{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361981469297986304.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1242/dev.122.4.1165"}},{"identifier":{"@type":"URI","@value":"https://journals.biologists.com/dev/article-pdf/122/4/1165/3069134/develop_122_4_1165.pdf"}}],"dc:title":[{"@value":"Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>ABSTRACT</jats:title>\n               <jats:p>A key event in the development of the mammalian cerebral cortex is the generation of neuronal populations during embryonic life. Previous studies have revealed many details of cortical neuron development including cell birthdates, migration patterns and lineage relationships. Programmed cell death is a potentially important mechanism that could alter the numbers and types of developing cortical cells during these early embryonic phases. While programmed cell death has been documented in other parts of the embryonic central nervous system, its operation has not been previously reported in the embryonic cortex because of the lack of cell death markers and the difficulty in following the entire population of cortical cells. Here, we have investigated the spatial and temporal distribution of dying cells in the embryonic cortex using an in situ end- labelling technique called ‘ISEL+’ that identifies fragmented nuclear DNA in dying cells with increased sensitivity. The period encompassing murine cerebral cortical neurogenesis was examined, from embryonic days 10 through 18. Dying cells were rare at embryonic day 10, but by embryonic day 14, 70% of cortical cells were found to be dying. This number declined to 50% by embryonic day 18, and few dying cells were observed in the adult cerebral cortex. Surprisingly, while dying cells were observed throughout the cerebral cortical wall, the majority were found within zones of cell proliferation rather than in regions of postmitotic neurons. These observations suggest that multiple mechanisms may regulate programmed cell death in the developing cortex. Moreover, embryonic cell death could be an important factor enabling the selection of appropriate cortical cells before they complete their differentiation in postnatal life.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380579817457085696","@type":"Researcher","foaf:name":[{"@value":"Anne J. Blaschke"}],"jpcoar:affiliationName":[{"@value":"University of California 1 Biology Graduate Program, The Department of Pharmacology, School of Medicine , , San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0636, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380579817457085698","@type":"Researcher","foaf:name":[{"@value":"Kristina Staley"}],"jpcoar:affiliationName":[{"@value":"University of California 1 Biology Graduate Program, The Department of Pharmacology, School of Medicine , , San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0636, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380579817457085697","@type":"Researcher","foaf:name":[{"@value":"Jerold Chun"}],"jpcoar:affiliationName":[{"@value":"University of California 2 Neurosciences and Biomedical Sciences Graduate Program, The Department of Pharmacology, School of Medicine , , San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0636, USA"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09501991"},{"@type":"EISSN","@value":"14779129"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/09501991"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/09501991"}],"prism:publicationName":[{"@value":"Development"}],"dc:publisher":[{"@value":"The Company of Biologists"}],"prism:publicationDate":"1996-04-01","prism:volume":"122","prism:number":"4","prism:startingPage":"1165","prism:endingPage":"1174"},"reviewed":"false","dc:rights":["http://www.biologists.com/user-licence-1-1/"],"url":[{"@id":"https://journals.biologists.com/dev/article-pdf/122/4/1165/3069134/develop_122_4_1165.pdf"}],"createdAt":"2021-04-26","modifiedAt":"2025-02-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004231413572480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Apoptotic and Non-apoptotic Caspase Functions in Neural Development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298757182057088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Expression and distribution of generated neurons and endogenous precursors in rat cerebral cortical venous ischemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165728949632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Programmed Cell Death and Caspase Functions During Neural Development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567184506642688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Laminar and Areal Expression of Unc5d and Its Role in Cortical Cell Survival"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206409640064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Molecular Genetic Control of Caspases and JNK-mediated Neural Cell Death."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679673200384","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Role of Apaf-1 in Programmed Cell Death: From Worm to Tumor."},{"@language":"ja-Kana","@value":"Role of Apaf 1 in Programmed Cell Death From Worm to Tumor"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679879278976","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mechanisms of neurotoxicity induced in the developing brain of mice and rats by DNA-damaging chemicals"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1242/dev.122.4.1165"},{"@type":"CROSSREF","@value":"10.1007/s11064-010-0341-x_references_DOI_FdUU5SBHEiLK6kNW2RGzT4Lih0U"},{"@type":"CROSSREF","@value":"10.1016/j.ibneur.2022.12.005_references_DOI_FdUU5SBHEiLK6kNW2RGzT4Lih0U"},{"@type":"CROSSREF","@value":"10.1679/aohc.65.291_references_DOI_FdUU5SBHEiLK6kNW2RGzT4Lih0U"},{"@type":"CROSSREF","@value":"10.1093/cercor/bhq265_references_DOI_FdUU5SBHEiLK6kNW2RGzT4Lih0U"},{"@type":"CROSSREF","@value":"10.2131/jts.36.695_references_DOI_FdUU5SBHEiLK6kNW2RGzT4Lih0U"},{"@type":"CROSSREF","@value":"10.1016/bs.ctdb.2015.07.016_references_DOI_FdUU5SBHEiLK6kNW2RGzT4Lih0U"},{"@type":"CROSSREF","@value":"10.1247/csf.28.3_references_DOI_FdUU5SBHEiLK6kNW2RGzT4Lih0U"}]}