{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361981470111675264.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1158/2159-8290.cd-18-0432"}},{"identifier":{"@type":"URI","@value":"https://aacrjournals.org/cancerdiscovery/article-pdf/8/10/1286/1845388/1286.pdf"}}],"dc:title":[{"@value":"A Digital RNA Signature of Circulating Tumor Cells Predicting Early Therapeutic Response in Localized and Metastatic Breast Cancer"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>The multiplicity of new therapies for breast cancer presents a challenge for treatment selection. We describe a 17-gene digital signature of breast circulating tumor cell (CTC)–derived transcripts enriched from blood, enabling high-sensitivity early monitoring of response. In a prospective cohort of localized breast cancer, an elevated CTC score after three cycles of neoadjuvant therapy is associated with residual disease at surgery (P = 0.047). In a second prospective cohort with metastatic breast cancer, baseline CTC score correlates with overall survival (P = 0.02), as does persistent CTC signal after 4 weeks of treatment (P = 0.01). In the subset with estrogen receptor (ER)–positive disease, failure to suppress ER signaling within CTCs after 3 weeks of endocrine therapy predicts early progression (P = 0.008). Drug-refractory ER signaling within CTCs overlaps partially with presence of ESR1 mutations, pointing to diverse mechanisms of acquired endocrine drug resistance. Thus, CTC-derived digital RNA signatures enable noninvasive pharmacodynamic measurements to inform therapy in breast cancer.</jats:p>\n                  <jats:p>Significance: Digital analysis of RNA from CTCs interrogates treatment responses of both localized and metastatic breast cancer. Quantifying CTC-derived ER signaling during treatment identifies patients failing to respond to ER suppression despite having functional ESR1. Thus, noninvasive scoring of CTC-RNA signatures may help guide therapeutic choices in localized and advanced breast cancer. Cancer Discov; 8(10); 1286–99. ©2018 AACR.</jats:p>\n                  <jats:p>This article is highlighted in the In This Issue feature, p. 1195</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381981470111675274","@type":"Researcher","foaf:name":[{"@value":"Tanya T. Kwan"}],"jpcoar:affiliationName":[{"@value":"1Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470111675138","@type":"Researcher","foaf:name":[{"@value":"Aditya Bardia"}],"jpcoar:affiliationName":[{"@value":"1Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts."},{"@value":"2Division of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470111675272","@type":"Researcher","foaf:name":[{"@value":"Laura M. Spring"}],"jpcoar:affiliationName":[{"@value":"1Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts."},{"@value":"2Division of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470111675270","@type":"Researcher","foaf:name":[{"@value":"Anita Giobbie-Hurder"}],"jpcoar:affiliationName":[{"@value":"3Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470111675266","@type":"Researcher","foaf:name":[{"@value":"Mark Kalinich"}],"jpcoar:affiliationName":[{"@value":"1Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470111675276","@type":"Researcher","foaf:name":[{"@value":"Taronish Dubash"}],"jpcoar:affiliationName":[{"@value":"1Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470111675275","@type":"Researcher","foaf:name":[{"@value":"Tilak Sundaresan"}],"jpcoar:affiliationName":[{"@value":"1Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470111675137","@type":"Researcher","foaf:name":[{"@value":"Xin Hong"}],"jpcoar:affiliationName":[{"@value":"1Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470111675277","@type":"Researcher","foaf:name":[{"@value":"Joseph A. LiCausi"}],"jpcoar:affiliationName":[{"@value":"1Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470111675268","@type":"Researcher","foaf:name":[{"@value":"Uyen Ho"}],"jpcoar:affiliationName":[{"@value":"1Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470111675264","@type":"Researcher","foaf:name":[{"@value":"Erin J. Silva"}],"jpcoar:affiliationName":[{"@value":"1Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470111675267","@type":"Researcher","foaf:name":[{"@value":"Ben S. Wittner"}],"jpcoar:affiliationName":[{"@value":"1Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470111675271","@type":"Researcher","foaf:name":[{"@value":"Lecia V. Sequist"}],"jpcoar:affiliationName":[{"@value":"1Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts."},{"@value":"2Division of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470111675269","@type":"Researcher","foaf:name":[{"@value":"Ravi Kapur"}],"jpcoar:affiliationName":[{"@value":"4Center for Bioengineering in Medicine, Massachusetts General Hospital and Harvard Medical School, and Shriners Hospital for Children, Boston, Massachusetts."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470111675136","@type":"Researcher","foaf:name":[{"@value":"David T. Miyamoto"}],"jpcoar:affiliationName":[{"@value":"1Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts."},{"@value":"5Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470111675278","@type":"Researcher","foaf:name":[{"@value":"Mehmet Toner"}],"jpcoar:affiliationName":[{"@value":"4Center for Bioengineering in Medicine, Massachusetts General Hospital and Harvard Medical School, and Shriners Hospital for Children, Boston, Massachusetts."},{"@value":"6Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470111675273","@type":"Researcher","foaf:name":[{"@value":"Daniel A. Haber"}],"jpcoar:affiliationName":[{"@value":"1Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts."},{"@value":"2Division of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts."},{"@value":"7Howard Hughes Medical Institute, Chevy Chase, Maryland."}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470111675265","@type":"Researcher","foaf:name":[{"@value":"Shyamala Maheswaran"}],"jpcoar:affiliationName":[{"@value":"1Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts."},{"@value":"6Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"21598274"},{"@type":"EISSN","@value":"21598290"}],"prism:publicationName":[{"@value":"Cancer Discovery"}],"dc:publisher":[{"@value":"American Association for Cancer Research (AACR)"}],"prism:publicationDate":"2018-10-01","prism:volume":"8","prism:number":"10","prism:startingPage":"1286","prism:endingPage":"1299"},"reviewed":"false","url":[{"@id":"https://aacrjournals.org/cancerdiscovery/article-pdf/8/10/1286/1845388/1286.pdf"}],"createdAt":"2018-08-13","modifiedAt":"2022-06-06","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360009142521356032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Distribution of Residual Disease and Recurrence Patterns in Pathological Responders After Neoadjuvant Chemotherapy for Esophageal Squamous Cell Carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617672131968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mesenchymal Characteristics and Predictive Biomarkers on Circulating Tumor Cells for Therapeutic Strategy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306905628806400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Serial Changes of Circulating Tumor Cells in Patients with Hepatocellular Carcinoma Treated with Atezolizumab Plus Bevacizumab"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1158/2159-8290.cd-18-0432"},{"@type":"CROSSREF","@value":"10.3390/cancers12123588_references_DOI_Aot4wqfcCpDMQXD0DTVVeTUnn4M"},{"@type":"CROSSREF","@value":"10.1097/sla.0000000000004436_references_DOI_Aot4wqfcCpDMQXD0DTVVeTUnn4M"},{"@type":"CROSSREF","@value":"10.3390/cancers16132410_references_DOI_Aot4wqfcCpDMQXD0DTVVeTUnn4M"}]}