{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1361981470462321920.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1160/th07-03-0212"}},{"identifier":{"@type":"URI","@value":"http://www.thieme-connect.de/products/ejournals/pdf/10.1160/TH07-03-0212.pdf"}}],"dc:title":[{"@value":"Venous thromboembolism (VTE) in Europe"}],"dcterms:alternative":[{"@value":"The number of VTE events and associated morbidity and mortality"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Summary</jats:title><jats:p>Venous thromboembolism (VTE) is often asymptomatic, misdiagnosed, and unrecognized at death, and there is a lack of routine postmortem examinations. These factors are thought to result in marked underestimates ofVTE incidence. The objective of our study was to estimate the total burden of VTE within the European Union (EU) per annum. An epidemiological model was constructed to estimate the number of community- and hospital-acquired incidents and recurrent cases (attack rate) of nonfatal VTE and VTE-related deaths, as well as incident and prevalent cases of post-thrombotic syndrome (PTS) and chronic thromboembolic pulmonary hypertension (PH) occurring in the EU per annum. Individual models were developed for six EU countries. The models were populated with data from published literature and, where necessary, expert opinions. The findings were tested using probabilistic sensitivity analyses. The esti mated total number of symptomaticVTE events (range based on probabilistic sensitivity analysis) per annum within the six EU countries was 465,715 (404,664–538,189) cases of deep-vein thrombosis, 295,982 (242,450–360,363) cases of pulmonary embolism (PE), and 370,012 (300,193–483,108) VTE-related deaths. Of these deaths, an estimated 27,473 (7%) were diagnosed as being antemortem; 126,145 (34%) were sudden fatal PE, and 217,394 (59%) followed undiagnosed PE. Almost threequarters of all VTE-related deaths were from hospital-acquired VTE.VTE is a major health problem in the EU, with over one million VTE events or deaths per annum in the six countries examined. Given the availability of effective VTE prophylaxis, many of these events and deaths could have been prevented. These results have important implications for the allocation of healthcare resources.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1381981470462322050","@type":"Researcher","foaf:name":[{"@value":"Giancarlo Agnelli"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470462321921","@type":"Researcher","foaf:name":[{"@value":"Frederick Anderson"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470462322048","@type":"Researcher","foaf:name":[{"@value":"Juan Arcelus"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470462321924","@type":"Researcher","foaf:name":[{"@value":"David Bergqvist"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470462321925","@type":"Researcher","foaf:name":[{"@value":"Josef Brecht"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470462321928","@type":"Researcher","foaf:name":[{"@value":"Ian Greer"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470462321926","@type":"Researcher","foaf:name":[{"@value":"John Heit"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470462321923","@type":"Researcher","foaf:name":[{"@value":"Julia Hutchinson"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470462321930","@type":"Researcher","foaf:name":[{"@value":"Ajay Kakkar"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470462322049","@type":"Researcher","foaf:name":[{"@value":"Dominique Mottier"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470462321927","@type":"Researcher","foaf:name":[{"@value":"Emmanuel Oger"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470462321929","@type":"Researcher","foaf:name":[{"@value":"Meyer-Michel Samama"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470462321922","@type":"Researcher","foaf:name":[{"@value":"Michael Spannagl"}]},{"@id":"https://cir.nii.ac.jp/crid/1381981470462321920","@type":"Researcher","foaf:name":[{"@value":"Alexander Cohen"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03406245"},{"@type":"EISSN","@value":"2567689X"}],"prism:publicationName":[{"@value":"Thrombosis and Haemostasis"}],"dc:publisher":[{"@value":"Georg Thieme Verlag KG"}],"prism:publicationDate":"2007","prism:volume":"98","prism:number":"10","prism:startingPage":"756","prism:endingPage":"764"},"reviewed":"false","url":[{"@id":"http://www.thieme-connect.de/products/ejournals/pdf/10.1160/TH07-03-0212.pdf"}],"createdAt":"2007-10-16","modifiedAt":"2018-03-20","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004236735962112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Validation of simplified PESI score for identification of low-risk patients with pulmonary embolism: From the COMMAND VTE Registry"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004236831604736","@type":"Article","resourceType":"学術雑誌論文(journal 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