Persistence of Memory CD8 T Cells in MHC Class I-Deficient Mice

DOI Web Site 被引用文献7件
  • Kaja Murali-Krishna
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA.
  • Lisa L. Lau
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA.
  • Suryaprakash Sambhara
    Pasteur Merieux Connaught Canada, North York, Ontario M2R 3TA, Canada.
  • Francois Lemonnier
    Departement du SIDA et des Retrovirus, Institut Pasteur, Paris 75724, France.
  • John Altman
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA.
  • Rafi Ahmed
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA.

説明

<jats:p>An understanding of how T cell memory is maintained is crucial for the rational design of vaccines. Memory T cells were shown to persist indefinitely in major histocompatibility complex (MHC) class I–deficient mice and retained the ability to make rapid cytokine responses upon reencounter with antigen. In addition, memory CD8 T cells, unlike naı̈ve cells, divided without MHC–T cell receptor interactions. This “homeostatic” proliferation is likely to be important in maintaining memory T cell numbers in the periphery. Thus, after naı̈ve CD8 T cells differentiate into memory cells, they evolve an MHC class I–independent “life-style” and do not require further stimulation with specific or cross-reactive antigen for their maintenance.</jats:p>

収録刊行物

  • Science

    Science 286 (5443), 1377-1381, 1999-11-12

    American Association for the Advancement of Science (AAAS)

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