{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699996307222272.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1152/ajpheart.00209.2001"}},{"identifier":{"@type":"URI","@value":"https://www.physiology.org/doi/pdf/10.1152/ajpheart.00209.2001"}}],"dc:title":[{"@value":"Influence of vascular dimension on gender difference  in flow-dependent dilatation of peripheral conduit arteries"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p> To assess the influence of initial diameter on the gender difference in flow-dependent dilatation (FDD) of the conduit artery, we measured radial artery internal diameter (echotracking), flow (Doppler) and total blood viscosity in 24 healthy (25 ± 0.8 yr) men and women during reactive hyperemia (RH) and during a gradual hand skin heating (SH). At baseline, mean diameter (men, 2.76 ± 0.09 vs. women, 2.32 ± 0.07 mm, P < 0.05), flow (men, 21 ± 4 vs. women, 10 ± 1 ml/min, P < 0.05), and blood viscosity (men, 4.13 ± 0.07 vs. women, 3.92 ± 0.13 cP, P < 0.05) were higher in men but mean shear stress (MSS) was not different between groups. During RH, the percent increase in diameter was lower in men (men, 9 ± 1 vs. women, 13 ± 1%, P< 0.05). This difference was suppressed after correction for baseline diameter. During SH, the increase in diameter with flow was higher in women ( P < 0.01). However, the increase in MSS was higher in women because of their smaller diameter at each level of flow ( P < 0.01) and there was no difference between groups for the increase in diameter at each level of MSS. These results demonstrate in a direct manner that initial diameter influences the magnitude of FDD of conduit arteries in humans by modifying the value of the arterial wall shear stress at each level of flow and support the interest of the heating method in presence of heterogeneous groups. </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699996307222274","@type":"Researcher","foaf:name":[{"@value":"Robinson Joannides"}],"jpcoar:affiliationName":[{"@value":"Department of Pharmacology and"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699996307222273","@type":"Researcher","foaf:name":[{"@value":"Agathe Costentin"}],"jpcoar:affiliationName":[{"@value":"Department of Pharmacology and"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699996307222275","@type":"Researcher","foaf:name":[{"@value":"Michaela Iacob"}],"jpcoar:affiliationName":[{"@value":"Department of Pharmacology and"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699996307222400","@type":"Researcher","foaf:name":[{"@value":"Patricia Compagnon"}],"jpcoar:affiliationName":[{"@value":"Department of Pharmacology and"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699996307222272","@type":"Researcher","foaf:name":[{"@value":"Agnès Lahary"}],"jpcoar:affiliationName":[{"@value":"Department of Hematology, Institut National de la Santé et de la Recherche Médicale E9920, Institut Fédératif de Recherche Multidisciplinaire Sur les Peptides No. 23, Rouen University Hospital, 76031 Rouen, France"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699996307222276","@type":"Researcher","foaf:name":[{"@value":"Christian Thuillez"}],"jpcoar:affiliationName":[{"@value":"Department of Pharmacology and"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03636135"},{"@type":"EISSN","@value":"15221539"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/03636135"}],"prism:publicationName":[{"@value":"American Journal of Physiology-Heart and Circulatory Physiology"}],"dc:publisher":[{"@value":"American Physiological Society"}],"prism:publicationDate":"2002-04-01","prism:volume":"282","prism:number":"4","prism:startingPage":"H1262","prism:endingPage":"H1269"},"reviewed":"false","url":[{"@id":"https://www.physiology.org/doi/pdf/10.1152/ajpheart.00209.2001"}],"createdAt":"2015-03-03","modifiedAt":"2019-09-08","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050287142183370496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Unique hemoglobin dynamics in female Tibetan highlanders"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285709398563328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A novel photoplethysmography technique to derive normalized arterial stiffness as a blood pressure independent measure in the finger vascular bed"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679409000704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Use of Ultrasound for Non-Invasive Assessment of Flow-Mediated Dilation"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1152/ajpheart.00209.2001"},{"@type":"CROSSREF","@value":"10.5551/jat.11395_references_DOI_YKjshFMSmWSzDbtQ60tGiDJqszC"},{"@type":"CROSSREF","@value":"10.1186/s41182-020-00289-6_references_DOI_YKjshFMSmWSzDbtQ60tGiDJqszC"},{"@type":"CROSSREF","@value":"10.1088/0967-3334/32/11/003_references_DOI_YKjshFMSmWSzDbtQ60tGiDJqszC"}]}