{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699996356372608.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1242/jeb.01133"}},{"identifier":{"@type":"URI","@value":"http://journals.biologists.com/jeb/article-pdf/207/18/3125/1247855/3125.pdf"}},{"identifier":{"@type":"NAID","@value":"30002330574"}}],"dc:title":[{"@value":"Role of trehalose phosphate synthase and trehalose during hypoxia: from flies to mammals"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>SUMMARY</jats:title>\n               <jats:p>Trehalose is a nonreducing disaccharide in which the two glucose units are linked in an α,α-1,1-glycosidic linkage. The best known and most widely distributed pathway of trehalose synthesis involves the transfer of glucose from UDP-glucose to glucose 6-phosphate to form trehalose-6-phosphate and UDP via the trehalose-6-phosphate synthase (TPS1). Trehalose-6-phosphate phosphatase (TPS2) then converts trehalose-6-phosphate to free trehalose. This sugar is present in a wide variety of organisms,including bacteria, yeast, fungi, insects, invertebrates and plants, and because of its particular physical features, trehalose is able to protect the integrity of cells against a variety of environmental stresses such as desiccation, dehydration, heat, cold and oxidation. Our current studies described here indicate that trehalose protects Drosophila and mammalian cells from hypoxic and anoxic injury. The mechanism of this protection is probably related to a decrease in protein denaturation through protein–trehalose interactions.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381699996356372608","@type":"Researcher","foaf:name":[{"@value":"Qiaofang Chen"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatrics and Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699996356372609","@type":"Researcher","foaf:name":[{"@value":"Gabriel G. Haddad"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatrics and Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"14779145"},{"@type":"PISSN","@value":"00220949"}],"prism:publicationName":[{"@value":"Journal of Experimental Biology"}],"dc:publisher":[{"@value":"The Company of Biologists"}],"prism:publicationDate":"2004-08-15","prism:volume":"207","prism:number":"18","prism:startingPage":"3125","prism:endingPage":"3129"},"reviewed":"false","url":[{"@id":"http://journals.biologists.com/jeb/article-pdf/207/18/3125/1247855/3125.pdf"}],"createdAt":"2004-08-06","modifiedAt":"2021-04-25","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285712525660544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Metabolome Analysis of Drosophila melanogaster during Embryogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617622970368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Trehalose alleviates oxidative stress-mediated liver injury and Mallory-Denk body formation via activating autophagy in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168116480768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Trehalose activates autophagy and decreases proteasome inhibitor‐induced endoplasmic reticulum stress and oxidative stress‐mediated cytotoxicity in hepatocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168251756160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Enzymatic control of anhydrobiosis‐related accumulation of trehalose in the sleeping chironomid, <i>Polypedilum vanderplanki</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848662519155328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206430368000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Trehalose May Prevent Postsurgical Adhesions in a Rabbit Model of Hysterotomy"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681404832768","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of Trehalose Coating on Basic Fibroblast Growth Factor Release from Tailor-Made Bone Implants"},{"@value":"Surgery : Effect of Trehalose Coating on Basic Fibroblast Growth Factor Release from Tailor-Made Bone Implants"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681406919552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Lyophilized Aspirin with Trehalose May Decrease the Incidence of Gastric Injuries in Healthy Dogs"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417125467487616","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Discovery of the Genes in Response to White Spot Syndrome Virus (WSSV) Infection in Fenneropenaeus chinensis Through cDNA Microarray"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1242/jeb.01133"},{"@type":"CIA","@value":"30002330574"},{"@type":"CROSSREF","@value":"10.1292/jvms.10-0342_references_DOI_730pkMbTIH20v2t8UUImIr5lwXa"},{"@type":"CROSSREF","@value":"10.1292/jvms.12-0109_references_DOI_730pkMbTIH20v2t8UUImIr5lwXa"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0099519_references_DOI_730pkMbTIH20v2t8UUImIr5lwXa"},{"@type":"CROSSREF","@value":"10.1007/s00795-020-00258-2_references_DOI_730pkMbTIH20v2t8UUImIr5lwXa"},{"@type":"CROSSREF","@value":"10.1111/hepr.12892_references_DOI_730pkMbTIH20v2t8UUImIr5lwXa"},{"@type":"CROSSREF","@value":"10.1111/j.1742-4658.2010.07811.x_references_DOI_730pkMbTIH20v2t8UUImIr5lwXa"},{"@type":"CROSSREF","@value":"10.1292/jvms.11-0016_references_DOI_730pkMbTIH20v2t8UUImIr5lwXa"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0152628_references_DOI_730pkMbTIH20v2t8UUImIr5lwXa"}]}