{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361699996402528000.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1177/096805199400100304"}},{"identifier":{"@type":"URI","@value":"https://journals.sagepub.com/doi/pdf/10.1177/096805199400100304"}},{"identifier":{"@type":"NAID","@value":"30033943574"}}],"dc:title":[{"@value":"Synthesis and purification by HPLC of des-O-acyl partial structures of Escherichia coli Re lipopolysaccharide"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p> Four compounds corresponding to partial structures of Re-type lipopolysaccharide (LPS) were synthesized for precise investigation of immunological properties of the 3-deoxy-D- manno-2-octulosonic acid (Kdo)-containing inner core and lipid A regions of LPS. The synthetic compounds lack all the ester-bound acyl groups which are present in natural LPS but known to be not essential for the antigenicity. The simplest compound is N,N'-diacylated glucosamine β1-6 disaccharide 4'-monophosphate 2 which corresponds to the des- O-acyl derivative of 1-dephospho lipid A. The other three contain one or two Kdo moieties linked to 2. The most complex one is a tetrasaccharide equivalent to the des- O-acylated 1-dephosphorylated derivative of LPS from Escherichia coli Re-mutant. Syntheses were performed by stepwise condensation of appropriately protected sugar moieties and final hydrogenolytic deprotection. The synthetic des- O-acyl LPS analogs were effectively purified by means of reversed phase HPLC to give homogeneous preparations. </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1583105976230068992","@type":"Researcher","foaf:name":[{"@value":"K. Fukase"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry, Faculty of Science, Osaka University, Osaka, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699996402528000","@type":"Researcher","foaf:name":[{"@value":"M. Kurosawa"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry, Faculty of Science, Osaka University, Osaka, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1381699996402528002","@type":"Researcher","foaf:name":[{"@value":"S. Kusumoto"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry, Faculty of Science, Osaka University, Osaka, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09680519"}],"prism:publicationName":[{"@value":"Journal of Endotoxin Research"}],"dc:publisher":[{"@value":"SAGE Publications"}],"prism:publicationDate":"1994-09","prism:volume":"1","prism:number":"3","prism:startingPage":"149","prism:endingPage":"163"},"reviewed":"false","dc:rights":["https://journals.sagepub.com/page/policies/text-and-data-mining-license"],"url":[{"@id":"https://journals.sagepub.com/doi/pdf/10.1177/096805199400100304"}],"createdAt":"2008-01-25","modifiedAt":"2025-02-28","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390282679123999872","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Key structures of bacterial peptidoglycan and lipopolysaccharide triggering the innate immune system of higher animals: Chemical synthesis and functional studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679348205952","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Chemical Synthesis of Re-type Lipopolysaccharide."},{"@value":"Ｒｅ型リポ多糖の全合成"},{"@language":"ja-Kana","@value":"Reガタ リポ タトウ ノ ゼンゴウセイ ガン エイブン"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680316829056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Synthesis of Bacterial Glycoconjugates and Their Bio-functional Studies in Innate Immunity"},{"@language":"ja","@value":"細菌由来複合糖質の合成と自然免疫研究"},{"@language":"ja-Kana","@value":"サイキン ユライ フクゴウ トウシツ ノ ゴウセイ ト シゼン メンエキ ケンキュウ"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1177/096805199400100304"},{"@type":"CIA","@value":"30033943574"},{"@type":"OPENAIRE","@value":"doi_dedup___::077bad9a3b0d6049dfc37594c9a70b20"},{"@type":"CROSSREF","@value":"10.5059/yukigoseikyokaishi.70.113_references_DOI_KuscH4yCckNVOHKcwkQkPt8cBOJ"},{"@type":"CROSSREF","@value":"10.2183/pjab.86.322_references_DOI_KuscH4yCckNVOHKcwkQkPt8cBOJ"}]}