{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361975840910752256.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1007/s11418-016-1026-9"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/article/10.1007/s11418-016-1026-9/fulltext.html"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s11418-016-1026-9.pdf"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s11418-016-1026-9"}},{"identifier":{"@type":"PMID","@value":"27491744"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Structure and hemolytic activity relationships of triterpenoid saponins and sapogenins"}],"description":[{"notation":[{"@value":"We evaluated the hemolytic activity of 41 commercially available triterpenoid saponins and sapogenins derived from three types of structural skeletons. Structure-activity relationships were established by comparing the structural characteristics of both the aglycone and sugar moieties among the tested compounds. The majority of oleanane-type sapogenins had stronger hemolytic effects than those of the ursane and dammarane types. The presence of polar regions on sapogenins, such as a carboxyl (COOH) at position 28, an α-hydroxyl (α-OH) at position 16, and/or a β-hydroxyl (β-OH) at position 2, significantly enhanced hemolysis. Meanwhile, the introduction of an α-OH at position 2 or a methyl hydroxyl (CH"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381975840910752260","@type":"Researcher","foaf:name":[{"@value":"Nhu Ngoc Quynh Vo"}]},{"@id":"https://cir.nii.ac.jp/crid/1381975840910752259","@type":"Researcher","foaf:name":[{"@value":"Ery Odette Fukushima"}]},{"@id":"https://cir.nii.ac.jp/crid/1381975840910752261","@type":"Researcher","foaf:name":[{"@value":"Toshiya Muranaka"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13403443"},{"@type":"EISSN","@value":"18610293"}],"prism:publicationName":[{"@value":"Journal of Natural Medicines"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2016-08-04","prism:volume":"71","prism:number":"1","prism:startingPage":"50","prism:endingPage":"58"},"reviewed":"false","dc:rights":["http://www.springer.com/tdm"],"url":[{"@id":"http://link.springer.com/article/10.1007/s11418-016-1026-9/fulltext.html"},{"@id":"http://link.springer.com/content/pdf/10.1007/s11418-016-1026-9.pdf"},{"@id":"http://link.springer.com/content/pdf/10.1007/s11418-016-1026-9"}],"createdAt":"2016-08-04","modifiedAt":"2018-04-03","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Structure-Activity%20Relationship","dc:title":"Structure-Activity Relationship"},{"@id":"https://cir.nii.ac.jp/all?q=Sapogenins","dc:title":"Sapogenins"},{"@id":"https://cir.nii.ac.jp/all?q=Saponins","dc:title":"Saponins"},{"@id":"https://cir.nii.ac.jp/all?q=Hemolysis","dc:title":"Hemolysis"},{"@id":"https://cir.nii.ac.jp/all?q=Triterpenes","dc:title":"Triterpenes"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781831020160","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15H04485"},{"@type":"JGN","@value":"JP15H04485"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04485/"}],"notation":[{"@language":"ja","@value":"ゲノム編集技術を駆使した植物トリテルペノイド生合成遺伝子の機能解析"},{"@language":"en","@value":"Functional analysis of triterpenoid biosynthetic genes in plant by using genome editing"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144743492224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hemolysis caused by polyoxyethylene-derived surfactants evidence for peroxide 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