAT1 or LAT2 and Delineation of Their Differential Interaction With ^|^alpha;-Alkyl Moieties"},{"@value":"Establishment of stable cell lines with high expression of heterodimers of human 4F2hc and human amino acid transporter LAT1 or LAT2 and delineation of their differential interaction with a-alkyl moieties"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681406162816","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Analysis of L-type amino acid transporter in canine hepatocellular carcinoma"},{"@value":"Physiology : Analysis of L-type amino acid transporter in canine hepatocellular carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681406263296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Canine Lat1: Molecular Structure, Distribution and Its Expression in Cancer Samples"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/ijc.21866"},{"@type":"OPENAIRE","@value":"doi_dedup___::61fd85f713bf36f6bd3f45ce6728d485"},{"@type":"CROSSREF","@value":"10.1007/s12253-015-9954-3_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1038/bjc.2012.310_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1111/cas.12878_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1186/1472-6890-12-4_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1002/hed.23797_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1002/jso.24160_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1007/s00280-017-3477-4_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1038/bjc.2014.88_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1097/cmr.0000000000000181_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1111/his.12464_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.3390/ijms19061646_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1292/jvms.11-0353_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1007/s00726-011-1122-9_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1007/s12149-019-01346-9_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1016/j.prp.2014.05.001_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1292/jvms.14-0014_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1292/jvms.14-0392_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.3390/cancers14010229_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.3390/cancers15051383_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1007/s00259-013-2477-9_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1038/bjc.2014.142_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1111/cas.12602_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1111/cas.13021_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1002/pros.23263_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1007/s12253-013-9624-2_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1111/pin.12323_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1254/jphs.12124fp_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.2967/jnumed.112.103069_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.2745/dds.27.342_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1016/j.tvjl.2013.06.016_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1038/s41598-022-06615-8_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1016/j.pharmthera.2021.107964_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.3390/ijms24076178_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1111/j.1349-7006.2011.02151.x_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1111/cas.12529_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1186/1471-2407-13-482_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1007/s00428-020-02781-0_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1111/cas.14756_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1038/s41598-022-20225-4_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1172/jci.insight.154925_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1016/j.jphs.2022.10.002_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2013.08.020_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1056/nejmc1013587_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1254/jphs.08232fp_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.3892/mco.2012.54_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1248/bpb.30.415_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.1002/jps.23601_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"},{"@type":"CROSSREF","@value":"10.5582/irdr.2015.01024_references_DOI_TMx50N0fYOSIX0Xl77ZUlkLzM30"}]}