{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361981469074183552.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.hepres.2006.06.001"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S138663460600218X?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S138663460600218X?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"16956789"}}],"dc:title":[{"@value":"Spatial and chronological differences in hepatitis B virus genotypes from patients with acute hepatitis B in Japan"}],"description":[{"notation":[{"@value":"Genotypes of hepatitis B virus (HBV) were determined in 485 patients with acute hepatitis B from all over Japan. They were A in 92 (19%), Ba in 26 (5%), Bj in 32 (7%), C in 330 (68%) and D in 5 (1%). Sexual contacts were the main route of transmission in them. Overall, HBV persisted in only 5 of the 464 (1%) followed patients. Genotypes C accounted for more than 68% in northern as well as southern areas, contrasting with genotype A accounting for 34% in and around the Metropolitan areas. During 24 years from 1982 to 2005, genotype A increased from 5% to 33%, while genotype B gradually decreased from 26% to 8%. Fulminant hepatitis was significantly more frequent in infection with genotype Bj (41%) than those with the other genotypes (p0.01). The core-promoter double mutation (T1762/A1764) and precore stop-codon mutation (A1896) were more frequent in patients with fulminant than acute self-limited hepatitis (57% versus 15% and 58% versus 10%, respectively, p0.01 for both). In conclusion, genotype A distributes unevenly over Japan, prevails in younger patients through sexual transmission and has increased with years. Furthermore, fulminant outcome was more frequent in patients with genotype Bj than those with the other genotypes."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380285706238094604","@type":"Researcher","foaf:name":[{"@value":"F SUGAUCHI"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469074183557","@type":"Researcher","foaf:name":[{"@value":"E ORITO"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469074183552","@type":"Researcher","foaf:name":[{"@value":"T OHNO"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469074183556","@type":"Researcher","foaf:name":[{"@value":"Y TANAKA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469074183681","@type":"Researcher","foaf:name":[{"@value":"A OZASA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469074183680","@type":"Researcher","foaf:name":[{"@value":"J KANG"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469074183682","@type":"Researcher","foaf:name":[{"@value":"J TOYODA"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469074183553","@type":"Researcher","foaf:name":[{"@value":"T KURAMITSU"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469074183558","@type":"Researcher","foaf:name":[{"@value":"K SUZUKI"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469074183554","@type":"Researcher","foaf:name":[{"@value":"E TANAKA"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13866346"}],"prism:publicationName":[{"@value":"Hepatology Research"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2006-10","prism:volume":"36","prism:number":"2","prism:startingPage":"107","prism:endingPage":"114"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S138663460600218X?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S138663460600218X?httpAccept=text/plain"}],"createdAt":"2006-09-08","modifiedAt":"2019-01-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002216004487296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Association between S21 substitution in the core protein of hepatitis B virus and fulminant hepatitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235757163264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Management of hepatitis B: Consensus of the Japan Society of Hepatology 2009"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235779380096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Geographic distribution and characteristics of genotype A hepatitis B virus infection in acute and chronic hepatitis B patients in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706238094848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Virological and Clinical Characteristics of Hepatitis B Virus Genotype A"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710501032064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Novel hepatitis <scp>B</scp> virus strain developing due to recombination between genotypes <scp>H</scp> and <scp>B</scp> strains isolated from a <scp>J</scp>apanese