Structure and hemolytic activity relationships of triterpenoid saponins and sapogenins
書誌事項
- 公開日
- 2016-08-04
- 資源種別
- journal article
- 権利情報
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- http://www.springer.com/tdm
- DOI
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- 10.1007/s11418-016-1026-9
- 公開者
- Springer Science and Business Media LLC
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説明
We evaluated the hemolytic activity of 41 commercially available triterpenoid saponins and sapogenins derived from three types of structural skeletons. Structure-activity relationships were established by comparing the structural characteristics of both the aglycone and sugar moieties among the tested compounds. The majority of oleanane-type sapogenins had stronger hemolytic effects than those of the ursane and dammarane types. The presence of polar regions on sapogenins, such as a carboxyl (COOH) at position 28, an α-hydroxyl (α-OH) at position 16, and/or a β-hydroxyl (β-OH) at position 2, significantly enhanced hemolysis. Meanwhile, the introduction of an α-OH at position 2 or a methyl hydroxyl (CH
収録刊行物
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- Journal of Natural Medicines
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Journal of Natural Medicines 71 (1), 50-58, 2016-08-04
Springer Science and Business Media LLC
