{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361981468456650752.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1161/strokeaha.113.002470"}},{"identifier":{"@type":"URI","@value":"https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.113.002470"}}],"dc:title":[{"@value":"N2 Neutrophils, Novel Players in Brain Inflammation After Stroke"}],"dcterms:alternative":[{"@value":"Modulation by the PPARγ Agonist Rosiglitazone"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec>\n            <jats:title>Background and Purpose—</jats:title>\n            <jats:p>Neutrophils have been traditionally recognized as major mediators of a deleterious inflammatory response in acute ischemic stroke, but their potential as a therapeutic target remains unexplored. Recent evidence indicates that neutrophils may acquire different phenotypes and contribute to resolution of inflammation through the release of anti-inflammatory mediators. Thus, similar to M2 macrophages, neutrophils have been proposed to shift toward an N2 phenotype, a polarization that is peroxisome proliferator-activated receptor-γ dependent in macrophages. We hypothesize that peroxisome proliferator-activated receptor-γ activation with rosiglitazone induces changes in neutrophilic mobilization and phenotype that might influence stroke outcome.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Methods—</jats:title>\n            <jats:p>Brain sections and cell suspensions were prepared from mice exposed to permanent distal middle cerebral artery occlusion. Double immunostaining with stereological counting of brain sections and flow-cytometry analysis of brain cell suspensions were performed.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Results—</jats:title>\n            <jats:p>Rosiglitazone accelerated neutrophil infiltration to the ischemic core, concomitantly to neuroprotection. Some neutrophils (≈31%) expressed M2 markers, namely Ym1 and CD206 (mannose receptor). After treatment with the peroxisome proliferator-activated receptor-γ agonist rosiglitazone, most neutrophils (≈77%) acquired an N2 phenotype. Interestingly, rosiglitazone increased neutrophil engulfment by microglia/macrophages, a clearance that preferentially affected the N2 subset.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions—</jats:title>\n            <jats:p>We present the first evidence of neutrophil reprogramming toward an N2 phenotype in brain inflammation, which can be modulated by activation of the peroxisome proliferator-activated receptor-γ nuclear receptor. We also show that N2 polarization is associated with an increased neutrophil clearance, thus suggesting that this switch is a crucial event for resolution of inflammation that may participate in neuroprotection.</jats:p>\n          </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381981468456650624","@type":"Researcher","foaf:name":[{"@value":"María Isabel Cuartero"}],"jpcoar:affiliationName":[{"@value":"From the Unidad de Investigación Neurovascular, Departamento de Farmacología, Facultad de Medicina, Universidad Complutense, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC) and Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Madrid, Spain (M.I.C., I.B., A.M., I.L., M.A.M.); Servicio de Neurología and Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Madrid, Spain (F.N., J.V.); Arthritis and Inflammation Research Centre,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981468456650756","@type":"Researcher","foaf:name":[{"@value":"Iván Ballesteros"}],"jpcoar:affiliationName":[{"@value":"From the Unidad de Investigación Neurovascular, Departamento de Farmacología, Facultad de Medicina, Universidad Complutense, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC) and Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Madrid, Spain (M.I.C., I.B., A.M., I.L., M.A.M.); Servicio de Neurología and Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Madrid, Spain (F.N., J.V.); Arthritis and Inflammation Research Centre,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981468456650758","@type":"Researcher","foaf:name":[{"@value":"Ana Moraga"}],"jpcoar:affiliationName":[{"@value":"From the Unidad de Investigación Neurovascular, Departamento de Farmacología, Facultad de Medicina, Universidad Complutense, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC) and Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Madrid, Spain (M.I.C., I.B., A.M., I.L., M.A.M.); Servicio de Neurología and Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Madrid, Spain (F.N., J.V.); Arthritis and Inflammation Research Centre,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981468456650752","@type":"Researcher","foaf:name":[{"@value":"Florentino Nombela"}],"jpcoar:affiliationName":[{"@value":"From the Unidad de Investigación Neurovascular, Departamento de Farmacología, Facultad de Medicina, Universidad Complutense, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC) and Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Madrid, Spain (M.I.C., I.B., A.M., I.L., M.A.M.); Servicio de Neurología and Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Madrid, Spain (F.N., J.V.); Arthritis and Inflammation Research Centre,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981468456650753","@type":"Researcher","foaf:name":[{"@value":"José Vivancos"}],"jpcoar:affiliationName":[{"@value":"From the Unidad de Investigación Neurovascular, Departamento de Farmacología, Facultad de Medicina, Universidad Complutense, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC) and Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Madrid, Spain (M.I.C., I.B., A.M., I.L., M.A.M.); Servicio