patient"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168116348928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"JSH Guidelines for the Management of Hepatitis B Virus Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848655117702784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Shifting hepatitis B virus genotypes of acute hepatitis B patients in northeast Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848659540475904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Enhanced Replication of Hepatitis B Virus With Frameshift in the Precore Region Found in Fulminant Hepatitis Patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848659861074176","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Enhanced pregenomic RNA levels and lowered precore mRNA transcription efficiency in a genotype A hepatitis B virus genome with C1766T and T1768A mutations obtained from a fulminant hepatitis patient"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848660454528128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Estimating numbers of persons with persistent hepatitis <scp>B</scp> virus infection transmitted vertically and horizontally in the birth cohort during 1950–1985 in <scp>J</scp>apan"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204789950848","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"ＨＩＶ，ＨＢＶ　ｓｕｂｇｅｎｏｔｙｐｅ　Ａｅ重複キャリアに急性発症したＢ型急性肝障害の１例"},{"@language":"en","@value":"A case of acute liver injury presented in a chronic carrier of HBV subgenotype Ae co-infected with human immunodeficiency virus"},{"@value":"症例報告 HIV, HBV subgenotype Ae重複キャリアに急性発症したB型急性肝障害の1例"},{"@language":"ja-Kana","@value":"ショウレイ ホウコク HIV HBV subgenotype Ae チョウフク キャリア ニ キュウセイ ハッショウシタ Bガタ キュウセイ カンショウガイ ノ 1レイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204792912128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Universal hepatitis B vaccination: pros and cons"},{"@language":"ja","@value":"ユニバーサルＨＢワクチネーション：是か非か？"},{"@language":"ja-Kana","@value":"ユニバーサル HB ワクチネーション ゼ カ ヒ カ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204794520320","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Transition and problems of hepatitis B virus genotypes among patients with acute and chronic infection in Japan"},{"@language":"ja","@value":"わが国におけるB型肝炎ウィルス遺伝子型の変遷と問題点"},{"@value":"Editorial わが国におけるB型肝炎ウィルス遺伝子型の変遷と問題点"},{"@language":"ja-Kana","@value":"Editorial ワガクニ ニ オケル Bガタ カンエン ウィルス イデンシガタ ノ ヘンセン ト モンダイテン"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204794901376","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Transmission of genotype A (A2) hepatitis B virus from patients who developed acute hepatitis B to their sexual partners, via interspousal or homosexual infection"},{"@language":"ja","@value":"配偶者間及び同性愛者間で認められたB型急性肝炎例を感染源とするB型肝炎ウイルスA2型株感染"},{"@value":"症例報告 配偶者間及び同性愛者間で認められたB型急性肝炎例を感染源とするB型肝炎ウイルスA2型株感染"},{"@language":"ja-Kana","@value":"ショウレイ ホウコク ハイグウシャ カン オヨビ ドウ セイアイシャ カン デ ミトメラレタ Bガタ キュウセイ カンエンレイ オ カンセン ゲン ト スル Bガタ カンエンウイルス A2ガタカブ カンセン"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204794990208","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A case of hepatocellular carcinoma arising from chronic hepatitis B caused by HBV genotype Ae and NASH without perisinusoidal fibrosis"},{"@language":"ja","@value":"肝細胞癌を合併した非線維化NASH及び遺伝子型Ae HBV起因B型慢性肝炎の1例"},{"@value":"症例報告 肝細胞癌を合併した非線維化NASH及び遺伝子型AeHBV起因B型慢性肝炎の1例"},{"@language":"ja-Kana","@value":"ショウレイ ホウコク キモ サイボウガン オ ガッペイ シタ ヒセンイカ NASH オヨビ イデンシガタ AeHBV キイン Bガタ マンセイ カンエン ノ 1レイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204795693056","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Distribution of hepatitis B viral genotypes in Japan"},{"@language":"ja","@value":"わが国におけるB型肝炎ウイルス遺伝子型の分布"},{"@value":"Editorial わが国におけるB型肝炎ウイルス遺伝子型の分布"},{"@language":"ja-Kana","@value":"Editorial ワガクニ ニ オケル Bガタ カンエン ウイルス イデンシガタ ノ ブンプ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204870288512","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"An Adult Patient with Acute Infection with Hepatitis B Virus Genotype C that Progressed to Chronic Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205078952960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Reverse Genetics of Hepatitis B virus"},{"@language":"ja","@value":"B型肝炎ウイルス （HBV）のリバースジェネティックス"},{"@language":"ja-Kana","@value":"Bガタ カンエンウイルス(HBV)ノ リバースジェネティックス"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679765858688","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Recent trends in acute hepatitis B in Japan"},{"@language":"ja","@value":"我国に於ける急性B型肝炎の最近の動向"},{"@value":"Editorial 我国に於ける急性B型肝炎の最近の動向"},{"@language":"ja-Kana","@value":"Editorial ワガクニ ニ オケル キュウセイ Bガタ カンエン ノ サイキン