{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361978698488889984.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1007/s11604-012-0133-0"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s11604-012-0133-0.pdf"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/article/10.1007/s11604-012-0133-0/fulltext.html"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s11604-012-0133-0"}},{"identifier":{"@type":"PMID","@value":"23001374"}},{"identifier":{"@type":"NAID","@value":"50008492398"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2013186411"}}],"dc:title":[{"@value":"Negatively charged superparamagnetic iron oxide nanoparticles: a new blood-pooling magnetic resonance contrast agent"}],"description":[{"notation":[{"@value":"Our purpose was to investigate the utility of superparamagnetic iron-oxide nanoparticles (SPIO) as a blood-pooling contrast agent at magnetic resonance imaging (MRI).We studied four contrast agents: carboxymethyl-diethylaminoethyl dextran magnetite SPIO (CMEADM-S, diameter 54 nm), negatively charged CMEADM ultrasmall SPIO (CMEADM-U, 32 nm), alkali-treated dextran magnetite SPIO (ATDM-S, 55 nm), and ATDM ultrasmall SPIO (ATDM-U, 28 nm) carrying a neutral charge. Each contrast agent (80 μmol/kg) was injected intraperitoneally into apolipoprotein E (apoE) mice and the tissue iron concentration was measured 30-, 60-, 180-, and 300-min later by nuclear MR. For MR angiographic (MRA) evaluation, we injected the agents into the auricular vein of four groups of 15 rabbits. Immediately and 30-, 60-, 180-, and 300-min later, three rabbits from each group were subjected to MRI. The organ/background signal ratio (SR) was calculated. Statistical analyses were performed with Tukey's honestly significant difference (HSD) test.At 60 and 180 min, blood-iron concentration of CMEADM-U was significantly different from other contrast agents. In the abdominal aorta and inferior vena cava, SR of CMEADM-U was higher at 180 and 300 min than of the other contrast agents. In the thoracic aorta, there was no difference in SR at 300 min between CMEADM-U and CMEADM-S.Negatively charged SPIO nanoparticles may be useful as a blood-pooling contrast agent."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1582543180515242242","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000415230974"}],"foaf:name":[{"@value":"Norihisa Nitta"}]},{"@id":"https://cir.nii.ac.jp/crid/1582543180515242369","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000415230975"}],"foaf:name":[{"@value":"Keiko 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Sonoda"}]},{"@id":"https://cir.nii.ac.jp/crid/1582543180515242240","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000415230977"}],"foaf:name":[{"@value":"Shinichi Ota"}]},{"@id":"https://cir.nii.ac.jp/crid/1582543180515242243","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000415230978"}],"foaf:name":[{"@value":"Noritoshi Ushio"}]},{"@id":"https://cir.nii.ac.jp/crid/1582543180515242241","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000415230979"}],"foaf:name":[{"@value":"Masashi Takahashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1582543180515242245","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000415230980"}],"foaf:name":[{"@value":"Kiyoshi Murata"}]},{"@id":"https://cir.nii.ac.jp/crid/1582543180515242244","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000415230981"}],"foaf:name":[{"@value":"Satoshi Nohara"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"18671071"},{"@type":"EISSN","@value":"1867108X"}],"prism:publicationName":[{"@value":"Japanese Journal of Radiology"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2012-09-22","prism:volume":"30","prism:number":"10","prism:startingPage":"832","prism:endingPage":"839"},"reviewed":"false","dc:rights":["http://www.springer.com/tdm"],"url":[{"@id":"http://link.springer.com/content/pdf/10.1007/s11604-012-0133-0.pdf"},{"@id":"http://link.springer.com/article/10.1007/s11604-012-0133-0/fulltext.html"},{"@id":"http://link.springer.com/content/pdf/10.1007/s11604-012-0133-0"},{"@id":"https://search.jamas.or.jp/link/ui/2013186411"}],"createdAt":"2012-09-21","modifiedAt":"2022-01-29","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Contrast%20Media","dc:title":"Contrast Media"},{"@id":"https://cir.nii.ac.jp/all?q=Ferric%20Compounds","dc:title":"Ferric 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