{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361981469199248256.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1073/pnas.2014441117"}},{"identifier":{"@type":"URI","@value":"http://www.pnas.org/syndication/doi/10.1073/pnas.2014441117"}},{"identifier":{"@type":"URI","@value":"https://pnas.org/doi/pdf/10.1073/pnas.2014441117"}}],"dc:title":[{"@value":"Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine lacks activity"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Significance</jats:title><jats:p>The previous lack of consensus around the use of hydroxychloroquine for COVID-19 patients underlines the need to thoroughly assess the in vivo efficacy of drugs against SARS-CoV-2. Small animal infection models, such as the hamster model, have a pivotal place herein. We here show in vivo preclinical results with favipiravir which indicate that antiviral efficacy against SARS-CoV-2 might only be achieved with a very high dose. Hydroxychloroquine, on the other hand, completely lacks antiviral activity, thus providing no scientific basis for its further use in COVID-19 patients. With this study on two key antiviral candidates, we establish the baseline for SARS-CoV-2 antiviral treatment, which will allow us to identify superior antiviral candidates in the near future.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381981469199248386","@type":"Researcher","foaf:name":[{"@value":"Suzanne J. F. Kaptein"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium;"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469199248387","@type":"Researcher","foaf:name":[{"@value":"Sofie Jacobs"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium;"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469199248263","@type":"Researcher","foaf:name":[{"@value":"Lana Langendries"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium;"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469199248259","@type":"Researcher","foaf:name":[{"@value":"Laura Seldeslachts"}],"jpcoar:affiliationName":[{"@value":"Biomedical MRI and Molecular Small Animal Imaging Centre, Department of Imaging and Pathology, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium;"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469199248392","@type":"Researcher","foaf:name":[{"@value":"Sebastiaan ter Horst"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium;"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469199248397","@type":"Researcher","foaf:name":[{"@value":"Laurens Liesenborghs"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke 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Katholieke Universiteit Leuven, B-3000 Leuven, Belgium;"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469199248389","@type":"Researcher","foaf:name":[{"@value":"Karine Barthelemy"}],"jpcoar:affiliationName":[{"@value":"Unité des Virus Emergents, Aix Marseille University, Institut de Recherche pour le Développement (IRD) 190, Institut National de la Santé et de la Recherche Médicale (INSERM) 1207, 13005 Marseille, France;"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469199248388","@type":"Researcher","foaf:name":[{"@value":"Elke Maas"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium;"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469199248257","@type":"Researcher","foaf:name":[{"@value":"Carolien De Keyzer"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Virology and Chemotherapy, Department of 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