ノ ドウコウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679766844160","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"国内初となる，ＨＢＶ　ｇｅｎｏｔｙｐｅ　ＨによるＢ型急性肝炎の１例"},{"@language":"en","@value":"First domestic case of acute hepatitis caused by an HBV genotype H strain"},{"@language":"ja-Kana","@value":"コクナイハツ ト ナル HBV genotype H ニ ヨル Bガタ キュウセイ カンエン ノ 1レイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679771619840","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Two cases of acute hepatitis due to hepatitis E virus that are indigenous to Kitakyushu: a case report"},{"@language":"ja","@value":"北九州に土着したE型肝炎ウイルス株による急性肝炎の2例"},{"@value":"B型肝炎治療ガイドライン(第1.1版)"},{"@language":"ja-Kana","@value":"Bガタ カンエン チリョウ ガイドライン(ダイ1.1ハン)"},{"@language":"ja-Kana","@value":"キタキュウシュウ ニ ドチャク シタ Eガタ カンエンウイルスカブ ニ ヨル キュウセイ カンエン ノ 2レイ"},{"@value":"Guidelines for the management of hepatitis B virus infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679772012160","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A fatal case of acute liver failure with hepatitis B virus genotype D infection"},{"@language":"ja","@value":"B型肝炎ウイルスgenotype D感染または再活性化を契機に急性肝不全で死亡した1例"},{"@value":"症例報告 B型肝炎ウイルスgenotype D感染または再活性化を契機に急性肝不全で死亡した1例"},{"@language":"ja-Kana","@value":"ショウレイ ホウコク Bガタ カンエンウイルス genotype D カンセン マタハ サイカッセイカ オ ケイキ ニ キュウセイ カンフゼン デ シボウ シタ 1レイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679772125184","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Gianotti-Crosti syndrome associated with hepatitis B virus (HBV) infection in an adult: a case report"},{"@language":"ja","@value":"成人発症のＢ型肝炎ウイルスに関連したＧｉａｎｏｔｔｉ－Ｃｒｏｓｔｉ症候群の１例"},{"@value":"症例報告 成人発症のB型肝炎ウイルスに関連したGianotti-Crosti症候群の1例"},{"@language":"ja-Kana","@value":"ショウレイ ホウコク セイジン ハッショウ ノ Bガタ カンエン ウイルス ニ カンレン シタ Gianotti Crosti ショウコウグン ノ 1レイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679847274240","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"An HBV-HIV Co-infected Patient Treated with Tenofovir-based Therapy who Achieved HBs Antigen/Antibody Seroconversion"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681421299712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"6. Hepatitis Virus"},{"@language":"ja","@value":"6．肝炎ウイルス"},{"@value":"肝炎ウイルス"},{"@language":"ja-Kana","@value":"カンエン ウイルス"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282763017345152","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"日本肝臓学会評議員を対象としたB型肝炎ワクチンに関するアンケート調査"},{"@language":"ja-Kana","@value":"ニホン カンゾウ ガッカイ ヒョウギイン オ タイショウ ト シタ Bガタ カンエン ワクチン ニ カンスル アンケート チョウサ"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.hepres.2006.06.001"},{"@type":"OPENAIRE","@value":"doi_dedup___::34e731c61702090b31fa3097041b9224"},{"@type":"CROSSREF","@value":"10.1111/j.1872-034x.2010.00739.x_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.1111/jgh.13030_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.2957/kanzo.51.615_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.2957/kanzo.53.90_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.2169/internalmedicine.51.6142_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.1007/s00535-017-1367-5_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.1111/hepr.12238_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.2957/kanzo.50.269_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.1111/hepr.12269_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.2957/kanzo.49.549_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.2957/kanzo.54.373_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.2169/naika.97.2704_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.1002/jmv.24309_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.1093/infdis/jir485_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.1099/jgv.0.000566_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.1111/hepr.12288_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.2957/kanzo.48.109_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.2957/kanzo.50.598_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.2957/kanzo.54.748_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.2957/kanzo.54.402_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.2957/kanzo.47.419_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.2957/kanzo.48.57_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.2169/internalmedicine.53.2131_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.2222/jsv.63.23_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.1016/j.jcv.2012.06.011_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"},{"@type":"CROSSREF","@value":"10.2957/kanzo.59.259_references_DOI_ToPldadPJY06qUZMa8j9go9xuqj"}]}