de Neurología and Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Madrid, Spain (F.N., J.V.); Arthritis and Inflammation Research Centre,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981468456650759","@type":"Researcher","foaf:name":[{"@value":"John A. Hamilton"}],"jpcoar:affiliationName":[{"@value":"From the Unidad de Investigación Neurovascular, Departamento de Farmacología, Facultad de Medicina, Universidad Complutense, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC) and Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Madrid, Spain (M.I.C., I.B., A.M., I.L., M.A.M.); Servicio de Neurología and Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Madrid, Spain (F.N., J.V.); Arthritis and Inflammation Research Centre,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981468456650757","@type":"Researcher","foaf:name":[{"@value":"Ángel L. Corbí"}],"jpcoar:affiliationName":[{"@value":"From the Unidad de Investigación Neurovascular, Departamento de Farmacología, Facultad de Medicina, Universidad Complutense, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC) and Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Madrid, Spain (M.I.C., I.B., A.M., I.L., M.A.M.); Servicio de Neurología and Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Madrid, Spain (F.N., J.V.); Arthritis and Inflammation Research Centre,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981468456650755","@type":"Researcher","foaf:name":[{"@value":"Ignacio Lizasoain"}],"jpcoar:affiliationName":[{"@value":"From the Unidad de Investigación Neurovascular, Departamento de Farmacología, Facultad de Medicina, Universidad Complutense, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC) and Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Madrid, Spain (M.I.C., I.B., A.M., I.L., M.A.M.); Servicio de Neurología and Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Madrid, Spain (F.N., J.V.); Arthritis and Inflammation Research Centre,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981468456650754","@type":"Researcher","foaf:name":[{"@value":"María A. Moro"}],"jpcoar:affiliationName":[{"@value":"From the Unidad de Investigación Neurovascular, Departamento de Farmacología, Facultad de Medicina, Universidad Complutense, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC) and Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Madrid, Spain (M.I.C., I.B., A.M., I.L., M.A.M.); Servicio de Neurología and Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Madrid, Spain (F.N., J.V.); Arthritis and Inflammation Research Centre,..."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00392499"},{"@type":"EISSN","@value":"15244628"}],"prism:publicationName":[{"@value":"Stroke"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2013-12","prism:volume":"44","prism:number":"12","prism:startingPage":"3498","prism:endingPage":"3508"},"reviewed":"false","url":[{"@id":"https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.113.002470"}],"createdAt":"2013-10-18","modifiedAt":"2024-05-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002216115750912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Activation of RXR/PPARγ underlies neuroprotection by bexarotene in ischemic stroke"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004231202439680","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pivotal role of innate myeloid cells in cerebral post-ischemic sterile inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017282461622912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neuroimmune mechanisms and therapies mediating post-ischaemic brain injury and repair"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285714424844160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Post-ischemic inflammation regulates neural damage and protection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185742034944","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Keratin pearl degradation in oral squamous cell carcinoma: reciprocal roles of neutrophils and macrophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232185350016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Enhanced angiogenic properties of umbilical cord blood primed by OP9 stromal cells ameliorates neurological deficits in cerebral infarction mouse model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643369155584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neutrophils scan for activated platelets to initiate inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361694366921840256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Interactions between rat cortico-striatal slice cultures and neutrophil-like HL60 cells under thrombin challenge: Toward elucidation of pathological events in intracerebral hemorrhage"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1161/strokeaha.113.002470"},{"@type":"CROSSREF","@value":"10.1007/s00281-018-0707-8_references_DOI_136Ri3pt6hGieOa3NTOjRbFh6s"},{"@type":"CROSSREF","@value":"10.1038/s41583-023-00690-0_references_DOI_136Ri3pt6hGieOa3NTOjRbFh6s"},{"@type":"CROSSREF","@value":"10.3389/fncel.2014.00319_references_DOI_136Ri3pt6hGieOa3NTOjRbFh6s"},{"@type":"CROSSREF","@value":"10.1016/j.jphs.2019.12.006_references_DOI_136Ri3pt6hGieOa3NTOjRbFh6s"},{"@type":"CROSSREF","@value":"10.1111/jop.12197_references_DOI_136Ri3pt6hGieOa3NTOjRbFh6s"},{"@type":"CROSSREF","@value":"10.1016/j.phrs.2015.10.009_references_DOI_136Ri3pt6hGieOa3NTOjRbFh6s"},{"@type":"CROSSREF","@value":"10.1038/s41598-023-27424-7_references_DOI_136Ri3pt6hGieOa3NTOjRbFh6s"},{"@type":"CROSSREF","@value":"10.1126/science.1256478_references_DOI_136Ri3pt6hGieOa3NTOjRbFh6s"}]}