{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361981469987006848.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.ijheh.2013.03.010"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1438463913000485?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1438463913000485?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"23608001"}}],"dc:title":[{"@value":"Dietary cadmium intake and breast cancer risk in Japanese women: A case–control study"}],"description":[{"notation":[{"@value":"Cadmium, an environmental pollutant, may act like an estrogen and be a potential risk factor for estrogen-dependent diseases such as breast cancer. We examined the hypothesis that higher dietary cadmium intake is associated with risk of overall and hormone receptor-defined breast cancer in Japanese women, a population with a relatively high cadmium intake. The study was conducted under a case-control design in 405 eligible matched pairs from May 2001 to September 2005 at four hospitals in Nagano Prefecture, Japan. Dietary cadmium intake was estimated using a food frequency questionnaire. Multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of breast cancer and its hormone-receptor-defined subtypes were calculated by tertile of dietary cadmium intake. We found no significant association between dietary cadmium and risk of total breast cancer in either crude or multivariable-adjusted analysis. Adjusted ORs for tertiles of cadmium intake were 1.00, 1.19, and 1.23 (95% CI, 0.76-2.00; P for trend=0.39) for whole breast cancer. Further, no significant associations were seen across strata of menopausal status, smoking, and diabetes in multivariable-adjusted models except for adjusted OR for continuous cadmium intake in postmenopausal women. A statistically significant association was found for estrogen receptor-positive (ER+) tumors among postmenopausal women (adjusted OR=1.00, 1.16, and 1.94 [95% CI, 1.04-3.63; P for trend=0.032]). Although the present study found no overall association between dietary cadmium intake and breast cancer risk, higher cadmium intake was associated with increased risk of ER+ breast cancer in postmenopausal women, at least at regular intake levels in Japanese women in the general population. Further studies are needed to confirm this association."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381981469987006723","@type":"Researcher","foaf:name":[{"@value":"Hiroaki Itoh"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469987006720","@type":"Researcher","foaf:name":[{"@value":"Motoki Iwasaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469987006721","@type":"Researcher","foaf:name":[{"@value":"Norie Sawada"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469987006728","@type":"Researcher","foaf:name":[{"@value":"Ribeka Takachi"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469987006725","@type":"Researcher","foaf:name":[{"@value":"Yoshio Kasuga"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469987006724","@type":"Researcher","foaf:name":[{"@value":"Shiro Yokoyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469987006730","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Onuma"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469987006722","@type":"Researcher","foaf:name":[{"@value":"Hideki Nishimura"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469987006729","@type":"Researcher","foaf:name":[{"@value":"Ritsu Kusama"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469987006726","@type":"Researcher","foaf:name":[{"@value":"Kazuhito Yokoyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981469987006727","@type":"Researcher","foaf:name":[{"@value":"Shoichiro Tsugane"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"14384639"}],"prism:publicationName":[{"@value":"International Journal of Hygiene and Environmental Health"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2014-01","prism:volume":"217","prism:number":"1","prism:startingPage":"70","prism:endingPage":"77"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S1438463913000485?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S1438463913000485?httpAccept=text/plain"}],"createdAt":"2013-03-30","modifiedAt":"2025-10-25","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Risk","dc:title":"Risk"},{"@id":"https://cir.nii.ac.jp/all?q=Breast%20Neoplasms","dc:title":"Breast Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Food%20Contamination","dc:title":"Food Contamination"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Diet","dc:title":"Diet"},{"@id":"https://cir.nii.ac.jp/all?q=Japan","dc:title":"Japan"},{"@id":"https://cir.nii.ac.jp/all?q=Case-Control%20Studies","dc:title":"Case-Control Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Odds%20Ratio","dc:title":"Odds Ratio"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Environmental%20Pollutants","dc:title":"Environmental Pollutants"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Cadmium","dc:title":"Cadmium"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360013168732036608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Using profitable chrysanthemums for phytoremediation of Cd- and Zn-contaminated soils in the suburb of 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