{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361981469002138496.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/j.1750-3639.2008.00138.x"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1750-3639.2008.00138.x"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1750-3639.2008.00138.x"}}],"dc:title":[{"@value":"Amoeboid Microglia in the Periventricular White Matter Induce Oligodendrocyte Damage through Expression of Proinflammatory Cytokines via MAP Kinase Signaling Pathway in Hypoxic Neonatal Rats"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Hypoxic injury in the perinatal period results in periventricular white matter (PWM) lesions with axonal damage and oligodendroglial loss. It also alters macrophage function by perpetuating expression of inflammatory mediators. Relevant to this is the preponderance of amoeboid microglial cells (AMC) characterized as active macrophages in the developing PWM. This study aimed to determine if AMC produce proinflammatory cytokines that may be linked to the oligodendroglial loss observed in hypoxic PWM damage (PWMD). Wistar rats (1 day old) were subjected to hypoxia, following which upregulated expression of tumor necrosis factor‐α (TNF‐α), interleukin‐1β (IL‐1β), TNF receptor 1 (TNF‐R<jats:sub>1</jats:sub>) and IL‐1 receptor 1 (IL‐1R<jats:sub>1</jats:sub>) was observed. This was coupled with apoptosis and expression of TNF‐R<jats:sub>1</jats:sub> and IL‐1R<jats:sub>1</jats:sub> in oligodendrocytes. Primary cultured microglial cells subjected to hypoxia (3% oxygen, 5% CO<jats:sub>2</jats:sub> and 92% nitrogen) showed enhanced expression of TNF‐α and IL‐1β. Furthermore, mitogen‐activated protein (MAP) kinase signaling pathway was involved in the expression of TNF‐α and IL‐1β in microglia subjected to hypoxia. Our results suggest that following a hypoxic insult, microglial cells in the neonatal rats produce inflammatory cytokines such as TNF‐α and IL‐1β via MAP kinase signaling pathway. These cytokines are detrimental to oligodendrocytes resulting in PWM lesion.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381981469002138500","@type":"Researcher","foaf:name":[{"@value":"YiYu Deng"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469002138497","@type":"Researcher","foaf:name":[{"@value":"Jia Lu"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469002138498","@type":"Researcher","foaf:name":[{"@value":"Viswanathan Sivakumar"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469002138499","@type":"Researcher","foaf:name":[{"@value":"Eng Ang Ling"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469002138496","@type":"Researcher","foaf:name":[{"@value":"Charanjit Kaur"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10156305"},{"@type":"EISSN","@value":"17503639"}],"prism:publicationName":[{"@value":"Brain Pathology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2008-03-27","prism:volume":"18","prism:number":"3","prism:startingPage":"387","prism:endingPage":"400"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1750-3639.2008.00138.x"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1750-3639.2008.00138.x"}],"createdAt":"2008-03-28","modifiedAt":"2023-09-28","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002218669678592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Brazilian Green Propolis Suppresses the Hypoxia-Induced Neuroinflammatory Responses by Inhibiting NF-<i>κ</i>B Activation in Microglia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285711330543360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nutrients, Microglia Aging, and Brain Aging"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656244502656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neuroprotective effect of water-dispersible hesperetin in retinal ischemia reperfusion injury"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/j.1750-3639.2008.00138.x"},{"@type":"CROSSREF","@value":"10.1155/2013/906726_references_DOI_90PWfCkxRWanu6NmQjewb2Qtpk0"},{"@type":"CROSSREF","@value":"10.1155/2016/7498528_references_DOI_90PWfCkxRWanu6NmQjewb2Qtpk0"},{"@type":"CROSSREF","@value":"10.1007/s10384-015-0415-z_references_DOI_90PWfCkxRWanu6NmQjewb2Qtpk0"}]}