{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361981469093232256.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1101/gad.1431006"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1101/gad.1431006"}}],"dc:title":[{"@value":"BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p><jats:italic>BRCA1</jats:italic> (<jats:italic>Breast Cancer Susceptibility Gene 1</jats:italic>) possesses an N-terminal Ring domain and tandem C-terminal BRCT motifs. While the Ring domain has E3 ubiquitin ligase activity, the BRCA1 BRCT domains specifically recognize phospho-serine motifs. Here, we demonstrate that BRCA1 Ring domain catalyzes CtIP ubiquitination in a manner that depends on a phosphorylation-mediated interaction between CtIP and BRCA1 BRCT domains. The BRCA1-dependent ubiquitination of CtIP does not target CtIP for degradation. Instead, ubiquitinated CtIP associates with chromatin following DNA damage and participates in G2/M checkpoint control. Thus, we propose that BRCA1 can regulate the functions of its substrates through nonproteasomal pathways that do not involve substrate degradation.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381981469093232259","@type":"Researcher","foaf:name":[{"@value":"Xiaochun Yu"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469093232257","@type":"Researcher","foaf:name":[{"@value":"Shuang Fu"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469093232260","@type":"Researcher","foaf:name":[{"@value":"Maoyi Lai"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469093232258","@type":"Researcher","foaf:name":[{"@value":"Richard Baer"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469093232256","@type":"Researcher","foaf:name":[{"@value":"Junjie Chen"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"08909369"},{"@type":"EISSN","@value":"15495477"}],"prism:publicationName":[{"@value":"Genes & Development"}],"dc:publisher":[{"@value":"Cold Spring Harbor Laboratory"}],"prism:publicationDate":"2006-07-01","prism:volume":"20","prism:number":"13","prism:startingPage":"1721","prism:endingPage":"1726"},"reviewed":"false","url":[{"@id":"https://syndication.highwire.org/content/doi/10.1101/gad.1431006"}],"createdAt":"2006-07-05","modifiedAt":"2021-11-16","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050282810768198272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"FANCD2 Binds CtIP and Regulates DNA-End Resection during DNA Interstrand Crosslink Repair"}]},{"@id":"https://cir.nii.ac.jp/crid/1050845760743566720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous 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