{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361981470394339072.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/1523-1747.ep12470233"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0022202X91904608?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0022202X91904608?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"2007790"}},{"identifier":{"@type":"NAID","@value":"30014535072"}}],"dc:title":[{"@value":"Decreased Level of Ceramides in Stratum Corneum of Atopic Dermatitis: An Etiologic Factor in Atopic Dry Skin?"}],"description":[{"notation":[{"@value":"Stratum corneum lipids are an important determinant for both water-retention function and permeability-barrier function in the stratum corneum. However, their major constituent, ceramides, have not been analyzed in detail in skin diseases such as atopic dermatitis that show defective water-retention and permeability-barrier function. In an attempt to assess the quantity of ceramides per unit mass of the stratum corneum in atopic dermatitis, stratum corneum sheet was removed from the forearm skin by stripping with cyanoacrylate resin and placed in hexane/ethanol extraction to yield stratum corneum lipids. The stratum corneum was dispersed by solubilization of cyanoacrylate resin with dimethylformamide, and after membrane filtration, the weight of the stratum corneum mass was measured. The ceramides were quantified by thin-layer chromatography and evaluated as microgram/mg stratum corneum. In the forearm skin of healthy individuals (n = 65), the total ceramide content significantly declined with increasing age. In atopic dermatitis (n = 32-35), there was a marked reduction in the amount of ceramides in the lesional forearm skin compared with those of healthy individuals of the same age. Interestingly, the non-lesional skin also exhibited a similar and significant decrease of ceramides. Among six ceramide fractions, ceramide 1 was most significantly reduced in both lesional and non-lesional skin. These findings suggest that an insufficiency of ceramides in the stratum corneum is an etiologic factor in atopic dry skin."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381981470394339073","@type":"Researcher","foaf:name":[{"@value":"Genji Imokawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470394339074","@type":"Researcher","foaf:name":[{"@value":"Akihito Abe"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470394339072","@type":"Researcher","foaf:name":[{"@value":"Kumi Jin"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470394339076","@type":"Researcher","foaf:name":[{"@value":"Yuko Higaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470394339075","@type":"Researcher","foaf:name":[{"@value":"Makoto Kawashima"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470394339077","@type":"Researcher","foaf:name":[{"@value":"Akira Hidano"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0022202X"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/0022202X"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/0022202X"}],"prism:publicationName":[{"@value":"Journal of Investigative Dermatology"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"1991-04","prism:volume":"96","prism:number":"4","prism:startingPage":"523","prism:endingPage":"526"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/open-access/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0022202X91904608?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0022202X91904608?httpAccept=text/plain"}],"createdAt":"2004-07-15","modifiedAt":"2024-01-13","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Aged,%2080%20and%20over","dc:title":"Aged, 80 and over"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Aging","dc:title":"Aging"},{"@id":"https://cir.nii.ac.jp/all?q=Adolescent","dc:title":"Adolescent"},{"@id":"https://cir.nii.ac.jp/all?q=Infant","dc:title":"Infant"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Biology","dc:title":"Cell Biology"},{"@id":"https://cir.nii.ac.jp/all?q=Dermatology","dc:title":"Dermatology"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Ceramides","dc:title":"Ceramides"},{"@id":"https://cir.nii.ac.jp/all?q=Biochemistry","dc:title":"Biochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Dermatitis,%20Atopic","dc:title":"Dermatitis, Atopic"},{"@id":"https://cir.nii.ac.jp/all?q=Child,%20Preschool","dc:title":"Child, Preschool"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Chromatography,%20Thin%20Layer","dc:title":"Chromatography, Thin Layer"},{"@id":"https://cir.nii.ac.jp/all?q=Child","dc:title":"Child"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Biology","dc:title":"Molecular Biology"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Skin","dc:title":"Skin"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050007072217855744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"アトピー性皮膚炎の病態と治療"}]},{"@id":"https://cir.nii.ac.jp/crid/1050306506455311744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Essential role of the cytochrome P450 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Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204297819264","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"アトピー性皮膚炎における皮膚バリア機能障害―アレルギー性炎症との相互作用について―"},{"@language":"en","@value":"Barrier Dysfunction in Atopic Dermatitis:"},{"@language":"ja-Kana","@value":"アトピーセイ ヒフエン ニ オケル ヒフ バリア キノウ ショウガイ アレルギーセイ エンショウ トノ ソウゴ サヨウ ニ ツイテ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204297908608","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The examination of the usefulness for atopic dermatitis patient of Eucalyptus extract mixture bathing medicine."},{"@language":"ja","@value":"ユーカリエキス配合入浴剤のアトピー性皮膚炎患者に対する有用性の検討"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204299023488","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"角層と皮膚疾患　前編　　角層のバリア機能を中心として"},{"@language":"en","@value":"Stratum Corneum and Skin Diseases (the former part)"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204299097344","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"皮膚保護成分含有薬用ハンドソープ（花王ソフティ薬用ハンドウオッシュ１０）の抗菌効果と皮膚刺激性の検討"},{"@language":"en","@value":"The Evaluation of New Medical Hand Soap Solution (Kao Softy Medical Handwash 10<SUP>®</SUP>) with Bactericidal Effect and Use Test"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204299152384","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Use results of \"Shokubutsu Monogatari medicated body soap\" and \"Shokubutsu Monogatari medicated soap\" on skin stimulus and dry type delmatosis patients\"."},{"@language":"ja","@value":"「植物物語薬用ボディソープ」，「植物物語薬用石鹸」の皮膚刺激性および乾燥性皮膚疾患患者に対する使用成績"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204299241600","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Significance of Barrier Repair in Non-lesional Dry Skin of Atopic Dermatitis-Efficacy of a Topically Applied Ceramide Cream-"},{"@language":"ja","@value":"アトピックドライスキンにおけるバリアー障害の回復の意義―バリアークリームの塗布と無塗布との比較解析―"},{"@value":"治療 アトピックドライスキンにおけるバリアー障害の回復の意義--バリアークリームの塗布と無塗布との比較解析"},{"@language":"ja-Kana","@value":"チリョウ アトピックドライスキン ニ オケル バリアー ショウガイ ノ カイフク ノ イギ バリアー クリーム ノ トフ ト ムトフ ト ノ ヒカク カイセキ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204299361920","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Psoriasis Patients Have Abnormal Ceramide Profile in Stratum Corneum"},{"@language":"ja","@value":"乾癬角層におけるセラミドの異常"},{"@language":"ja-Kana","@value":"カンセンカクソウ ニ オケル セラミド ノ イジョウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204299981312","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"In atopic dermatitis patients, immunoglobulin A secretion to a body surface 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