Targeting DNA Double-Strand Breaks with TAL Effector Nucleases

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  • Michelle Christian
    Department of Genetics , Cell Biology and Development and Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota 55455 and
  • Tomas Cermak
    Department of Genetics , Cell Biology and Development and Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota 55455 and
  • Erin L Doyle
    Department of Plant Pathology, Iowa State University, Ames , Iowa 50011
  • Clarice Schmidt
    Department of Plant Pathology, Iowa State University, Ames , Iowa 50011
  • Feng Zhang
    Department of Genetics , Cell Biology and Development and Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota 55455 and
  • Aaron Hummel
    Department of Plant Pathology, Iowa State University, Ames , Iowa 50011
  • Adam J Bogdanove
    Department of Plant Pathology, Iowa State University, Ames , Iowa 50011
  • Daniel F Voytas
    Department of Genetics , Cell Biology and Development and Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota 55455 and

説明

<jats:title>Abstract</jats:title> <jats:p>Engineered nucleases that cleave specific DNA sequences in vivo are valuable reagents for targeted mutagenesis. Here we report a new class of sequence-specific nucleases created by fusing transcription activator-like effectors (TALEs) to the catalytic domain of the FokI endonuclease. Both native and custom TALE-nuclease fusions direct DNA double-strand breaks to specific, targeted sites.</jats:p>

収録刊行物

  • Genetics

    Genetics 186 (2), 757-761, 2010-10-01

    Oxford University Press (OUP)

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