{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361975841658827264.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.ekir.2019.08.015"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2468024919314718?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2468024919314718?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"31845924"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Autoantibodies Specific for Galactose-Deficient IgA1 in IgA Vasculitis With Nephritis"}],"description":[{"notation":[{"@value":"Patients with IgA nephropathy (IgAN) have elevated serum levels of galactose-deficient IgA1 (Gd-IgA1) that are bound by Gd-IgA1-specific autoantibodies in pathogenic immune complexes. Renal biopsy histopathologic features of IgA vasculitis (IgAV) with nephritis (IgAV-N) are similar to those of IgAN. Mucosal infections often are associated with clinical onset and exacerbation in both diseases. We investigated whether patients with IgAV-N share pathogenic characteristics of IgAN.We generated IgA1- and IgG-secreting cell lines from Epstein-Barr virus (EBV)-immortalized cells of patients with IgAV without nephritis (IgAV-woN), IgAV-N, and IgAN and from healthy individuals. Sera and cell-culture supernatants were used for analysis of Gd-IgA1 and Gd-IgA1-specific IgG autoantibodies.IgA1-producing cells from patients with IgAV-N, like cells from patients with IgAN, secreted more Gd-IgA1 than did cells from patients with IgAV-woN or healthy control subjects, in agreement with elevated serum Gd-IgA1 levels in patients with IgAV-N and IgAN. IgA1-producing cells from patients with IgAV-N had altered expression of genes involved inSerum levels and cellular production of Gd-IgA1 and Gd-IgA1-specific IgG autoantibodies were elevated in patients with IgAV-N, supporting the hypothesis that IgAV-N and IgAN share pathogenic features."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751158647808","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10468572"},{"@type":"NRID","@value":"1000010468572"},{"@type":"NRID","@value":"9000005990282"},{"@type":"NRID","@value":"9000398624487"},{"@type":"NRID","@value":"9000370283083"},{"@type":"NRID","@value":"9000020983780"},{"@type":"NRID","@value":"9000002367319"},{"@type":"NRID","@value":"9000023596270"},{"@type":"NRID","@value":"9000248224132"},{"@type":"NRID","@value":"9000415088579"},{"@type":"NRID","@value":"9000402763942"},{"@type":"NRID","@value":"9000022375742"},{"@type":"NRID","@value":"9000238932093"},{"@type":"NRID","@value":"9000309181770"},{"@type":"NRID","@value":"9000002854815"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/hyy"}],"foaf:name":[{"@value":"Hitoshi Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1381975841658827267","@type":"Researcher","foaf:name":[{"@value":"Zina Moldoveanu"}]},{"@id":"https://cir.nii.ac.jp/crid/1381975841658827268","@type":"Researcher","foaf:name":[{"@value":"Bruce A. Julian"}]},{"@id":"https://cir.nii.ac.jp/crid/1381975841658827266","@type":"Researcher","foaf:name":[{"@value":"Robert J. Wyatt"}]},{"@id":"https://cir.nii.ac.jp/crid/1381975841658827265","@type":"Researcher","foaf:name":[{"@value":"Jan Novak"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"24680249"}],"prism:publicationName":[{"@value":"Kidney International Reports"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2019-12","prism:volume":"4","prism:number":"12","prism:startingPage":"1717","prism:endingPage":"1724"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","http://creativecommons.org/licenses/by-nc-nd/4.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S2468024919314718?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S2468024919314718?httpAccept=text/plain"}],"createdAt":"2019-08-30","modifiedAt":"2019-12-03","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Clinical%20Research","dc:title":"Clinical Research"},{"@id":"https://cir.nii.ac.jp/all?q=RC870-923","dc:title":"RC870-923"},{"@id":"https://cir.nii.ac.jp/all?q=Diseases%20of%20the%20genitourinary%20system.%20Urology","dc:title":"Diseases of the genitourinary system. Urology"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782000598272","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18K08252"},{"@type":"JGN","@value":"JP18K08252"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K08252/"}],"notation":[{"@language":"ja","@value":"IgA腎症における糖鎖異常IgA産生形質細胞の分化とホーミングメカニズムの解明"},{"@language":"en","@value":"Mechanisms of differentiation and homing of aberrantly glycosylated IgA producing cells in the pathogenesis of IgA nephropathy"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050294045368759936","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Glomerular galactose-deficient IgA1 expression analysis in pediatric patients with glomerular diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360022305559882496","@type":"Article","resourceType":"学術雑誌論文(journal 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