Role of trehalose phosphate synthase and trehalose during hypoxia: from flies to mammals

DOI PDF 被引用文献9件
  • Qiaofang Chen
    Department of Pediatrics and Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA
  • Gabriel G. Haddad
    Department of Pediatrics and Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA

書誌事項

公開日
2004-08-15
DOI
  • 10.1242/jeb.01133
公開者
The Company of Biologists

この論文をさがす

説明

<jats:title>SUMMARY</jats:title> <jats:p>Trehalose is a nonreducing disaccharide in which the two glucose units are linked in an α,α-1,1-glycosidic linkage. The best known and most widely distributed pathway of trehalose synthesis involves the transfer of glucose from UDP-glucose to glucose 6-phosphate to form trehalose-6-phosphate and UDP via the trehalose-6-phosphate synthase (TPS1). Trehalose-6-phosphate phosphatase (TPS2) then converts trehalose-6-phosphate to free trehalose. This sugar is present in a wide variety of organisms,including bacteria, yeast, fungi, insects, invertebrates and plants, and because of its particular physical features, trehalose is able to protect the integrity of cells against a variety of environmental stresses such as desiccation, dehydration, heat, cold and oxidation. Our current studies described here indicate that trehalose protects Drosophila and mammalian cells from hypoxic and anoxic injury. The mechanism of this protection is probably related to a decrease in protein denaturation through protein–trehalose interactions.</jats:p>

収録刊行物

被引用文献 (9)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